A Heterogeneous Information Network Model for Long Non-Coding RNA Function Prediction.

Exciting information on the functional roles played by long non-coding RNA (lncRNA) has drawn substantial research attention these days. With the advent of techniques such as RNA-Seq, thousands of lncRNAs are identified in very short time spans. However, due to the poor annotation rate, only a few of them are functionally characterised. The wet lab experiments to elucidate lncRNA functions are challenging, slow progressing and sometimes prohibitively expensive. This work attempts to solve the crucial problem of developing computational methods to predict lncRNA functions. The model presented here, predicts the functions of lncRNAs by making use of a meta-path based measure, AvgSim on a Heterogeneous Information Network (HIN). The network is constructed from existing protein and function association data of lncRNAs, lncRNA co-expression data and protein protein interaction data. Out of the 2,758 lncRNA considered for the experiment, the proposed method predicts possible functions for 2,695 lncRNAs with an accuracy of 73.68 percent and found to perform better than the other state-of-the-art approaches for an independent test set. A case study of two well-known lncRNAs (HOTAIR and H19) is conducted and the associated functions are identified. The results were validated using experimental evidence from the literature. The script and data used for the implementation of the model is freely available at: http://bdbl.nitc.ac.in/LncFunPred/index.html.

Multidisciplinary Management of Chronic Atypical Facial Pain of Psychogenic Origin: A Unique Case Report.

AIM: The following case report discusses the diagnostic dilemma presented by and the multidisciplinary management of a patient with chronic atypical facial pain of psychogenic origin. BACKGROUND: Though oral health care professionals are primarily concerned with the treatment of somatic disorders of the orofacial region, there remains a particularly challenging need to identify, diagnose and treat various psychological and psychosomatic symptoms. CASE DESCRIPTION: This case report describes the management of a 13-year-old male patient with the chief complaint of pain and discoloration of the skin over the right side of the face for the last 5 months, who also demonstrated symptoms of chronic anxiety and social withdrawal. As no associated soft or hard tissue abnormalities could be identified, a diagnosis of atypical/psychogenic facial pain was established. The skin discoloration was diagnosed as pityriasis versicolor and treatment for the same commenced. Following the complete resolution of the skin lesion the patient was asymptomatic, and no longer anxious. CONCLUSION: Our role as dentists is to mitigate the suffering of patients and to improve their quality of life in collaboration with specialists in psychosomatic medicine. CLINICAL SIGNIFICANCE: This case highlights that dentists must be trained to treat not only teeth, but also attend to patient's psychosomatic symptoms. HOW TO CITE THIS ARTICLE: Naidu J, Bhattacharya P, Mendonsa JP, et al. Multidisciplinary Management of Chronic Atypical Facial Pain of Psychogenic Origin: A Unique Case Report. Int J Clin Pediatr Dent 2020;13(2):196-198.

Delay-induced synchrony in complex networks with conjugate coupling.

We demonstrate stable synchronous chaos in a delay coupled network of time continuous dynamical system using the framework of master stability formalism (MSF). It is further shown that conjugate coupling, i.e., coupling using dissimilar variables, can substitute delay coupling of similar variables in retrieving delay-induced phenomena. By exploiting the MSF, we show that delayed conjugate coupling in an arbitrary network is capable of both inducing synchronization where there is no synchronization at all and enhancing synchronization to a large parameter space, which even the conjugate coupling without delay is incapable of. The above results are demonstrated using the paradigmatic Rössler system and Hindmarsh-Rose neuron.

Noise-enhanced phase synchronization in time-delayed systems.

We investigate the phenomenon of noise-enhanced phase synchronization (PS) in coupled time-delay systems, which usually exhibit non-phase-coherent attractors with complex topological properties. As a delay system is essentially an infinite dimensional in nature with multiple characteristic time scales, it is interesting and crucial to understand the interplay of noise and the time scales in achieving PS. In unidirectionally coupled systems, the response system adjust all its time scales to that of the drive, whereas both subsystems adjust their rhythms to a single (main time scale of the uncoupled system) time scale in bidirectionally coupled systems. We find similar effects for both a common and an independent additive Gaussian noise.