Subject(s)
Benzenesulfonates/toxicity , Detergents/toxicity , Stilbenes/toxicity , Animals , Benzenesulfonates/metabolism , Detergents/metabolism , Diet , Dogs , Female , Fluorescent Dyes/metabolism , Fluorescent Dyes/toxicity , Litter Size , Male , Pregnancy , Rats , Reproduction/drug effects , Species Specificity , Stilbenes/metabolism , Time FactorsABSTRACT
Compounds (1), (2), (3), and (4) caused no adverse toxic effects and yielded no evidence of carcinogenic activity in a 2-year feeding study in albino rats at dietary levels up to 1000 ppm. Compounds (2), (3) and (4) were without effect in a 2-year study in beagle dogs at levels up to 2000 ppm. Compound (1) at levels of 400 and 1000 ppm led to decreased weight gains in some dogs and caused doserelated pathology consisting of inflammatory changes on the serosal surfaces of abdominal viscera and increased hematopoietic acitivty of the spleen and liver cords. These effect could have been due to the feeding of material, without adjustment of pH, for the first 30 weeks of the study.
Subject(s)
Carcinogens/pharmacology , Coloring Agents/pharmacology , Aging , Animals , Biphenyl Compounds/pharmacology , Body Weight/drug effects , Coloring Agents/toxicity , Diet , Dogs , Female , Male , Organ Size/drug effects , Rats , Species Specificity , Stilbenes/pharmacology , Triazoles/pharmacologyABSTRACT
Four fluorescent whitening agents (FWAs), compounds (1), (2), (3) and (4) (see table 1) were investigated for their effects on the reproductive performance of albino rats through 3 successive 2-litter generations at dietary levels of 40, 200, and 1000 ppm. Except for slight and random effects of compound (4) on pup survival, no adverse effects were observed. The random effects with compound (4) were not consistently related to either dose level or cumulative duration of exposure through the 3 generations.
