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Zhonghua Yu Fang Yi Xue Za Zhi ; 57(11): 1895-1900, 2023 Nov 06.
Article in Chinese | MEDLINE | ID: mdl-38008583

ABSTRACT

Eosinophils are important immune cells that contain eosinophilic particles and play a key role in allergic diseases such as asthma and helminth infections. An increasing number of studies have confirmed that eosinophils infiltrate a variety of tumor tissues, which can synthesize and secrete a large number of bioactive substances under certain circumstances, such as cytotoxic cationic proteins, cytokines, growth factors, chemokines, enzymes and so on, which may affect angiogenesis and matrix remodeling or change the tumor microenvironment, thereby affecting tumor progression. This review focused on the role of eosinophils in lung cancer and provided an outlook on the issues in clinical and basic research.


Subject(s)
Asthma , Hypersensitivity , Lung Neoplasms , Humans , Eosinophils/metabolism , Eosinophils/pathology , Cytokines , Hypersensitivity/metabolism , Hypersensitivity/pathology , Asthma/metabolism , Asthma/pathology , Tumor Microenvironment
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