Chinese visceral adiposity index and its transition patterns: impact on cardiovascular and cerebrovascular diseases in a national cohort study.

BACKGROUND: Obesity affects approximately 800 million people worldwide and may contribute to various diseases, especially cardiovascular and cerebrovascular conditions. Fat distribution and content represent two related yet distinct axes determining the impact of adipose tissue on health. Unlike traditional fat measurement indices, which often overlook fat distribution, the Chinese visceral adiposity index (CVAI) is a novel metric used to assess visceral fat accumulation and associated health risks. Our objective is to evaluate its association with the risk of cardiovascular and cerebrovascular diseases. METHODS: A nationwide longitudinal study spanning 9 years was conducted to investigate both the effects of baseline CVAI levels (classified as low and high) and dynamic changes in CVAI over time, including maintenance of low CVAI, transition from low to high, transition from high to low, and maintenance of high CVAI. Continuous scales (restricted cubic spline curves) and categorical scales (Kaplan-Meier curves and multivariable Cox regression analyses) were utilized to evaluate the relationship between CVAI and cardiovascular and cerebrovascular diseases. Furthermore, subgroup analyses were conducted to investigate potential variations. RESULTS: Totally 1761 individuals (22.82%) experienced primary outcomes among 7717 participants. In the fully adjusted model, for each standard deviation increase in CVAI, there was a significant increase in the risk of primary outcomes [1.20 (95%CI: 1.14-1.27)], particularly pronounced in the high CVAI group [1.38 (95%CI: 1.25-1.54)] compared to low CVAI group. Regarding transition patterns, individuals who consistently maintained high CVAI demonstrated the highest risk ratio compared to those who consistently maintained low CVAI [1.51 (95%CI: 1.31-1.74)], followed by individuals transitioning from low to high CVAI [1.22 (95% CI: 1.01-1.47)]. Analysis of restricted cubic spline curves indicated a positive dose-response relationship between CVAI and risk of primary outcomes (p for non-linear = 0.596). Subgroup analyses results suggest that middle-aged individuals with high CVAI face a notably greater risk of cardiovascular and cerebrovascular diseases in contrast to elderly individuals [1.75 (95% CI: 1.53-1.99)]. CONCLUSION: This study validates a significant association between baseline levels of CVAI and its dynamic changes with the risk of cardiovascular and cerebrovascular diseases. Vigilant monitoring and effective management of CVAI significantly contribute to early prevention and risk stratification of cardiovascular and cerebrovascular diseases.

Computer Vision Technology for Monitoring of Indoor and Outdoor Environments and HVAC Equipment: A Review.

Artificial intelligence technologies such as computer vision (CV), machine learning, Internet of Things (IoT), and robotics have advanced rapidly in recent years. The new technologies provide non-contact measurements in three areas: indoor environmental monitoring, outdoor environ-mental monitoring, and equipment monitoring. This paper summarizes the specific applications of non-contact measurement based on infrared images and visible images in the areas of personnel skin temperature, position posture, the urban physical environment, building construction safety, and equipment operation status. At the same time, the challenges and opportunities associated with the application of CV technology are anticipated.

Automatic identification of pavement cracks in public roads using an optimized deep convolutional neural network model.

The current study aims to improve the efficiency of automatic identification of pavement distress and improve the status quo of difficult identification and detection of pavement distress. First, the identification method of pavement distress and the types of pavement distress are analysed. Then, the design concept of deep learning in pavement distress recognition is described. Finally, the mask region-based convolutional neural network (Mask R-CNN) model is designed and applied in the recognition of road crack distress. The results show that in the evaluation of the model's comprehensive recognition performance, the highest accuracy is 99%, and the lowest accuracy is 95% after the test and evaluation of the designed model in different datasets. In the evaluation of different crack identification and detection methods, the highest accuracy of transverse crack detection is 98% and the lowest accuracy is 95%. In longitudinal crack detection, the highest accuracy is 98% and the lowest accuracy is 92%. In mesh crack detection, the highest accuracy is 98% and the lowest accuracy is 92%. This work not only provides an in-depth reference for the application of deep CNNs in pavement distress recognition but also promotes the improvement of road traffic conditions, thus contributing to the progression of smart cities in the future. This article is part of the theme issue 'Artificial intelligence in failure analysis of transportation infrastructure and materials'.

