[Influence of enzyme inducers and inhibitors of the metabolism of xenobiotics and of the coenzyme forms of vitamins B1 and B2 on the anti-inflammatory effect of voltaren]. / Vliianie induktorov i ingibitorov fermentov metabolizma ksenobiotikov, kofermentnykh form vitaminov B1 i B2 na protivovospalitel'nyi éffekt vol'tarena.

In experiments on 245 male rats there was studied the influence of an inductor of xenobiotic metabolism enzymes, phenobarbital, an inhibitor of microsomal monooxygenases, cobalt chloride, and also coenzyme forms of vitamins B1 and B2, thiamine diphosphate and flavin mononucleotide on the anti-inflammatory effect of voltaren evaluated according to inhibition of an increase of the limb edema, a decrease of pain sensitivity, the blood level of fucose and the liver level of malondialdehyde in rats with adjuvant arthritis. Phenobarbital weakens the anti-inflammatory action of voltaren but at the same time cobalt chloride and thiamine diphosphate potentiate the therapeutic effect of voltaren. Flavin mononucleotide fails to modify the effect of voltaren but decreases however its toxicity.

[Effect of various supplies of vitamin B2 in the rat body on the activity of enzymes participating in the metabolism of xenobiotics]. / Vliianie razlichnoi obespechennosti organizma krys vitaminom B2 na aktivnost' fermentov, uchastvuiushchikh v metabolizme chuzherodnykh veshchestv.

Studies on the effect of different content of vitamin B2 (alimentary deficiency, additional administration) in the rat organism on the activity of enzymes participating in the metabolism of foreign substances and on the inducing effect of phenobarbital have shown that vitamin B2 to a considerable extent controls the activity of flavin-containing enzymes participating in the metabolism of xenobiotics (D-amino acid oxidase, xanthine and aldehyde oxidases, NADH- and NADPH-reductase activity of neotetrazolium) and a number of enzymes for which flavins do not play the role of prosthetic group (esterases aldehyde and formaldehyde dehydrogenases, demethylase and hydroxylase). Different content of vitamin B2 in animal organism also influences the action of phenobarbital, an inductor of xenobiotics metabolism, and the acetanilide biotransformation rate.

[Vitamin A and E allowance of the body in xenobiotic exposure]. / Obespechennost' organizma vitaminami A i E pri deistvii ksenobiotikov.

The results are presented of the clinico-experimental studies conducted in patients with diseases of the respiratory organs. Providing with tocopherol, lipid metabolism and peroxidation parameters were studied in these patients in the time course of combined drug therapy. Different variants of providing with vitamins A and E were simulated in rats. It was shown that both under clinical and experimental conditions, administration of xenobiotics produced the devitaminizing effect which was manifest in tocopherol and retinol deficiency, activation of lipid peroxidation in the blood, bronchoalveolar lavage, in the lungs and liver. The authors have recommended the control over providing with vitamins A and E during the drug therapy of such patients, as well as differential approach to the corrective dietotherapy with the rations enriched with vitamins A and E; the vitamins are especially necessary for the patients with chronic broncho-pulmonary diseases in the presence of obesity and lipid metabolism disorders.