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1.
Expert Rev Anti Infect Ther ; 19(11): 1385-1396, 2021 11.
Article in English | MEDLINE | ID: mdl-33852807

ABSTRACT

Introduction: The coronavirus disease-2019 (COVID-19) is a highly contagious respiratory viral disease for both the general population and healthcare professionals caring for infected patients. Of particular concern is the potential for significant respiratory, cardiovascular, physical, and psychological dysfunctions.Areas covered: In this context, the current review will focus on the following areas: 1) staying physically active during the COVID-19 pandemic; 2) highlighting the importance of understanding COVID-19 mechanisms; 3) preventing infections for healthcare workers by using personal protective equipment; 4) highlighting importance of respiratory care and physical therapy during hospitalization in patients with COVID-19; and 5) facilitating referral to a rehabilitation program in patients recovering from COVID-19.Expert opinion: We recommend daily physical exercise, outdoors or at home, as physical exercise increases the synthesis of anti-inflammatory cytokines; Patients with COVID-19 may develop severe acute respiratory syndrome, hypoxemia, diffuse alveolar damage, ACE2 reduction in the cardiovascular system and muscle weakness acquired through a prolonged hospital stay; The role of the physiotherapist in the hospital environment is of fundamental importance-early mobilization is highly recommended in severe cases of COVID-19.


Subject(s)
COVID-19 , Exercise Therapy , Life Style , Pandemics , Rehabilitation/organization & administration , Exercise , Health Personnel , Humans
2.
Rev. Soc. Cardiol. Estado de Säo Paulo ; 28(3 (supl)): 342-344, jul.-set. 2018.
Article in English, Portuguese | LILACS, Sec. Est. Saúde SP, SESSP-IDPCPROD, Sec. Est. Saúde SP | ID: biblio-964362

ABSTRACT

Em diversas situações de emergência cardiológica, a tomada de decisão rápida a beira leito deve estar bem fundamentada para melhor eficácia terapêutica e baseada no conhecimento fisiológico e fisiopatológico da disfunção cardíaca que associada com a adequada monitorização hemodinâmica do paciente possibilitam indicar ou contraindicar o uso da ventilação mecânica invasiva e não-invasiva. Portanto, o presente artigo de opinião reitera alguns aspectos hemodinâmicos a serem lembrados e aplicados no dia a dia do fisioterapeuta


In various cardiac emergency situations, rapid decision-making at the patient's bedside should be well-founded, to ensure better therapeutic efficacy that is based on a physiological and pathophysiological knowledge of the cardiac dysfunction and adequate hemodynamic monitoring of the patient, enabling the indication or non-indication of invasive/non-invasive mechanical ventilation. This opinion article therefore reiterates some hemodynamic aspects to be remembered and applied in the physical therapist's daily routine


Subject(s)
Humans , Male , Female , Exercise , Cardiac Rehabilitation/methods , Myocardial Infarction/parasitology , Patient Discharge , Patients , Risk Factors , Guidelines as Topic/standards , Exercise Test/methods , Heart Rate , Medical History Taking/methods , Myocardial Revascularization
3.
Arq. bras. cardiol ; 110(5): 467-475, May 2018. tab, graf
Article in English | LILACS, Sec. Est. Saúde SP, SESSP-IDPCPROD, Sec. Est. Saúde SP | ID: biblio-950151

ABSTRACT

Abstract Background: Exercise training (ET) improves functional capacity in chronic heart failure (HF). However, ET effects in acute HF are unknown. Objective: To investigate the effects of ET alone or combined with noninvasive ventilation (NIV) compared with standard medical treatment during hospitalization in acute HF patients. Methods: Twenty-nine patients (systolic HF) were randomized into three groups: control (Control - only standard medical treatment); ET with placebo NIV (ET+Sham) and ET+NIV (NIV with 14 and 8 cmH2O of inspiratory and expiratory pressure, respectively). The 6MWT was performed on day 1 and day 10 of hospitalization and the ET was performed on an unloaded cycle ergometer until patients' tolerance limit (20 min or less) for eight consecutive days. For all analyses, statistical significance was set at 5% (p < 0.05). Results: None of the patients in either exercise groups had adverse events or required exercise interruption. The 6MWT distance was greater in ET+NIV (Δ120 ± 72 m) than in ET+Sham (Δ73 ± 26 m) and Control (Δ45 ± 32 m; p < 0.05). Total exercise time was greater (128 ± 10 vs. 92 ± 8 min; p < 0.05) and dyspnea was lower (3 ± 1 vs. 4 ± 1; p < 0.05) in ET+NIV than ET+Sham. The ET+NIV group had a shorter hospital stay (17 ± 10 days) than ET+Sham (23 ± 8 days) and Control (39 ± 15 days) groups (p < 0.05). Total exercise time in ET+Sham and ET+NIV had significant correlation with length of hospital stay (r = -0.75; p = 0.01). Conclusion: Exercise training in acute HF was safe, had no adverse events and, when combined with NIV, improved 6MWT and reduce dyspnea and length of stay.


