1.
Bioorg Med Chem Lett
; 20(6): 1961-4, 2010 Mar 15.
Article
in English
| MEDLINE
| ID: mdl-20171096
ABSTRACT
A kind of racemic furan lignans were synthesized via a novel route, and two optical isomers were obtained through a selective hydrolization. The absolute configurations were determined by circular dichroism spectroscopy after separated through a preparative column. The different activities of isomers and the racemates were evaluated on QGY-7701 and HeLa cell lines, and compound 2c showed the best activity on QGY-7701 and HeLa cell lines with IC(50) 12 microM and 13 microM, respectively.