Incidence of COVID-19 in patients under chronic treatment with hydroxychloroquine.

OBJECTIVE: To analyze the incidence of Covid-19 in patients who are chronic users of hydroxychloroquine. PATIENTS AND METHODS: Cross-sectional retrospective observational multicenter study in health areas and districts from Castilla La-Mancha and Andalucia. Of the 4451 participants included in the first recruitment, 3817 with valid data were selected. The main variable of the study is the presence or absence of Covid-19 infection by clinical, serological or polymerase chain reaction diagnosis. Sociodemographic and clinical variables and treatment and concomitant comorbidities were recorded. RESULTS: 169 (4,45%) patients had Covid-19 infection, of which 12 (7.1 %) died and 32 (18.9%) required hospital admission. Previous respiratory pathology was related to Covid-19 infection (P < .05). Maculopathy appears in 5.3% of patients and is significantly related to the dose of hydroxychloroquine consumed (P < .05). CONCLUSION: There is no relationship between chronic use of hydroxychloroquine and the incidence of Covid-19.

OBJETIVO: Analizar la incidencia de la enfermedad del coronavirus 19 (COVID-19) en pacientes consumidores crónicos de hidroxicloroquina. PACIENTES Y MÉTODOS: Estudio multicéntrico observacional retrospectivo transversal en Áreas de Salud de Castilla La-Mancha y distritos sanitarios de Andalucía. De los 4.451 participantes incluidos en el primer reclutamiento se seleccionaron 3.817 sujetos con datos válidos. La variable principal del estudio ha sido la presencia o ausencia de infección por la COVID-19 por diagnóstico clínico, serológico o por reacción en cadena de la polimerasa. Se registraron variables sociodemográficas, clínicas y tratamientos y comorbilidades concomitantes. RESULTADOS: Ciento sesenta y nueve (4,45%) pacientes presentaron infección por la COVID-19, de los cuales fallecieron 12 (7,1%) y 32 (18,9%) requirieron ingreso hospitalario. La enfermedad respiratoria previa se relacionó con la infección por la COVID-19 (p < 0,05). La maculopatía aparece en un 5,3% de los pacientes y está relacionada significativamente con la dosis de hidroxicloroquina consumida (p < 0,05). CONCLUSIÓN: No existe relación entre consumo crónico de hidroxicloroquina e incidencia de la COVID-19.

Incidencia de la COVID-19 en pacientes en tratamiento crónico con hidroxicloroquina / Incidence of COVID-19 in patients under chronic treatment with hydroxychloroquine

Objetivo: Analizar la incidencia de la enfermedad del coronavirus 19 (COVID-19) en pacientes consumidores crónicos de hidroxicloroquina.Pacientes y métodosEstudio multicéntrico observacional retrospectivo transversal en Áreas de Salud de Castilla La-Mancha y distritos sanitarios de Andalucía. De los 4.451 participantes incluidos en el primer reclutamiento se seleccionaron 3.817 sujetos con datos válidos. La variable principal del estudio ha sido la presencia o ausencia de infección por la COVID-19 por diagnóstico clínico, serológico o por reacción en cadena de la polimerasa. Se registraron variables sociodemográficas, clínicas y tratamientos y comorbilidades concomitantes.ResultadosCiento sesenta y nueve (4,45%) pacientes presentaron infección por la COVID-19, de los cuales fallecieron 12 (7,1%) y 32 (18,9%) requirieron ingreso hospitalario. La enfermedad respiratoria previa se relacionó con la infección por la COVID-19 (p<0,05). La maculopatía aparece en un 5,3% de los pacientes y está relacionada significativamente con la dosis de hidroxicloroquina consumida (p<0,05).ConclusiónNo existe relación entre consumo crónico de hidroxicloroquina e incidencia de la COVID-19. (AU)

Objective: To analyze the incidence of Covid-19 in patients who are chronic users of hydroxychloroquine.Patients and methodsCross-sectional retrospective observational multicenter study in health areas and districts from Castilla La-Mancha and Andalucia. Of the 4451 participants included in the first recruitment, 3817 with valid data were selected. The main variable of the study is the presence or absence of Covid-19 infection by clinical, serological or polymerase chain reaction diagnosis. Sociodemographic and clinical variables and treatment and concomitant comorbidities were recorded.Results169 (4,45%) patients had Covid-19 infection, of which 12 (7.1%) died and 32 (18.9%) required hospital admission. Previous respiratory pathology was related to Covid-19 infection (P<.05). Maculopathy appears in 5.3% of patients and is significantly related to the dose of hydroxychloroquine consumed (P<.05).ConclusionThere is no relationship between chronic use of hydroxychloroquine and the incidence of Covid-19. (AU)

[Incidence of COVID-19 in patients under chronic treatment with hydroxychloroquine]. / Incidencia de la COVID-19 en pacientes en tratamiento crónico con hidroxicloroquina.