Resumo Fundamento: O exercício físico melhora a capacidade funcional em pacientes com insuficiência cardíaca (IC) crônica. Entretanto, os efeitos do exercício na IC aguda são desconhecidos. Objetivo: Investigar os efeitos do exercício físico isolado ou associado à ventilação não-invasiva (VNI) em comparação ao tratamento convencional em pacientes com IC durante internação. Métodos: Vinte e nove pacientes (IC sistólica) foram randomizados em três grupos: Controle (tratamento clínico convencional); exercício com ventilação placebo (EX+Sham) e EX+VNI (VNI com 14 e 8 cmH2O de pressão inspiratória e expiratória, respectivamente).O TC6M foi realizado no primeiro e no décimo dia de internação e o exercício realizado em cicloergômetro até o limite de tolerância (20 minutos ou menos) por oito dias consecutivos. Para todas as análises, foi considerado p < 0,05 estatisticamente significante. Resultados: Nenhum paciente dos grupos EX+Sham e EX+VNI apresentou complicações ou necessitou interromper o exercício. O grupo EX+VNI apresentou melhor desempenho no TC6M (Δ120 ± 72 m) que os grupos EX+Sham (Δ73 ± 26 m) e Controle (Δ45 ± 32 m; p < 0,05). O tempo total de exercício foi maior (128 ± 10 vs. 92 ± 8 min; p < 0,05) e a dispneia menor (3 ± 1 vs. 4 ± 1; p < 0,05) no EX+VNI em relação ao EX+Sham. O grupo EX+VNI apresentou menor tempo de internação (17 ± 10 dias) comparado ao EX+Sham (23 ± 8 dias) e Controle (39 ± 15 dias; p < 0,05). O tempo total de exercício nos grupos EX+Sham e EX+VNI correlacionou-se com o tempo de internação hospitalar (r = -0,75; p = 0,01). Conclusão: O exercício físico foi seguro em pacientes com IC aguda, não houve complicações hospitalares e, quando associada à VNI, melhorou o desempenho no TC6M, dispneia e o tempo de internação.


Subject(s)
Humans , Male , Female , Middle Aged , Exercise Tolerance , Exercise Therapy/methods , Noninvasive Ventilation , Heart Failure/rehabilitation , Acute Disease , Prospective Studies , Treatment Outcome , Length of Stay
4.
Arq Bras Cardiol ; 110(5): 467-475, 2018 May.
Article in English, Portuguese | MEDLINE | ID: mdl-29538506

ABSTRACT

BACKGROUND: Exercise training (ET) improves functional capacity in chronic heart failure (HF). However, ET effects in acute HF are unknown. OBJECTIVE: To investigate the effects of ET alone or combined with noninvasive ventilation (NIV) compared with standard medical treatment during hospitalization in acute HF patients. METHODS: Twenty-nine patients (systolic HF) were randomized into three groups: control (Control - only standard medical treatment); ET with placebo NIV (ET+Sham) and ET+NIV (NIV with 14 and 8 cmH2O of inspiratory and expiratory pressure, respectively). The 6MWT was performed on day 1 and day 10 of hospitalization and the ET was performed on an unloaded cycle ergometer until patients' tolerance limit (20 min or less) for eight consecutive days. For all analyses, statistical significance was set at 5% (p < 0.05). RESULTS: None of the patients in either exercise groups had adverse events or required exercise interruption. The 6MWT distance was greater in ET+NIV (Δ120 ± 72 m) than in ET+Sham (Δ73 ± 26 m) and Control (Δ45 ± 32 m; p < 0.05). Total exercise time was greater (128 ± 10 vs. 92 ± 8 min; p < 0.05) and dyspnea was lower (3 ± 1 vs. 4 ± 1; p < 0.05) in ET+NIV than ET+Sham. The ET+NIV group had a shorter hospital stay (17 ± 10 days) than ET+Sham (23 ± 8 days) and Control (39 ± 15 days) groups (p < 0.05). Total exercise time in ET+Sham and ET+NIV had significant correlation with length of hospital stay (r = -0.75; p = 0.01). CONCLUSION: Exercise training in acute HF was safe, had no adverse events and, when combined with NIV, improved 6MWT and reduce dyspnea and length of stay.


