Neurological disorders in pregnant women in low- and middle-income countries-Management gaps, impacts, and future prospects: A review perspective.

Neurological disorders during pregnancy are a substantial threat to women's health, particularly in low- and middle-income countries. Furthermore, a critical shortage of mental health workers and neurologists exacerbates the already pressing issue, where a lack of coordination of respective healthcare among multidisciplinary teams involved in managing these conditions perpetuates the current state of affairs. Financial restrictions and societal stigmas associated with neurological disorders in pregnancy amplify the situation. Addressing these difficulties would necessitate a multifaceted approach comprising investments in healthcare infrastructure, healthcare professional education and training, increased government support for research, and the implementation of innovative care models. Improving access to specialized treatment and coordinated management of antenatal neurological diseases will precipitate improved health outcomes for women and their families in low- and middle-income countries.

From adversity to advancement: leveraging war-tested approaches for the post-conflict reformation of the Ukrainian healthcare landscape.

The Russo-Ukrainian Conflict has had significant repercussions on Ukraine's healthcare system, resulting in civilian casualties and damage to healthcare institutions. The disruption of personnel, medical supplies, and patient transportation has created considerable challenges for healthcare services. However, there are successful approaches from comparable contexts that can serve as a catalyst for post-conflict healthcare reformation in Ukraine. Key strategies include improving healthcare accessibility for marginalized populations through standardized essential health and surgical care packages, rehabilitating damaged facilities, strengthening primary care provisions, and supporting war survivors with disabilities. By adopting these proven practices, Ukraine can strengthen its healthcare system and facilitate a sustainable recovery, contributing to the country's resilience and ensuring essential healthcare services for its population.

DIAGNOSTIC FEATURES OF DYSFUNCTION IN CYTOKINE AND SYMPATHOADRENAL SYSTEMS WITH ISCHEMIC STROKE.

OBJECTIVE: The aim: Was a comprehensive study of the changes in features like structural and functional parameters of brain tissue, cytokine profile and ß-adrenoceptor in the acute period of ischemic stroke (IS) to optimise diagnosis and treatment. The study was conducted at the Department of Neurosurgery and Neurology at the Medical Institute of Sumy State University. PATIENTS AND METHODS: Materials and methods: Measurements of complex dielectric constant (CDC) were performed by EHF dielectrometry. Determination of plasma levels of interleukin-6 (IL-6) and tumour necrosis factor-α (TNF-α) was performed by solid-phase enzyme-linked immunosorbent assay. The work was based on the materials of a comprehensive examination of 350 patients with the first in the life of IS on the 1st, 10th and 21st day of the disease. RESULTS: Results: Cerebral hypoxia leads to a significant increase in the CDC of erythrocyte membranes (about 15 %), which may lead to a rise in the volume fraction of water in cell suspensions due to damage of their membrane-receptor complex (MRC). The revealed connections between changes of CDC of patients with IS and decrease insensitivity of their MRC to adrenergic drugs testify in favour of damaging action of hypoxia. An imbalance in the cytokine system and their relationship to the sympathoadrenal system has been identified. CONCLUSION: Conclusions: There is a strong association of mechanisms that damage the MRC of cells during acute cerebral ischemia with functional changes in both the sympathoadrenal and cytokine systems. Identified links in the pathogenesis of IS should be used for early diagnosis of the disease.