ABSTRACT
Primary infiltrating ductal carcinomas (IDCs) of the breast which measure less than 0.5 cm (T1a lesions) and between 0.5 and 1.0 cm (T1b lesions) are associated with a small risk of nodal metastasis. The role of axillary dissection in T1a and T1b breast cancer is controversial. In the absence of axillary dissection, comparable prognostic information might be obtained by examination of the primary cancer. The adhesion molecule CD44 represents a family of transmembrane proteins that mediate cell-cell and cell-matrix interactions. Previous investigators have correlated expression of CD44 and its isoforms with prognosis in breast cancer. We investigated the value of CD44 isoform expression as a predictor of nodal metastases in nonpalpable T1a and T1b IDC. Monoclonal antibody against the standard form of CD44 (CD44s) and polyclonal antibody directed against the variant isoform (CD44v6) was tested on 34 cases of nonpalpable node-negative infiltrating ductal carcinoma (IDC) less than 1.0 cm and 9 cases of nonpalpable node-positive IDC less than 1.0 cm. The expression of CD44s was significantly decreased in node-positive T1a and T1b IDC versus node-negative T1a and T1b IDC (11% vs 65%). In contrast, 97% of the node-negative IDC and 100% of the node-positive IDC expressed the CD44v6 isoform. We conclude that CD44s expression is significantly altered in T1a and T1b IDC with nodal metastases but that the CD44v6 isoform does not correlate with nodal metastases in nonpalpable stage T1a and T1b IDC.
Subject(s)
Antigens, Neoplasm/metabolism , Breast Neoplasms/metabolism , Carcinoma, Ductal, Breast/metabolism , Hyaluronan Receptors/metabolism , Breast Neoplasms/pathology , Carcinoma, Ductal, Breast/pathology , Female , Humans , Immunohistochemistry , Lymphatic Metastasis , Prognosis , Reference ValuesABSTRACT
We report the fourth case of chondromyxoid fibroma of the sternum described in the literature. The clinical, radiographic, pathologic and treatment aspects of this case are presented, and the literature on chondromyxoid fibroma in this unusual location is reviewed.
Subject(s)
Chondroblastoma , Sternum , Thoracic Neoplasms , Adult , Chondroblastoma/diagnostic imaging , Chondroblastoma/pathology , Chondroblastoma/surgery , Female , Humans , Radiography , Sternum/diagnostic imaging , Sternum/pathology , Sternum/surgery , Thoracic Neoplasms/diagnostic imaging , Thoracic Neoplasms/pathology , Thoracic Neoplasms/surgeryABSTRACT
Opportunistic mycotic infections, such as aspergillosis, can produce morbid consequences with or without aggressive therapy in an immunocompromised patient. Treatment including amphotericin B and resection of the infected tissue must be considered early in the overall management of the patient. We describe two patients with acute myelogenous leukemia who underwent intense cytoreductive therapy with bone marrow transplantation and an associated fungal infection treated with an investigational form of amphotericin B.
Subject(s)
Aspergillosis/etiology , Immunocompromised Host , Leukemia, Myeloid, Acute/complications , Sinusitis/microbiology , Stomatitis/microbiology , Adult , Amphotericin B/therapeutic use , Antineoplastic Combined Chemotherapy Protocols/adverse effects , Aspergillosis/diagnostic imaging , Aspergillosis/drug therapy , Bone Marrow Transplantation/adverse effects , Female , Humans , Leukemia, Myeloid, Acute/therapy , Male , Oroantral Fistula/etiology , Sinusitis/drug therapy , Sinusitis/etiology , Stomatitis/drug therapy , Stomatitis/etiology , Tomography, X-Ray ComputedABSTRACT
We report a case of bilaterally multifocal renal oncocytomas in a patient with chronic renal disease and a long history of hypertension. Histologic study of the multiple oncocytic neoplasms with hematoxylin-eosin, periodic acid-Schiff, trichrome, and colloidal iron stains revealed novel, intracytoplasmic lumina, which were accentuated by immunoperoxidase staining with high-molecular-weight cytokeratin, epithelial membrane antigen, and Arachis hypogaea lectin. Ultrastructural studies demonstrated multiple microvilli lining the intracytoplasmic lumina. We also review the literature on bilaterally multifocal oncocytomas.