Subject(s)
Exercise Therapy/methods , Exercise Tolerance , Heart Failure/rehabilitation , Noninvasive Ventilation , Acute Disease , Female , Humans , Length of Stay , Male , Middle Aged , Prospective Studies , Treatment Outcome
5.
P R Health Sci J ; 37(1): 39-45, 2018 03.
Article in English | MEDLINE | ID: mdl-29547683

ABSTRACT

OBJECTIVE: Colorectal cancer (CRC) is a leading causes of cancer death among men and women. The purpose of this study was to determine the prevalence of oligopolyposis (≥20 synchronous colorectal adenomas) and its associated clinicopathological characteristics in Hispanics with incident CRC. METHODS: Pathology reports from individuals diagnosed with CRC (2007 to 2011) were obtained from the PR Central Cancer Registry. Colorectal polyp burden was calculated using pathology reports and the data was normalized to colon segment size. Comparisons of demographic and clinicopathological characteristics by synchronous oligopolyposis status (<20 vs. <= *20) were performed using the chi-square or Fisher's exact test. Multivariate logistic regression models were fitted to estimate the adjusted prevalence odds ratios (aPOR), with 95% confidence intervals (CI). All analyses were performed using Stata (v.12.0). RESULTS: Analyses of 1,573 colectomy specimens was performed. Oligopolyposis was observed in 9.47% (149 of 1,573) of the subjects with incident CRC. Increasing age (aPOR50-64 = 1.72, 95% CI: 0.59-5.02; aPOR65-74 = 1.83, 95% CI: 0.64-5.27; aPOR≥75 = 2.67, 95% CI: 0.93-7.64) and proximal CRC tumor location (POR = 2.91, 95% CI:1.98-4.30) were significantly associated with having oligopolyposis at CRC diagnosis. However, subjects diagnosed with CRC at a regional stage (aPORRegional = 0.50, 95% CI: 0.32-0.79) or distant stage (aPORDistant = 0.45, 95% CI: 0.29-0.69) were less likely to have synchronous oligopolyposis (p<0.05). CONCLUSION: Our findings suggest that genetic syndromes associated with colorectal polyposis may be implicated in a higher than expected number of CRC cases. Individuals with CRC and synchronous oligopolyposis should receive genetic counseling.


Subject(s)
Adenomatous Polyposis Coli/epidemiology , Colorectal Neoplasms/epidemiology , Neoplasms, Multiple Primary/epidemiology , Aged , Female , Humans , Male , Middle Aged , Prevalence , Retrospective Studies
6.
Ann Intensive Care ; 7(1): 95, 2017 Sep 08.
Article in English | MEDLINE | ID: mdl-28887766

ABSTRACT

BACKGROUND: Active mobilization is not possible in patients under deep sedation and unable to follow commands. In this scenario, passive therapy is an interesting alternative. However, in patients with septic shock, passive mobilization may have risks related to increased oxygen consumption. Our objective was to evaluate the impact of passive mobilization on sublingual microcirculation and systemic hemodynamics in patients with septic shock. METHODS: We included patients who were older than 18 years, who presented with septic shock, and who were under sedation and mechanical ventilation. Passive exercise was applied for 20 min with 30 repetitions per minute. Systemic hemodynamic and microcirculatory variables were compared before (T0) and up to 10 min after (T1) passive exercise. p values <0.05 were considered significant. RESULTS: We included 35 patients (median age [IQR 25-75%]: 68 [49.0-78.0] years; mean (±SD) Simplified Acute Physiologic Score (SAPS) 3 score: 66.7 ± 12.1; median [IQR 25-75%] Sequential Organ Failure Assessment (SOFA) score: 9 [7.0-12.0]). After passive mobilization, there was a slight but significant increase in proportion of perfused vessels (PPV) (T0 [IQR 25-75%]: 78.2 [70.9-81.9%]; T1 [IQR 25-75%]: 80.0 [75.2-85.1] %; p = 0.029), without any change in other microcirculatory variables. There was a reduction in heart rate (HR) (T0 (mean ± SD): 95.6 ± 22.0 bpm; T1 (mean ± SD): 93.8 ± 22.0 bpm; p < 0.040) and body temperature (T0 (mean ± SD): 36.9 ± 1.1 °C; T1 (mean ± SD): 36.7 ± 1.2 °C; p < 0.002) with no change in other systemic hemodynamic variables. There was no significant correlation between PPV variation and HR (r = -0.010, p = 0.955), cardiac index (r = 0.218, p = 0.215) or mean arterial pressure (r = 0.276, p = 0.109) variation. CONCLUSIONS: In patients with septic shock after the initial phase of hemodynamic resuscitation, passive exercise is not associated with relevant changes in sublingual microcirculation or systemic hemodynamics.