DETHACDA: A Dual-view Edge and Topology Hybrid Attention Model for CircRNA-Disease Associations Prediction.

There exists growing evidence that circRNAs are concerned with many complex diseases physiological processes and pathogenesis and may serve as critical therapeutic targets. Identifying disease-associated circRNAs through biological experiments is time-consuming, and designing an intelligent, precise calculation model is essential. Recently, many models based on graph technology have been proposed to predict circRNA-disease association. However, most existing methods only capture the neighborhood topology of the association network and ignore the complex semantic information. Therefore, we propose a Dual-view Edge and Topology Hybrid Attention model for predicting CircRNA-Disease Associations (DETHACDA), effectively capturing the neighborhood topology and various semantics of circRNA and disease nodes in a heterogeneous network. The 5-fold cross-validation experiments on circRNADisease indicate that the proposed DETHACDA achieves the area under receiver operating characteristic curve of 0.9882, better than four state-of-the-art calculation methods.

Deep Learning-Empowered Clinical Big Data Analytics in Healthcare Digital Twins.

With the rapid development of information technology, great changes have taken place in the way of managing, analyzing, and using data in all walks of life. Using deep learning algorithm for data analysis in the field of medicine can improve the accuracy of disease recognition. The purpose is to realize the intelligent medical service mode of sharing medical resources among many people under the dilemma of limited medical resources. Firstly, the Digital Twins module in the Deep Learning algorithm is used to establish the medical care and disease auxiliary diagnosis model. With the help of the digital visualization model of Internet of Things technology, data is collected at the client and server. Based on the improved Random Forest algorithm, the demand analysis and target function design of the medical and health care system are carried out. Based on data analysis, the medical and health care system is designed using the improved algorithm. The results show that the intelligent medical service platform can collect and analyze the clinical trial data of patients. The accuracy of improved ReliefF & Wrapper Random Forest (RW-RF) for sepsis disease recognition can reach about 98%, and the accuracy of algorithm for disease recognition is also more than 80%, which can provide better technical support for disease recognition and medical care services. It provides a solution and experimental reference for the practical problem of scarce medical resources.

Digital Twins in Industry 5.0.

This work aims to explore the impact of Digital Twins Technology on industrial manufacturing in the context of Industry 5.0. A computer is used to search the Web of Science database to summarize the Digital Twins in Industry 5.0. First, the background and system architecture of Industry 5.0 are introduced. Then, the potential applications and key modeling technologies in Industry 5.0 are discussd. It is found that equipment is the infrastructure of industrial scenarios, and the embedded intelligent upgrade for equipment is a Digital Twins primary condition. At the same time, Digital Twins can provide automated real-time process analysis between connected machines and data sources, speeding up error detection and correction. In addition, Digital Twins can bring obvious efficiency improvements and cost reductions to industrial manufacturing. Digital Twins reflects its potential application value and subsequent potential value in Industry 5.0 through the prospect. It is hoped that this relatively systematic overview can provide technical reference for the intelligent development of industrial manufacturing and the improvement of the efficiency of the entire business process in the Industrial X.0 era.

Wi-Breath: A WiFi-Based Contactless and Real-Time Respiration Monitoring Scheme for Remote Healthcare.

Respiration rate is an important healthcare indicator, and it has become a popular research topic in remote healthcare applications with Internet of Things. Existing respiration monitoring systems have limitations in terms of convenience, comfort, and privacy, etc. This paper presents a contactless and real-time respiration monitoring system, the so-called Wi-Breath, based on off-the-shelf WiFi devices. The system monitors respiration with both the amplitude and phase difference of the WiFi channel state information (CSI), which is sensitive to human body micro movement. The phase information of the CSI signal is considered and both the amplitude and phase difference are used. For better respiration detection accuracy, a signal selection method is proposed to select an appropriate signal from the amplitude and phase difference based on a support vector machine (SVM) algorithm. Experimental results demonstrate that the Wi-Breath achieves an accuracy of 91.2% for respiration detection, and has a 17.0% reduction in average error in comparison with state-of-the-art counterparts.

