Effects of phosphoinositide cycle modifiers on apoptosis of peritoneal macrophages.

Hydrogen peroxide stimulates apoptosis of zymosan-activated rat peritoneal macrophages. Phosphoinositide cycle modifiers enhance the proapoptotic effect of H(2)O(2) in a concentration of 1 mM and necrosis-stimulating effect of H(2)O(2) in a concentration of 10 mM. Disorders in phosphoinositide metabolism and impaired reaction of the cell to proinflammatory agents are the cause of programmed cell death. Rejection of defective cells can be realized via variation of H(2)O(2) concentration.