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1.
Cureus ; 15(5): e38901, 2023 May.
Article in English | MEDLINE | ID: mdl-37313069

ABSTRACT

Infections due to nontuberculous mycobacteria (NTM) are caused by mycobacterial species other than Mycobacterium tuberculosis, M. leprae, and M. bovis. Patients who are immunocompromised have increased susceptibility to pulmonary, lymphatic, and skin infections by these pathogens. We present a case of a 78-year-old male who presented to dermatology with a left dorsolateral hand infection after sustaining cat scratches in the setting of topical steroid therapy for suspected pyoderma gangrenosum. A shave biopsy of the lesion showed granulomatous dermatitis and associated acid-fast bacilli, while tissue culture grew Mycobacterium chelonae. This case demonstrates cat scratches as an uncommon risk factor for cutaneous NTM disease. Although an association between cat scratches and human NTM infections has only been reported in two previous cases, it must be considered in cases of unusual and persistent cutaneous lesions, especially in immunocompromised patients, even those with only local immunosuppression from topical agents.

2.
J Investig Med High Impact Case Rep ; 10: 23247096221133989, 2022.
Article in English | MEDLINE | ID: mdl-36300426

ABSTRACT

Extrahepatic metastasis of hepatocellular carcinoma (HCC) to the head and neck is unusual, especially the oral cavity/maxillofacial region. Metastatic HCC to the hard palate, however, is particularly rare. The most common site of HCC metastasis is the lung, followed by lymph nodes, bone, and adrenal gland. Importantly, oral cavity metastatic HCC may be misdiagnosed as a primary malignancy, such as a salivary gland carcinoma. In this article, we describe a young woman with metastatic HCC to the hard palate that was initially diagnosed as an acinic cell carcinoma.


Subject(s)
Carcinoma, Acinar Cell , Carcinoma, Hepatocellular , Liver Neoplasms , Female , Humans , Carcinoma, Hepatocellular/diagnosis , Carcinoma, Hepatocellular/pathology , Carcinoma, Hepatocellular/secondary , Liver Neoplasms/pathology , Palate, Hard/pathology , Lymph Nodes/pathology , Carcinoma, Acinar Cell/pathology
3.
Cutis ; 110(5): 277-280, 2022 Nov.
Article in English | MEDLINE | ID: mdl-36638377

ABSTRACT

Perineuriomas are rare benign peripheral nerve sheath tumors that can present in a variety of locations with varying histologic patterns, most commonly in young to middle-aged adults; they are particularly rare in the pediatric population. Perineuriomas have a distinctive constellation of morphologic, immunohistochemical, and ultrastructural characteristics that allows for distinction from other benign peripheral nerve sheath tumors. We present 2 cases of perineuriomas that arose as cutaneous lesions in children.


Subject(s)
Nerve Sheath Neoplasms , Adult , Middle Aged , Humans , Child , Immunohistochemistry , Nerve Sheath Neoplasms/diagnosis , Nerve Sheath Neoplasms/pathology
4.
Cureus ; 13(11): e19256, 2021 Nov.
Article in English | MEDLINE | ID: mdl-34900456

ABSTRACT

Glomus tumors are rare, painful, and usually benign neoplasms that typically occur at the subungual aspect of digits. Rarely, glomus tumors may arise in other areas of the body. We present a case of an extradigital glomus tumor on a forearm with prior trauma that presented with symptoms of an isolated peripheral neuropathy. Our review of literature reveals how upper or lower extremity glomus tumors can mimic neuropathies secondary to intrinsic nerve tumors (schwannoma, neurofibroma, or neuroma), radiculopathies, or manifestations of a complex regional pain syndrome (CRPS). We emphasize the need to consider a broad differential diagnosis that includes glomus tumor when evaluating patients with painful dermal masses producing peripheral neuropathy or radiculopathy signs owing to the infiltrative growth pattern into or mass effect exerted on nearby nerves.

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