Popular deep learning algorithms for disease prediction: a review.

Due to its automatic feature learning ability and high performance, deep learning has gradually become the mainstream of artificial intelligence in recent years, playing a role in many fields. Especially in the medical field, the accuracy rate of deep learning even exceeds that of doctors. This paper introduces several deep learning algorithms: Artificial Neural Network (NN), FM-Deep Learning, Convolutional NN and Recurrent NN, and expounds their theory, development history and applications in disease prediction; we analyze the defects in the current disease prediction field and give some current solutions; our paper expounds the two major trends in the future disease prediction and medical field-integrating Digital Twins and promoting precision medicine. This study can better inspire relevant researchers, so that they can use this article to understand related disease prediction algorithms and then make better related research.

MSHGANMDA: Meta-Subgraphs Heterogeneous Graph Attention Network for miRNA-Disease Association Prediction.

MicroRNAs (miRNAs) influence several biological processes involved in human disease. Biological experiments for verifying the association between miRNA and disease are always costly in terms of both money and time. Although numerous biological experiments have identified multi-types of associations between miRNAs and diseases, existing computational methods are unable to sufficiently mine the knowledge in these associations to predict unknown associations. In this study, we innovatively propose a heterogeneous graph attention network model based on meta-subgraphs (MSHGANMDA) to predict the potential miRNA-disease associations. Firstly, we define five types of meta-subgraph from the known miRNA-disease associations. Then, we use meta-subgraph attention and meta-subgraph semantic attention to extract features of miRNA-disease pairs within and between these five meta-subgraphs, respectively. Finally, we apply a fully-connected layer (FCL) to predict the scores of unknown miRNA-disease associations and cross-entropy loss to train our model end-to-end. To evaluate the effectiveness of MSHGANMDA, we apply five-fold cross-validation to calculate the mean values of evaluation metrics Accuracy, Precision, Recall, and F1-score as 0.8595, 0.8601, 0.8596, and 0.8595, respectively. Experiments show that our model, which primarily utilizes multi-types of miRNA-disease association data, gets the greatest ROC-AUC value of 0.934 when compared to other state-of-the-art approaches. Furthermore, through case studies, we further confirm the effectiveness of MSHGANMDA in predicting unknown diseases.

Dual-Channel Neural Network for Atrial Fibrillation Detection From a Single Lead ECG Wave.

With the dramatic progress of wearable devices, continuous collection of single lead ECG wave is able to be implemented in a comfortable fashion. Data mining on single lead ECG wave is therefore attracting increasing attention, where atrial fibrillation (AF) detection is a hot topic. In this paper, we propose a dual-channel neural network for AF detection from a single lead ECG wave. Two primary phases are included, the data preprocessing part followed by a dual-channel neural network. A two-stage denoising procedure is developed for data preprocessing, so as to tackle the high noise and disturbance which generally resides in the ECG wave collected by wearable devices. Then the time-frequency spectrum and Poincare plot of the denoised ECG signal are imported into the developed dual-channel neural network for feature extraction and AF detection. On the 2017 PhysioNet/CinC Challenge database, the F1 values were 0.83, 0.90, and 0.75 for AF rhythm and normal rhythm, and other rhythm, respectively. The results well validate the effectiveness of the proposed method for AF detection from a single lead ECG wave, and also indicate its performance advantages over some state-of-the-art counterparts.

A Pseudo-Siamese Feature Fusion Generative Adversarial Network for Synthesizing High-Quality Fetal Four-Chamber Views.