7.
Arch Physiother ; 7(2): 1-5, Jan. 2017. graf, tab
Article in English | Sec. Est. Saúde SP, SESSP-IDPCPROD, Sec. Est. Saúde SP | ID: biblio-1290894

ABSTRACT

BACKGROUND: Cardiac surgery is widely used in the treatment of cardiovascular diseases. However, several complications can be observed during the postoperative period. Positive end expiratory pressure (PEEP) improves gas exchange, but it might be related to decreased cardiac output and possible impairment of tissue oxygenation. The aim of this study was to investigate the hemodynamic effects and oxygen saturation of central venous blood (ScvO2) after increasing PEEP in hypoxemic patients after coronary artery bypass (CAB) surgery. METHODS: Seventy post-cardiac surgery patients (CAB), 61 ± 7 years, without ventricular dysfunction (left ventricular ejection fraction 57 ± 2%), with hypoxemia (PaO2/FiO2 ratio <200) were enrolled. Heart rate, mean arterial pressure, arterial and venous blood samples were measured at intensive care unit and PEEP was increased to 12 cmH2O for 30min. RESULTS: As expected, PEEP12 improved arterial oxygenation and PaO2/FiO2 ratio (p < 0.0001). Reduction in ScvO2 was observed between PEEP5 (63 ± 2%) and PEEP12 (57 ± 1%; p = 0.01) with higher values of blood lactate in PEEP12 (p < 0.01). No hemodynamic effects (heart rate, mean arterial pressure, SpO2; p > 0.05) were related. CONCLUSION: Increased PEEP after cardiac surgery decreased ScvO2 and increased blood lactate, even with higher O2 delivery. PEEP did not interfere in hemodynamics status in CAB patients, suggesting that peripheral parameters must be controlled and measured during procedures involving increased PEEP in post-cardiac surgery patients in the intensive care unit.


Subject(s)
Thoracic Surgery , Positive-Pressure Respiration , Hemodynamics , Oxygenation , Physical Therapy Specialty
8.
Arch Physiother ; 7: 2, 2017.
Article in English | MEDLINE | ID: mdl-29340197

ABSTRACT

BACKGROUND: Cardiac surgery is widely used in the treatment of cardiovascular diseases. However, several complications can be observed during the postoperative period. Positive end expiratory pressure (PEEP) improves gas exchange, but it might be related to decreased cardiac output and possible impairment of tissue oxygenation. The aim of this study was to investigate the hemodynamic effects and oxygen saturation of central venous blood (ScvO2) after increasing PEEP in hypoxemic patients after coronary artery bypass (CAB) surgery. METHODS: Seventy post-cardiac surgery patients (CAB), 61 ± 7 years, without ventricular dysfunction (left ventricular ejection fraction 57 ± 2%), with hypoxemia (PaO2/FiO2 ratio <200) were enrolled. Heart rate, mean arterial pressure, arterial and venous blood samples were measured at intensive care unit and PEEP was increased to 12 cmH2O for 30 min. RESULTS: As expected, PEEP12 improved arterial oxygenation and PaO2/FiO2 ratio (p < 0.0001). Reduction in ScvO2 was observed between PEEP5 (63 ± 2%) and PEEP12 (57 ± 1%; p = 0.01) with higher values of blood lactate in PEEP12 (p < 0.01). No hemodynamic effects (heart rate, mean arterial pressure, SpO2; p > 0.05) were related. CONCLUSION: Increased PEEP after cardiac surgery decreased ScvO2 and increased blood lactate, even with higher O2 delivery. PEEP did not interfere in hemodynamics status in CAB patients, suggesting that peripheral parameters must be controlled and measured during procedures involving increased PEEP in post-cardiac surgery patients in the intensive care unit.

