ABSTRACT
Introduction: Transcranial direct current stimulation (tDCS) has emerged as a therapeutic option to mitigate symptoms in individuals with autism spectrum disorder (ASD). Our study investigated the effects of a two-week regimen of tDCS targeting the left dorsolateral prefrontal cortex (DLPFC) in children with ASD, examining changes in rhythmic brain activity and alterations in functional connectivity within key neural networks: the default mode network (DMN), sensorimotor network (SMN), and dorsal attention network (DAN). Methods: We enrolled twenty-six children with ASD and assigned them randomly to either an active stimulation group (n=13) or a sham stimulation group (n=13). The active group received tDCS at an intensity of 1mA to the left DLPFC for a combined duration of 10 days. Differences in electrical brain activity were pinpointed using standardized low-resolution brain electromagnetic tomography (sLORETA), while functional connectivity was assessed via lagged phase synchronization. Results: Compared to the typically developing children, children with ASD exhibited lower current source density across all frequency bands. Post-treatment, the active stimulation group demonstrated a significant increase in both current source density and resting state network connectivity. Such changes were not observed in the sham stimulation group. Conclusion: tDCS targeting the DLPFC may bolster brain functional connectivity in patients with ASD, offering a substantive groundwork for potential clinical applications.
ABSTRACT
The Moon is the closest natural satellite to mankind, with valuable resources on it, and is an important base station for mankind to enter deep space. How to establish a reasonable lunar Global Navigation Satellite System (GNSS) to provide real-time positioning, navigation, and timing (PNT) services for Moon exploration and development has become a hot topic for many international scholars. Based on the special spatial configuration characteristics of Libration point orbits (LPOs), the coverage capability of Halo orbits and Distant Retrograde Orbit (DRO) in LPOs is discussed and analyzed in detail. It is concluded that the Halo orbit with a period of 8 days has a better coverage effect on the lunar polar regions and the DRO has a more stable coverage effect on the lunar equatorial regions, and the multi-orbital lunar GNSS constellation with the optimized combination of DRO and Halo orbits is proposed by combining the advantages of both. This multi-orbital constellation can make up for the fact that a single type of orbit requires a larger number of satellites to fully cover the Moon, using a smaller number of satellites for the purpose of providing PNT services to the entire lunar surface. We designed simulation experiments to test whether the multi-orbital constellations meet the full lunar surface positioning requirements, and compare the coverage, positioning, and occultation effects of the four constellation designs that pass the test, and finally obtain a set of well-performing lunar GNSS constellations. The results indicate that the multi-orbital lunar GNSS constellation combining DRO and Halo orbits can cover 100% of the Moon surface, provides there are more than 4 visible satellites at any time on the Moon surface, which meets the navigation and positioning requirements, and the Position Dilution of Precision (PDOP) value is stable within 2.0, which can meet the demand for higher precision Moon surface navigation and positioning.