Four-chamber (FC) views are the primary ultrasound(US) images that cardiologists diagnose whether the fetus has congenital heart disease (CHD) in prenatal diagnosis and screening. FC views intuitively depict the developmental morphology of the fetal heart. Early diagnosis of fetal CHD has always been the focus and difficulty of prenatal screening. Furthermore, deep learning technology has achieved great success in medical image analysis. Hence, applying deep learning technology in the early screening of fetal CHD helps improve diagnostic accuracy. However, the lack of large-scale and high-quality fetal FC views brings incredible difficulties to deep learning models or cardiologists. Hence, we propose a Pseudo-Siamese Feature Fusion Generative Adversarial Network (PSFFGAN), synthesizing high-quality fetal FC views using FC sketch images. In addition, we propose a novel Triplet Generative Adversarial Loss Function (TGALF), which optimizes PSFFGAN to fully extract the cardiac anatomical structure information provided by FC sketch images to synthesize the corresponding fetal FC views with speckle noises, artifacts, and other ultrasonic characteristics. The experimental results show that the fetal FC views synthesized by our proposed PSFFGAN have the best objective evaluation values: SSIM of 0.4627, MS-SSIM of 0.6224, and FID of 83.92, respectively. More importantly, two professional cardiologists evaluate healthy FC views and CHD FC views synthesized by our PSFFGAN, giving a subjective score that the average qualified rate is 82% and 79%, respectively, which further proves the effectiveness of the PSFFGAN.

Cardiac LGE MRI Segmentation With Cross-Modality Image Augmentation and Improved U-Net.

Image segmentation is a challenging problem in imaging informatics, which stems from the intersection of imaging techniques, computer science and biomedicine. In particular, accurate segmentation of cardiac structures in late gadolinium enhancement (LGE) cardiac magnetic resonance (CMR) is of great clinical importance for cardiac function assessment and myocardial disease diagnosis. However, it is a well-known challenge due to its special imaging modality and the lack of labeled LGE samples. In this paper, we propose an unsupervised ventricular segmentation algorithm that can perform biventricular segmentation of LGE images in the absence of labeled LGE data. There are two primary modules, the data augmentation procedure and the segmentation network. The easily available annotated balanced-Steady State Free Precession (bSSFP) images are employed for cross-modal data augmentation by image translation, where a single bSSFP image is converted into multiple synthetic LGE images while preserving the original morphological structure. Then, the proposed segmentation network is trained with the synthetic LGE images and used for segmenting real LGE images. Validation experiments demonstrated the effectiveness and advantages of the proposed algorithm.

Deep Transfer Learning-Based Multi-Modal Digital Twins for Enhancement and Diagnostic Analysis of Brain MRI Image.

OBJECTIVE: it aims to adopt deep transfer learning combined with Digital Twins (DTs) in Magnetic Resonance Imaging (MRI) medical image enhancement. METHODS: MRI image enhancement method based on metamaterial composite technology is proposed by analyzing the application status of DTs in medical direction and the principle of MRI imaging. On the basis of deep transfer learning, MRI super-resolution deep neural network structure is established. To address the problem that different medical imaging methods have advantages and disadvantages, a multi-mode medical image fusion algorithm based on adaptive decomposition is proposed and verified by experiments. RESULTS: the optimal Peak Signal to Noise Ratio (PSNR) of 34.11dB can be obtained by introducing modified linear element and loss function of deep transfer learning neural network structure. The Structural Similarity Coefficient (SSIM) is 85.24%. It indicates that the MRI truthfulness and sharpness obtained by adding composite metasurface are improved greatly. The proposed medical image fusion algorithm has the highest overall score in the subjective evaluation of the six groups of fusion image results. Group III had the highest score in Magnetic Resonance Imaging- Positron Emission Computed Tomography (MRI-PET) image fusion, with a score of 4.67, close to the full score of 5. As for the objective evaluation in group I of Magnetic Resonance Imaging- Single Photon Emission Computed Tomography (MRI-SPECT) images, the Root Mean Square Error (RMSE), Relative Average Spectral Error (RASE) and Spectral Angle Mapper (SAM) are the highest, which are 39.2075, 116.688, and 0.594, respectively. Mutual Information (MI) is 5.8822. CONCLUSION: the proposed algorithm has better performance than other algorithms in preserving spatial details of MRI images and color information direction of SPECT images, and the other five groups have achieved similar results.