9.
J Cardiothorac Vasc Anesth ; 30(3): 702-8, 2016 Jun.
Article in English | MEDLINE | ID: mdl-26725406

ABSTRACT

OBJECTIVE: To compare pulmonary function, functional capacity, and clinical outcomes among conventional mechanical ventilation (CMV), early open-lung (EOL), and late open-lung (LOL) strategies after off-pump coronary artery bypass surgery (OPCAB). DESIGN: Prospective, randomized, and double-blinded study. SETTING: Two hospitals of the Federal University of Sao Paulo, Brazil. PARTICIPANTS: Ninety-three patients undergoing elective first-time OPCAB. INTERVENTIONS: Patients were randomized into 3 groups: CMV (n=31); LOL (n=32) initiated upon intensive care unit (ICU) arrival; EOL (n = 30) initiated after intubation. MEASURAMENTS AND MAIN RESULTS: Spirometry was performed at bedside preoperatively and on postoperative days (PODs) 1, 3, and 5. Partial pressure of arterial oxygen (PaO2) and pulmonary shunt fraction were evaluated presurgically and on POD 1; 6-minute walk test (6MWT) was performed presurgically and on POD 5. Both open-lung groups demonstrated higher forced vital capacity and forced expiratory volume in 1 second on PODs 1, 3 and 5 compared to the CMV group (p<0.05). Similar results were found in relation to the 6MWT distance. Shunt fraction was lower and PaO2 was higher in both open-lung groups (p<0.05). Open-lung groups had shorter intubation time and hospital stay as well as fewer respiratory events (p<0.05). No statistical difference was found relative to the aforementioned results when the EOL and LOL groups were compared. CONCLUSIONS: Both open-lung strategies were able to promote higher pulmonary function preservation and greater recovery of functional capacity with better clinical outcomes after OPCAB. No difference in outcome was found when comparing initiation of OLS intraoperatively or after ICU arrival.


Subject(s)
Coronary Artery Bypass, Off-Pump/methods , Respiration, Artificial , Adult , Aged , Double-Blind Method , Female , Forced Expiratory Volume , Humans , Male , Middle Aged , Oxygen/blood , Positive-Pressure Respiration , Prospective Studies , Vital Capacity
10.
ACG Case Rep J ; 1(4): 184-6, 2014 Jul.
Article in English | MEDLINE | ID: mdl-26157870

ABSTRACT

A 31-year-old woman was diagnosed with duodenal grade 1 follicular lymphoma. The patient underwent radiotherapy and on surveillance enteroscopy, the lymphoma was persistently identified in the duodenum and jejunum. Endoscopic clips were used as fiducials to better localize the tumor during radiotherapy. Endoscopic clips are increasingly used as tumor localization tools because of their favorable risk-benefit ratio. In our case, endoscopic clipping was necessary to properly localize the tumor after prior treatment failure, and the patient now has no evidence of disease. Larger studies are needed to demonstrate the efficacy of clips in tumor localization and improved disease-related morbidity.

11.
In. Umeda, Iracema Ioco Kikuchi. Manual de fisioterapia na reabilitação cardiovascular. Barueri, Manole, 20140000. p.55-92, ilus, graf, tab.
Monography in Portuguese | Sec. Est. Saúde SP, SESSP-IDPCPROD, Sec. Est. Saúde SP | ID: biblio-1080216
12.
In. Umeda, Iracema Ioco Kikuchi. Manual de fisioterapia na reabilitação cardiovascular. Barueri, Manole, 20140000. p.93-135, ilus, tab.
Monography in Portuguese | Sec. Est. Saúde SP, SESSP-IDPCPROD, Sec. Est. Saúde SP | ID: biblio-1080217
13.
In. Umeda, Iracema Ioco Kikuchi. Manual de fisioterapia na reabilitação cardiovascular. Barueri, Manole, 20140000. p.169-194, ilus, tab.
Monography in Portuguese | Sec. Est. Saúde SP, SESSP-IDPCPROD, Sec. Est. Saúde SP | ID: biblio-1080219
14.
Rev. Soc. Cardiol. Estado de Säo Paulo ; 23(3,supl.A): 34-37, jul.-set. 2013.
Article in Portuguese | LILACS | ID: lil-767464

