ABSTRACT
Respiratory syncytial virus (RSV) infection is a major cause of pneumonia in adults. Little is known on the viral genetic diversity and the associated clinical phenotypes in this population. This single-center prospective cohort study included RSV-infected patients hospitalized between January 2019 and December 2022. Of 100 patients, including 41 with severe infection, 72 were infected with RSV-B. RSV genome sequencing showed no clustering according to severity. Patients infected with RSV-B with risk factors for severe pneumonia had significantly higher fusion protein diversity scores. No amino acid substitutions conferring resistance to nirsevimab were detected.
Subject(s)
Pneumonia , Respiratory Syncytial Virus Infections , Respiratory Syncytial Virus, Human , Adult , Humans , Infant , Prospective Studies , Respiratory Syncytial Virus, Human/genetics , PhenotypeSubject(s)
Eccrine Glands/pathology , Hamartoma/pathology , Hemangioma/pathology , Sweat Gland Diseases/pathology , Humans , MaleABSTRACT
Epidermal growth cell receptors (EGFR) play a key role in tumor proliferation. Their inhibitors (anti-EGFR) are promising treatments for various types of cancers. Papulopustular follicular eruptions are the most frequent dermatological side effect and occur in 45 to 85% of patients receiving this treatment. Paronychias appear after several weeks of treatment. They are painful and impair hand and foot function. A positive correlation seems to exist between the intensity of the papulo-follicular eruption, tumor regression and survival.