Application of Digital Twins and Metaverse in the Field of Fluid Machinery Pumps and Fans: A Review.

Digital twins technology (DTT) is an application framework with breakthrough rules. With the deep integration of the virtual information world and physical space, it becomes the basis for realizing intelligent machining production lines, which is of great significance to intelligent processing in industrial manufacturing. This review aims to study the application of DTT and the Metaverse in fluid machinery in the past 5 years by summarizing the application status of pumps and fans in fluid machinery from the perspective of DTT and the Metaverse through the collection, classification, and summary of relevant literature in the past 5 years. The research found that in addition to relatively mature applications in intelligent manufacturing, DTT and Metaverse technologies play a critical role in the development of new pump products and technologies and are widely used in numerical simulation and fault detection in fluid machinery for various pumps and other fields. Among fan-type fluid machinery, twin fans can comprehensively use technologies, such as perception, calculation, modeling, and deep learning, to provide efficient smart solutions for fan operation detection, power generation visualization, production monitoring, and operation monitoring. Still, there are some limitations. For example, real-time and accuracy cannot fully meet the requirements in the mechanical environment with high-precision requirements. However, there are also some solutions that have achieved good results. For instance, it is possible to achieve significant noise reduction and better aerodynamic performance of the axial fan by improving the sawtooth parameters of the fan and rearranging the sawtooth area. However, there are few application cases of the Metaverse in fluid machinery. The cases are limited to operating real equipment from a virtual environment and require the combination of virtual reality and DTT. The application effect still needs further verification.

SPReCHD: Four-Chamber Semantic Parsing Network for Recognizing Fetal Congenital Heart Disease in Medical Metaverse.

Echocardiography is essential for evaluating cardiac anatomy and function during early recognition and screening for congenital heart disease (CHD), a widespread and complex congenital malformation. However, fetal CHD recognition still faces many difficulties due to instinctive fetal movements, artifacts in ultrasound images, and distinctive fetal cardiac structures. These factors hinder capturing robust and discriminative representations from ultrasound images, resulting in CHD's low prenatal detection rate. Hence, we propose a multi-scale gated axial-transformer network (MSGATNet) to capture fetal four-chamber semantic information. Then, we propose a SPReCHD: four-chamber semantic parsing network for recognizing fetal CHD in the clinical treatment of the medical metaverse, integrating MSGATNet to segment and locate four-chamber arbitrary contours, further capturing distinguished representations for the fetal heart. Comprehensive experiments indicate that our SPReCHD is sufficient in recognizing fetal CHD, achieving a precision of 95.92%, a recall of 94%, an accuracy of 95%, and a F1 score of 94.95% on the test set, dramatically improving the fetal CHD's prenatal detection rate.

Low-Cost and Confidential ECG Acquisition Framework Using Compressed Sensing and Chaotic Systems for Wireless Body Area Network.

Recent years have witnessed an increasing popularity of wireless body area network (WBAN), with which continuous collection of physiological signals can be conveniently performed for healthcare monitoring. Energy consumption is a critical issue because it directly affects the duration of the equipped sensors. In this article, we propose a low-cost and confidential electrocardiogram (ECG) acquisition approach for WBAN. The compressed sensing (CS) is employed for low-cost signal acquisition, and its cryptographic features are exploited for promoting the framework's confidentiality. In particular, the RIPless measurement matrix is used to give CS the resistance against plaintext attack, while the first-order Σ∆ quantizer is employed to embed the cryptographic diffusion feature into the whole system. Two chaotic systems are employed for generating the required secret elements for the acquisition and encryption. Experiment results well demonstrate the signal reconstruction and security performance of the proposed framework.

DDCNN: A Deep Learning Model for AF Detection From a Single-Lead Short ECG Signal.