ABSTRACT

Introdução: A ventilação mecânica (VM) é indispensável nas intervençõescirúrgicas cardíacas. Porém, mesmo que por curto períodode tempo, pode causar prejuízo pulmonar, com lesões no parênquimapor excesso de pressão e/ou volume nas vias aéreas. Na titulação dovolume corrente (VC), é comum utilizar o peso real e não o pesoideal, aquele calculado baseando-se pela altura, o que poderia geraralterações gasométricas e na mecânica pulmonar. Objetivo: Comparara titulação do volume corrente pelo peso ideal e pelo peso realdurante o uso da VM no pós-operatório imediato de cirurgia cardíaca.Método: Ensaio clínico prospectivo, randomizado, realizado no períodode agosto a novembro de 2008. Pacientes de ambos os gêneros,idade entre 18 e 80 anos foram randomizados em dois grupos: peso real(PR) e peso ideal (PI) durante o pós-operatório imediato de cirurgiacardíaca, nos quais foram analisados a troca gasosa, pela gasometriarealizada no ato de admissão e 30 minutos após a mesma; e a mecânicapulmonar (pressão platô). Pacientes com acidose metabólicacom pH < 7,2 foram excluídos. A análise estatística incluiu teste denormalidade de Kolmogorov-Smirnov, teste t com p < 0,05, e testede Mann Whitney para variáveis não paramétricas. Resultados: Totalde 55 pacientes, sendo 28 no grupo PR e 25 no PI; dois pacientesexcluídos, restando 29 homens e 24 mulheres. A idade média foi de58,83 ± 11,74 anos. Os valores de pressão platô (PR: 19,29 cmH2Ovs PI: 17,12 cmH2O), pH (PR: 7,38 vs. PI: 7,32) e PCO2 (PR: 34,5mmHg vs. PI: 40,85 mmHg) foram estatisticamente significantes,com p < 0,04, p < 0,01 e p < 0,02, respectivamente. Conclusão: Usodo PR pareceu ser benéfico na população estudada quando analisadodistúrbio ácido básico; porém, o grupo PI mostrou-se melhor quantoà mecânica pulmonar.


Introduction: The mechanical ventilation (MV) is essential in cardiacsurgery. But even for a short period of time, the MV can causelung injury with parenchyma injury of pressure and/or volume inthe airways. In the titration of tidal it is common to use the actualweight rather than the ideal weight, calculated based on the height,which could generate gasometric and changes in lung mechanics.Objective: To compare the titration of the current volume by idealweight and the actual weight during the use of MV in the immediatepostoperative period of cardiac surgery. Method: Clinical prospective,randomized, carried out from August to November 2008. Patientsof both sexes, aged between 18 and 80 years, randomized into twogroups: actual weight (AW) and ideal weight (IW), in the immediatepostoperative period of cardiac surgery. The blood gas analysis wasconducted in the act of admission and 30 minutes after that. Blood gasand pressure plateau results were compared among the two groups.Patients with metabolic acidosis of pH < 7.2 were excluded. Statisticalanalysis included the test of Kolmogorov-Smirnov normality, t testwith p < 0.05, and the Mann Whitney test for non parametric variables.Results: Total 55 patients being 28 PR and 25 IP, 2 excludedpatients, 29 men and 24 women. The average age was 58.83 ± 11.74years. The values of Plateau pressure (real: 19.29 vs ideal: 17.12), pH(real: 7.38 vs ideal: 7.32) and PCO2 (real: 34.5 vs ideal: 40.85) werestatistically significant, with p < 0.04, p < 0.01 and p < 0.02, respectively.Conclusion: Using the actual weight seemed to be beneficialin the study population as compared to the ideal weight when disturbacid basic was analyzed.


Subject(s)
Humans , Male , Female , Middle Aged , Thoracic Surgery/trends , Postoperative Care/rehabilitation , Respiration, Artificial/adverse effects , Pragmatic Clinical Trial , Body Weight/physiology
15.
Fam Cancer ; 12(3): 555-62, 2013 Sep.
Article in English | MEDLINE | ID: mdl-23460355

