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1.
Br J Neurosurg ; 37(3): 439-441, 2023 Jun.
Article in English | MEDLINE | ID: mdl-30688109

ABSTRACT

BACKGROUND: The basic endoscopic instruments are not suitable for removing calcified or hard discs in patients with thoracic disc herniations (TDH). We describe a percutaneous endoscopic technique for the treatment of calcified TDH using an endoscopic drill system with a T rigid bendable burr. METHODS: Eleven patients (8 males, mean age 42.1 years) with single-segmental calcified TDH were treated with percutaneous endoscopic surgeries. RESULTS: Our technique using this endoscopic drill system with a T rigid bendable burr is safe and effective for the treatment of calcified TDH. CONCLUSIONS: Percutaneous endoscopic decompression using the T rigid bendable burr is a safe and reproducible surgical procedure for the treatment of calcified TDH.


Subject(s)
Intervertebral Disc Displacement , Male , Humans , Adult , Intervertebral Disc Displacement/diagnostic imaging , Intervertebral Disc Displacement/surgery , Decompression, Surgical/methods , Treatment Outcome , Lumbar Vertebrae/surgery , Endoscopy/methods , Thoracic Vertebrae/surgery , Retrospective Studies
2.
Bull Environ Contam Toxicol ; 96(2): 203-9, 2016 Feb.
Article in English | MEDLINE | ID: mdl-26499325

ABSTRACT

The present study investigated the photolytic behavior and photodegradation products of mefenamic acid (MEF) under ultraviolet-C irradiation. The results demonstrated that the photodegradation of MEF followed pseudo-first-order kinetics and the direct photolysis quantum yield of mefenamic acid was observed to be 2.63 ± 0.28 × 10⁻³. Photodegradation of MEF included degradation by direct photolysis and by self-sensitization that the contribution rates of self-sensitized photodegradation were 5.70, 11.25 and 18.96 % for ·OH, ¹O2 and O·2⁻ , respectively. Primary transformation products of MEF were identified using ultra performance liquid chromatography and quadrupole time-of-flight mass spectrometer (UPLC-Q-TOF-MS). The identified transformation products suggested three possible pathways of MEF photodegradation: dehydrogenation, hydroxylation, and ketonized reactions. Toxicity of phototransformation products were evaluated using the Microtox test, which revealed that photodegradation likely provides a critical pathway for MEF toxicity reduction in drinking water and wastewater treatment facilities.


Subject(s)
Mefenamic Acid/chemistry , Water Pollutants, Chemical/chemistry , Water/chemistry , Kinetics , Mass Spectrometry , Mefenamic Acid/analysis , Mefenamic Acid/radiation effects , Photolysis , Ultraviolet Rays , Water Pollutants, Chemical/analysis , Water Pollutants, Chemical/radiation effects
3.
Bull Environ Contam Toxicol ; 94(4): 479-83, 2015 Apr.
Article in English | MEDLINE | ID: mdl-25680932

ABSTRACT

The photodegradation of ibuprofen (IBP) in aqueous media was studied in this paper. The degradation mechanism, the reaction kinetics and toxicity of the photolysis products of IBP under UV-Vis irradiation were investigated by dissolved oxygen experiments, quenching experiments of reactive oxygen species (ROS), and toxicity evaluation utilizing Vibrio fischeri. The results demonstrated that the IBP degradation process could be fitted by the pseudo first-order kinetics model. The degradation of IBP by UV-Vis irradiation included direct photolysis and self-sensitization via ROS. The presence of dissolved oxygen inhibited the photodegradation of IBP, which indicated that direct photolysis was more rapid than the self-sensitization. The contribution rates of ·OH and (1)O2 were 21.8 % and 38.6 % in self-sensitization, respectively. Ibuprofen generated a number of intermediate products that were more toxic than the base compound during photodegradation.


Subject(s)
Ibuprofen/chemistry , Ibuprofen/toxicity , Ultraviolet Rays , Water Pollutants, Chemical/chemistry , Water Pollutants, Chemical/toxicity , Aliivibrio fischeri/drug effects , Ibuprofen/analysis , Kinetics , Oxygen/chemistry , Photochemical Processes , Photolysis , Reactive Oxygen Species/metabolism , Toxicity Tests , Water Pollutants, Chemical/analysis
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