[CRITERIA OF DIFFERENCE EVALUATION FOR VARIOUS TYPES OF HEMORRHAGIC FEVER WITH RENAL SYNDROME FOCI. HFRS FOCI IN VARIOUS BIOTOPES OF TYPICAL BARRENS].

AIM: Examine features of natural, natural-anthropourgic and anthropourgic foci of hemorrhagic fever with renal syndrome (HFRS) in various, mostly forest, biotopes of typical barrens due to differences of non-specific HFRS prophylaxis in foci of various types. MATERIALS AND METHODS: Epizootological and epidemiologic data from 1998 to 2012 were analyzed, gathered in HFRS foci of all types in Saratov area of Saratov Region (typical barrens). 14,606 trap-nights were worked off and 2669 small mammals were procured. The most significant population-ecologic and ecologic-epizootological methods and criteria were used for comparative analysis of differences for 3 types of foci. RESULTS: Based on analysis of multi-year data seasonal differences for HFRS foci of various types were shown by 10 population-ecologic and ecologic-epizootologic criteria. CONCLUSION: The results obtained allow to state that modern means and methods of non-specific prophylaxis of HFRS and other zoonoses in foci of various types different significantly. This allows the most rational use of material and financial resources.

[Criteria of difference evaluation for-various types of hemorrhagic fever with renal syndrome foci. HFRS foci in various biotopes of northern barrens].

AIM: Determine qualitative and quantitative criteria of evaluation of features for natural, natural-anthropourgic and anthropourgic foci of hantaviruses (using hemorrhagic fever with renal syndrome--HFRS foci as an example), that have formed in various areas of Saratov Region. MATERIALS AND METHODS: Epizootological and epidemiologic data from 1998 to 2012 were analyzed. During this period in all the types of foci of Atkarsk area (Northern barrens) 13,004 trap-nights were worked off, 2577 small mammals were procured. Genetic, population-ecological and ecological-epizootological methods and criteria were used for comparative analysis of 3 types of loci: PCR diagnostics and sequencing of pathogenic for humans hantaviruses, species cadaster and features of season dynamics of species composition of hantavirus carriers, domination indexes, parameters of quantity and infection of carriers by hantaviruses; distribution of the latter by biotopes, degree and character of population contacts with natural-foci complexes, epizootic potential of foci. RESULTS: Based on multi-year data analysis features of 3 types of HFRS foci were shown in various, mostly forest, biotopes of Northern and a part of typical barrens. A stable domination of Pumala genotype hantavirus was noted; a weakly expressed circulation in parasite systems with Apodemus genus carriers, first of all Dobrava genotype Apodemus agrarius, was established as well. CONCLUSION: A certain specter of most universal criteria;that are closely interconnected, are necessary during typing of HFRS foci and a number of other zoonozes.

[Topical issues of biological safety under current conditions. Part 3. Scientific provision for the national regulation of the biological safety framework in its broad interpretation].

Consequent of investigation concerned with biological safety (BS) framework development in its broad interpretation, reflected in the Russian Federation State Acts, identified have been conceptual entity parameters of the up-to-date broad interpretation of BS, which have formed a part of the developed by the authors system for surveillance (prophylaxis, localization, indication, identification, and diagnostics) and control (prophylaxis, localization, and response/elimination) over the emergency situations of biological (sanitary-epidemiological) character. The System functionality is activated through supplying the content with information data which are concerned with monitoring and control of specific internal and external threats in the sphere of BS provision fixed in the Supplement 2 of the International Health Regulations (IHR, 2005), and with the previously characterized nomenclature of hazardous biological factors. The system is designed as a network-based research-and-practice tool for evaluation of the situation in the sphere of BS provision, as well as assessment of efficacy of management decision making as regards BS control and proper State policy implementation. Most of the system elements either directly or indirectly relate to the scope of activities conducted by Federal Service for Surveillance in the Sphere of Consumers Rights Protection and Human Welfare, being substantial argument for allocating coordination functions in the sphere of BS provision to this government agency and consistent with its function as the State Coordinator on IHR (2005). The data collected serve as materials to Draft Federal Law "Concerning biological safety provision of the population".