ABSTRACT

Several genetically defined hereditary colorectal cancer (CRC) syndromes are associated with colonic polyposis including familial adenomatous polyposis (FAP) and MUTYH adenomatous polyposis (MAP). Limited data exists on the clinical characterization and genotypic spectrum of polyposis syndromes among Hispanics. To describe the phenotype and genotype of Puerto Rican Hispanic patients with FAP and MUTYH and compare with other ethnic and racial groups. Probands were identified from the Puerto Rico Familial Colorectal Cancer Registry (PURIFICAR). Recruited individuals completed risk factors, medical, and family history questionnaires and underwent genetic testing for genotype analysis. Frequency analysis, Chi square, Fisher's exact and Wilcoxon rank-sum tests were used for statistical analysis methods. A total of 31 FAP (from 19 families) and 13 MAP (from 13 families) Hispanic patients recruited from the PURIFICAR were evaluated. Among the FAP cases, mean age at diagnosis was 27.6 (range 9-71 years); 67.7 % cases had more than 100 polyps and 41.9 % had upper gastrointestinal polyps. Among the 19 FAP families, there were 77 affected FAP individuals and 26 colorectal cancer cases. Genetic mutations were available for 42.2 % of FAP families; all mutations identified were unique. Surgeries were reported in 31 cases; 14 (45.2 %) prophylactic surgeries and 6 (19.4 %) therapeutic surgeries for management of CRC. Among MAP cases, mean age at diagnosis was 53 (range 34-76 years). Genetic analysis revealed homozygous biallelic mutations (G382D) in 53.8 %, compound heterozygous mutations (G382/Y165C) in 23 %, and non-G382/Y165C monoallelic mutations in 23 %. Familial cancer registries should be promoted as vehicles for detection, education and follow up of families at-risk of acquiring familial cancers. PURIFICAR is the first and only familial cancer registry in Puerto Rico providing these services to families affected with familial cancer syndromes promoting education, testing and surveillance of at-risk family members, and focusing on cancer prevention efforts. The fact that only 40 % of FAP patients had access to genetic testing stresses the need to promote the establishment of policies supporting genetic testing coverage by medical insurance companies in order to provide patients with the highest standard of care to prevent cancer. Furthermore, our results suggest that Hispanics may have uncommon mutations in adenomatous polyposis related genes, which emphasize the need for full gene sequencing to establish genetic diagnosis.


Subject(s)
Adenomatous Polyposis Coli/ethnology , Adenomatous Polyposis Coli/genetics , DNA Glycosylases/genetics , Genetic Testing , Hispanic or Latino/genetics , Mutation/genetics , Adenomatous Polyposis Coli/classification , Adenomatous Polyposis Coli/diagnosis , Adolescent , Adult , Aged , Child , Family , Female , Follow-Up Studies , Genetic Predisposition to Disease , Genotype , Humans , Male , Middle Aged , Phenotype , Prognosis , Puerto Rico , Syndrome , Young Adult
16.
In. Sousa, Amanda Guerra de Moraes Rego; Umeda, Iracema Ioco Kikuchi; Méndez, Vanessa Marques Ferreira. Fisioterapia. São Paulo, Atheneu, 2013. p.34-121, ilus, tab, graf.
Monography in Portuguese | Sec. Est. Saúde SP, SESSP-IDPCPROD, Sec. Est. Saúde SP | ID: biblio-1079789
17.
In. Sousa, Amanda Guerra de Moraes Rego; Magnoni, Daniel; Germini, Michele Fernanda Canfild Antunes. Fonoaudiologia. São Paulo, Atheneu, 2013. p.52-79, tab.
Monography in Portuguese | Sec. Est. Saúde SP, SESSP-IDPCPROD, Sec. Est. Saúde SP | ID: biblio-1079809
18.
Lima; s.n; 2013. 79 p. tab, graf.
Thesis in Spanish | LIPECS | ID: biblio-1113064

