[The development of the methods for the extraction, identification, and quantitative determination of alimemazine in the biological fluids from the laboratory animals under the acute poisoning conditions]. / Razrabotka metodik izolirovaniia, obnaruzheniia i kolichestvennogo opredeleniia alimemazina v biologicheskikh zhidkostiakh laboratornykh zhivotnykh pri ostrykh otravleniiakh.

There is the present-day tendency toward prescribing atypical neuroleptics for the management of neurologic and psychic disorders. Alimemazine appears to be very frequently used for this purpose due to the broad spectrum of its actions. At the same time, cases of alimemazine poisoning with the fatal outcome have been described. The objective of the present study was determine alimemazine in the biological fluids from the laboratory animals under the acute poisoning conditions. The experiments were carried with the use of the Wistar rats having 200 g body weight. Alimemazine was isolated from their biological fluids (blood plasma and urine) using the liquid-liquid extraction techniques developed specially for the purpose of this study. Alimemazine was extracted and quantitatively determined by HPLC and HPLC/MS. The method for the isolation of alimemazine from the urine and blood plasma is described. The results of the study give evidence that the maximum amount of the substance of interest can be extracted from the blood plasma within 1 hour after the administration of the toxic dose of alimemazine and within 2 hours after the administration of its therapeutic dose. The maximum amount of alimemazine in the urine is found within 3 hours after the administration of its therapeutic dose to the laboratory animals. It is concluded that the proposed methods for the extraction of alimemazine from the biological fluids can be included in the scheme of the chemical toxicological analysis of this substance.

[Long-term results of the program «Point of Sobriety¼ in patients with alcohol dependence in the Krasnodar region]. / Otdalennye rezul'taty lecheniia patsientov s alkogol'noi zavisimost'iu po programme «Tochka trezvosti¼ v Krasnodarskom krae.

AIM: To analyze the long-term results of the «Point of Sobriety¼ program in patients with alcohol dependence. MATERIAL AND METHODS: It was analyzed the results of treatment of 104 patients treated 2 or more years before the current study. RESULTS AND CONCLUSION: The high efficacy of complex treatment with naltrexone injections was demonstrated. Remission during more than 1 year was achieved in 64.4% of patients, more than 2 years in 45.2%. Most patients reported improvement in social and family status.