[Effect of traumatic shock on the cytogenetic processes in the epithelial cells of the cornea and tongue and in the bone marrow cells of white rats]. / Vliianie tramaticheskogo shoka na tsitogeneticheskie protsessy v kletkakh épiteliia rogovitsy i iazyka i v kletkakh kostnogo mozga belykh krys.

Traumatic shock in male albino rats as induced by prolonged (4-hour) compression of soft tissues of the hind limbs. It was found that 3, 6 and 24 hours after the termination of compression the mitotic activity in the corneal epithelium decreased 9.8-, 4.7- and 3-fold, respectively. The level of pathological mitoses in experimental animals rose 2.4 - 3-fold. Experiments in colchicine demonstrated that inhibition of mitotic activity is not related to the changed rate of mitosis. In the tongue epithelium, the depression of cell division was revealed 3 and 6 hours after compression was terminated. The mitotic index fell 2.7- and 3.7-fold, respectively. Radioautography showed a significant decrease in DNA-synthetizing capacity of epithelial cells of the tongue 3 and 6 hours after the compression was terminated. Karyotypic analysis of bone marrow cells showed that chromosome aberrations increased 3.3-fold.