ABSTRACT

El estudio titulado "Conocimientos sobre la Hipertensión Arterial y sus Medidas Preventivas en una Población de Choferes de la Empresa de Transportes y Servicios Expreso Santa Anita. 2012" se ha realizado en la Cuidad de Lima, entendiendo que la Hipertensión Arterial es una enfermedad crónica no transmisible que junto con el cáncer, enfermedades respiratorias crónicas y la diabetes, forman parte de una de las Estrategias Sanitarias Nacionales, constituyendo la mayor causa de muerte y de discapacidad en muchos de los países de las Américas, resultando gran impacto sanitario y económico. Representa por sí misma una enfermedad, como también un factor de riesgo importante para otras enfermedades, fundamentalmente para la Cardiopatía Isquémica, Insuficiencia Cardíaca, Enfermedad Cerebro Vascular, Insuficiencia Renal y contribuye significativamente a la Retinopatía. En nuestro País afecta a una de cada cuatro personas por lo que se hace indispensable la educación a la población, por ello la importancia del rol del Enfermero(a) en la promoción de la Salud y prevención de la enfermedad, fomentando estilos de vida saludables y generando entornos laborales saludables como parte de las medidas preventivas para disminuir el riesgo de enfermar y así mismo contribuir en el mejoramiento de las condiciones de salud y productividad laboral de la población. El objetivo del presente trabajo fue determinar los conocimientos sobre Hipertensión arterial y sus medidas preventivas en los choferes que laboran en la Empresa de Transportes y Servicios Expreso Santa Anita S.A., con el propósito incentivar el liderazgo del Profesional de Enfermería en los Programas de Promoción de la Salud en los centros laborales, de tal forma que beneficien el autocuidado y desarrollo integral del trabajador y que la gerencia de transportes coordine con el centro de salud más cercano acciones que fomenten la salud de sus trabajadores disminuyendo sus factores de riesgo. El estudio es de tipo...


In the study entitled "Knowledge Hypertension and Preventive Measures in a Population of Drivers Transport Company and Express Services Santa Anita, 2012" was conducted in the City of Lima, understanding that hypertension is a chronic non communicable with cancer, chronic respiratory diseases and diabetes, are part of a National Hea1th Strategies, constituting the leading cause of death and disability in most countries of the Americas, also a major health and economic impact. Represents a disease itself, as well is also important risk factor for other diseases, mainly for coronary heart disease, heart failure, cerebrovascular disease and renal failure and contributes significantly to retinopathy. In our country affects one in four people so that education is essential to the population, hence the importance of the role of the Nurse in Health promotion and disease prevention, promoting healthy lifestyles and creating hea1thy work environments as part of preventive measures to reduce the risk of disease and likewise contribute to the improvement of health conditions and labor productivity of the population. The objective of this study was to determine the knowledge about hypertension and its preventive measures drivers working in the Transport and Services Company Express Santa Anita S.A., in order to encourage leadership of Professional Nursing Programs Promotion health in the workplace, so that self-care benefit and development of the worker and to develop transport management actions that promote the health of their workers by decreasing their risk factors. The study is a quantitative, application-level, cross-sectional descriptive method. The population consisted of 60 drivers ranging in age from 35 to 65, which concludes that the vast majority of drivers surveyed 98.3 per cent (59) know about high blood pressure, also 95 per cent (57) unknown preventive measures for hypertension and the importance of healthy eating, physical activity, the importance of...


Subject(s)
Humans , Automobile Driving , Hypertension/diagnosis , Hypertension/prevention & control , Transportation , Cross-Sectional Studies
20.
Photomed Laser Surg ; 27(3): 467-71, 2009 Jun.
Article in English | MEDLINE | ID: mdl-19405858

ABSTRACT

OBJECTIVE: The aim of this study was to evaluate the effectiveness of an interferential pattern generated by two identical and independent lasers in the relief of knee pain. BACKGROUND DATA: Low-level laser therapy (LLLT) is generally applied by a single probe. MATERIALS AND METHODS: A double-blind controlled clinical trial was performed on 152 patients with knee pain who were randomly assigned into two different groups. Group I patients (n = 76) received interferential laser therapy generated by two identical laser probes located opposite each other on the knee joint. Group II patients (n = 76) received one live probe in conventional laser therapy and one dummy probe. The device used in both groups was an AlGaAs laser (wavelength 810 nm, power 100 mW, in continuous mode). Fifteen laser sessions were applied transcutaneously on 5 knee points (6 J/point) per session. In addition, patients in both groups received a quadriceps strength program based on isometric exercises. A visual analogue scale (VAS) was used for pain evaluation in different situations, such as in standing, in knee flexion/extension, and when going up and down stairs. VAS pain scores were evaluated before, in the middle of, and after treatment. RESULTS: ANOVA results showed no significant differences between groups for all VAS scores or in the interaction with the sessions (p > 0.05). The VAS score results showed a statistically significant pain reduction throughout all sessions (p = 0.000). CONCLUSIONS: Interferential laser therapy is safe and effective in reducing knee pain. However, the results of the study indicate that it is not superior to the use of a single conventional laser.


Subject(s)
Knee , Low-Level Light Therapy , Pain/radiotherapy , Analysis of Variance , Double-Blind Method , Exercise Therapy , Female , Humans , Male , Middle Aged , Pain Measurement , Treatment Outcome
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