With the popularity of the wireless body sensor network, real-time and continuous collection of single-lead electrocardiogram (ECG) data becomes possible in a convenient way. Data mining from the collected single-lead ECG waves has therefore aroused extensive attention worldwide, where early detection of atrial fibrillation (AF) is a hot research topic. In this paper, a two-channel convolutional neural network combined with a data augmentation method is proposed to detect AF from single-lead short ECG recordings. It consists of three modules, the first module denoises the raw ECG signals and produces 9-s ECG signals and heart rate (HR) values. Then, the ECG signals and HR rate values are fed into the convolutional layers for feature extraction, followed by three fully connected layers to perform the classification. The data augmentation method is used to generate synthetic signals to enlarge the training set and increase the diversity of the single-lead ECG signals. Validation experiments and the comparison with state-of-the-art studies demonstrate the effectiveness and advantages of the proposed method.

BlockNet: Beyond reliable spatial Digital Twins to Parallel Metaverse.

The development of Digital Twins has enabled them to be widely applied to various fields represented by intelligent manufacturing. A Metaverse, which is parallel to the physical world, needs mature and secure Digital Twins technology in addition to Parallel Intelligence to enable it to evolve autonomously. We propose that Blockchain combined with other areas does not simultaneously require all of the basic elements. We extract the immutable characteristics of Blockchain and propose a secure multidimensional data storage solution called BlockNet that can ensure the security of the digital mapping process of the Internet of Things, thereby improving the data reliability of Digital Twins. Additionally, to address some of the challenges faced by multiscale spatial data processing, we propose a nonmutagenic multidimensional Hash Geocoding method, allowing unique indexing of multidimensional information and avoiding information loss due to data dimensionality reduction while improving the efficiency of information retrieval and facilitating the implementation of the Metaverse through spatial Digital Twins based on these two studies.

Practical Machine Learning Model to Predict the Recovery of Motor Function in Patients with Stroke.

BACKGROUND: Machine learning (ML) is an artificial intelligence technique in which a system learns patterns and rules from a given data. OBJECTIVES: The objective of the study was to investigate the potential of ML for predicting motor recovery in stroke patients. METHODS: We analyzed data from 833 consecutive stroke patients using 3 ML algorithms: deep neural network (DNN), random forest, and logistic regression. We created a practical ML model using the most common data measured in almost all rehabilitation hospitals as input data. Demographic and clinical data, including modified Brunnstrom classification (MBC) and functional ambulation classification (FAC), were collected when patients were transferred to the rehabilitation unit (8-30 days) and 6 months after stroke onset and were used as input data. Motor outcomes at 6 months after stroke onset of the affected upper and lower extremities were classified according to MBC and FAC, respectively. Patients with an MBC of <5 and an FAC of <4 at 6 months after stroke onset were considered to have a "poor" outcome, whereas those with MBC ≥5 and FAC ≥4 were considered to have a "good" outcome. RESULTS: The area under the curve (AUC) for the DNN model for predicting motor function was 0.836 for the upper and lower limb motor functions. For the random forest and logistic regression models, the AUCs were 0.736 and 0.790 for the upper and lower limb motor functions, respectively. The AUCs for the random forest and logistic regression models were 0.741 and 0.795 for the upper and lower limb motor functions, respectively. CONCLUSION: Although we used simple and common data that can be obtained in clinical practice as variables, our DNN algorithm was useful for predicting motor recovery of the upper and lower extremities in stroke patients during the recovery phase.

Application of Digital Twins in multiple fields.

With the development of science and technology, the high-tech industry is developing rapidly, and various new-age technologies continue to appear, and Digital Twins (DT) is one of them. As a brand-new interactive technology, DT technology can handle the interaction between the real world and the virtual world well. It has become a hot spot in the academic circles of all countries in the world. DT have developed rapidly in recent years result from centrality, integrity and dynamics. It is integrated with other technologies and has been applied in many fields, such as smart factory in industrial production, digital model of life in medical field, construction of smart city, security guarantee in aerospace field, immersive shopping in commercial field and so on. The introduction of DT is mostly a summary of concepts, and few practical applications of Digital Twins are introduced. The purpose of this paper is to enable people to understand the application status of DT technology. At the same time, the introduction of core technologies related to DT is interspersed in the application introduction. Finally, combined with the current development status of DT, predict the future development trend of DT and make a summary.