OBJECTIVE: To analyze the incidence of Covid-19 in patients who are chronic users of hydroxychloroquine. PATIENTS AND METHODS: Cross-sectional retrospective observational multicenter study in health areas and districts from Castilla La-Mancha and Andalucia. Of the 4451 participants included in the first recruitment, 3817 with valid data were selected. The main variable of the study is the presence or absence of Covid-19 infection by clinical, serological or polymerase chain reaction diagnosis. Sociodemographic and clinical variables and treatment and concomitant comorbidities were recorded. RESULTS: 169 (4,45%) patients had Covid-19 infection, of which 12 (7.1%) died and 32 (18.9%) required hospital admission. Previous respiratory pathology was related to Covid-19 infection (P<.05). Maculopathy appears in 5.3% of patients and is significantly related to the dose of hydroxychloroquine consumed (P<.05). CONCLUSION: There is no relationship between chronic use of hydroxychloroquine and the incidence of Covid-19.

[Different methods used to estimate the prevalence of hypothyroidism, Cadiz, Spain]. / Estimación de la prevalencia de hipotiroidismo según diferentes métodos: dosis diaria definida, dosis diaria prescrita y registro de pacientes en tratamiento.

BACKGROUND: Hypothyroidism (HT) is a common condition in clinical practice. There is a paucity of recent data on its prevalence in Spain, suggesting the need for an updated estimate and therefore the aim of this study was to determine its prevalence in the province of Cádiz. METHODS: We obtained data relative to medical prescriptions for group H03AA drugs issued in primary care centers attached to the Andalusian Health Service in the province of Cadiz in 2012. Prevalence was estimated on the basis of the defined daily dose (DDD), the prescribed daily dose (DDP) and treated patient records (TPR). We present the estimated prevalence and odds ratio by gender, with a confidence interval of 95%. RESULTS: Prevalence of HT in 2012 in the population aged 15 years and over in the province of Cadiz was 1.36% (CI95: 1.33%-1.38%) based on DDD; 2.60% (CI95: 2.54%-2.66%) based on DDP; and 3.10% (CI95: 2.85%-2.93%) based on TPR. Median age was 56 years (IQR: 43 to 68). Prevalence (TPR) by gender was 0.75% in men and 5.36% in women [OR 7.26 (CI95: 7.02-7.52)]. The greatest prevalence, 9.35%, was found in the group of women aged 51 to 70 years. CONCLUSIONS: Prevalence of HT in Cadiz is high, mainly affects women. Current prescribing systems allowed us to obtain TPRs, which have been shown to be a more valuable tool than DDDs for estimating HT prevalence.

Estimación de la prevalencia de hipotiroidismo según diferentes métodos: dosis diaria definida, dosis diaria prescrita y registro de pacientes en tratamiento / Different methods used to estimate the prevalence of hypothyroidism, Cadiz, Spain

Fundamentos: El hipotiroidismo (HT) es una patología frecuente en la práctica clínica diaria. No existen datos recientes sobre su prevalencia en España. El objetivo de este trabajo fue conocer su prevalencia en la provincia de Cádiz. Métodos: Se estudió el consumo del grupo terapéutico H03AA realizado en receta oficial por las unidades de Atención Primaria (AP) de Cádiz, durante el año 2012. La prevalencia se estimó mediante tres métodos: la Dosis Diaria Definida (DDD), la Dosis Diaria Prescrita (DDP) y el Registro Pacientes en Tratamiento (RPT). Los resultados se presentaron según sexo y edad con intervalos de confianza del 95%. Resultados: La prevalencia de HT durante 2012 en población mayor de 15 años de la provincia fue del 1,36% (IC95: 1,33%-1,38%) mediante DDD, del 2,60% (IC95: 2,54%-2,66%) mediante DDP y del 3,10% (IC95: 2,85%-2,93%) mediante RPT. La mediana de edad fue de 56 años (rango intercuartílico 43 a 68 años). La prevalencia (RPT) por sexo fue de 0,75% en hombres y 5,36% en mujeres [OR 7,26 (IC95: 7,02-7,52)], siendo del 9,35% la correspondiente a mujeres de 51 a 70 años. Conclusiones: El método de estimación por RPT demuestra ser una herramienta más válida que el método DDD para evaluar la prevalencia de HT. El HT muestra, en nuestra provincia una prevalencia elevada con mayor afectación del sexo femenino (AU)

Background: Hypothyroidism (HT) is a common condition in clinical practice. There is a paucity of recent data on its prevalence in Spain, suggesting the need for an updated estimate and therefore the aim of this study was to determine its prevalence in the province of Cádiz. Methods:We obtained data relative to medical prescriptions for group H03AA drugs issued in primary care centers attached to the Andalusian Health Service in the province of Cadiz in 2012. Prevalence was estimated on the basis of the defined daily dose (DDD), the prescribed daily dose (DDP) and treated patient records (TPR). We present the estimated prevalence and odds ratio by gender, with a confidence interval of 95%. Results: Prevalence of HT in 2012 in the population aged 15 years and over in the province of Cadiz was 1.36% (CI95: 1.33%-1.38%) based on DDD; 2.60% (CI95: 2.54%-2.66%) based on DDP; and 3.10% (CI95: 2.85%-2.93%) based on TPR. Median age was 56 years (IQR: 43 to 68). Prevalence (TPR) by gender was 0.75% in men and 5.36% in women [OR 7.26 (CI95: 7.02-7.52)]. The greatest prevalence, 9.35%, was found in the group of women aged 51 to 70 years. Conclusions: Prevalence of HT in Cadiz is high, mainly affects women. Current prescribing systems allowed us to obtain TPRs, which have been shown to be a more valuable tool than DDDs for estimating HT prevalence (AU)