Subject(s)
Acro-Osteolysis/epidemiology , Carpal Tunnel Syndrome/epidemiology , Fingers , Skin Ulcer/epidemiology , Aged , Aged, 80 and over , Comorbidity , Disease Progression , Female , Humans , MaleABSTRACT
Extramammary Paget disease is a rare condition that most commonly affects the anogenital region in the elderly. The treatment of choice has been surgical excision of the affected area with adequate depth and lateral margins, criteria that cannot always be fulfilled, especially when the vulva, anal canal, or penis are involved. More recently radiotherapy has been suggested as a suitable treatment when surgical excision or other modalities are not appropriate. We report a case of anogenital extramammary Paget disease and the clinical response to treatment with radiotherapy. The aim of this article is to review relevant aspects of radiotherapy as a first-choice curative treatment in specific situations of anogenital extramammary Paget disease in situ.
Subject(s)
Paget Disease, Extramammary/pathology , Paget Disease, Extramammary/radiotherapy , Skin Neoplasms/pathology , Skin Neoplasms/radiotherapy , Aged , Biopsy, Needle , Female , Follow-Up Studies , Humans , Immunohistochemistry , Neoplasm Staging , Paget Disease, Extramammary/diagnosis , Perineum/pathology , Radiotherapy Dosage , Rare Diseases , Risk Assessment , Skin Neoplasms/diagnosis , Treatment Outcome , Vulva/pathologyABSTRACT
Cobb syndrome is a rare non-inherited neurocutaneous disease, in which there are metameric cutaneous and spinal vascular malformations of the trunk. In cases of segmentally distributed multiple cutaneous vascular lesions, early diagnostic imaging of the spinal cord allows prompt intervention in order to reduce permanent neurological sequelae. We report case of Cobb syndrome in a 12-year-old boy and present a systematic review of the literature.
Subject(s)
Neurocutaneous Syndromes/diagnosis , Skin Diseases, Vascular/diagnosis , Spine/blood supply , Arteriovenous Malformations/diagnostic imaging , Central Nervous System Vascular Malformations/diagnostic imaging , Child , Humans , Male , Neurocutaneous Syndromes/diagnostic imaging , Radiography , Skin Diseases, Vascular/diagnostic imaging , Spine/diagnostic imagingABSTRACT
Tacalcitol is a vitamin D analog with proven efficacy for the topical treatment of psoriasis, but to date it has not been tested in psoriasis of the nail. However, successful treatment has been reported with other vitamin D derivatives such as topical calcipotriol, and topical calcitriol in one study. The present study aimed to assess the efficacy and tolerability of topical tacalcitol in the treatment of nail psoriasis in a sample of 15 patients over a 6-month period. Treatment with tacalcitol ointment may be useful to treat nail psoriasis as it achieves a significant improvement in all nail parameters, both of the matrix and of the bed.
