ABSTRACT
Basing on data of analysis of the hemostasis system state in the patients, suffering abdominal aorta aneurysm, a tendency for raising of postoperative soluble fibrin and D-dimer content in the blood plasm and reduction of these indices on the third day was noted. The abovementioned markers content depends on the aneurysm size, the fibrin deposits presence, the terms from clinical signs beginning to the certain therapy administration and anticoagulants application. Information about correlation between content of D-dimer and soluble fibrin in the treatment dynamics is important for determination of activation degree in the patients blood coagulation system and the thrombotic complications prognosis.
Subject(s)
Aorta, Abdominal/surgery , Aortic Aneurysm, Abdominal/blood , Fibrin Fibrinogen Degradation Products/analysis , Fibrin/analysis , Fibrinogen/analysis , Thrombosis/prevention & control , Anticoagulants/administration & dosage , Anticoagulants/therapeutic use , Aorta, Abdominal/drug effects , Aorta, Abdominal/pathology , Aortic Aneurysm, Abdominal/drug therapy , Aortic Aneurysm, Abdominal/pathology , Aortic Aneurysm, Abdominal/surgery , Blood Coagulation/drug effects , Blood Coagulation Tests , Humans , Male , Middle Aged , Prognosis , SolubilityABSTRACT
Separation and identification of phenylthiohydantoin derivatives (PTH) of 19 amino acids usually found in proteins was performed by thin-layer chromatography of "silufol" plates. Conditions of PTH quantitation were found at which a 90% extraction of PTH from silicagel was attained. A N-terminal analytical procedure for fibrin is elaborated, by which a high yield of N-terminal amino acids is obtained.
