ABSTRACT
CLINICAL CASE: A patient with a conjunctival blister was diagnosed with pemphigus vulgaris by immunofluorescence tests performed on a conjunctival biopsy. DISCUSSION: Pemphigus vulgaris is an uncommon but serious autoimmune disease that produces blisters of the skin and mucous membranes. Ocular findings are rare, but include conjunctivitis and marginal eyelid erosions. Conjunctival blisters and erosions related to this condition have not been previously reported in the literature. This diagnosis can be made through direct immunofluorescence tests performed on biopsy samples of affected tissue. Unless the condition is properly diagnosed and treated, it has a high mortality.
Subject(s)
Autoimmune Diseases/complications , Blister/etiology , Conjunctival Diseases/etiology , Pemphigus/complications , Aged , Autoantibodies/analysis , Autoimmune Diseases/drug therapy , Autoimmune Diseases/pathology , Biopsy , Blister/pathology , Conjunctiva/immunology , Conjunctiva/pathology , Conjunctival Diseases/diagnosis , Conjunctival Diseases/drug therapy , Conjunctival Diseases/pathology , Fluorescent Antibody Technique, Direct , Humans , Hyperemia/etiology , Immunoglobulin G/analysis , Immunosuppressive Agents/therapeutic use , Male , Pemphigus/drug therapy , Pemphigus/pathology , Prednisone/therapeutic useABSTRACT
CASE REPORTS: Two male patients, 21 and 61 years old presenting with hyperemia resistant to topical treatment. Ocular examination showed reddish conjunctival mass, painless, highly vascularized in bulbar conjunctiva. The conjunctival biopsy revealed the presence of amyloid within the conjunctiva itself. CONCLUSIONS: Primary localized conjunctival amyloidosis is a rare disease. Diagnosis consists of biopsy in order to detect amyloid material in the conjunctival tissue together with a systemic evaluation in order to rule out the presence of primary systemic amyloidosis.
Subject(s)
Amyloidosis/diagnosis , Conjunctival Diseases/diagnosis , Adult , Conjunctiva/pathology , Humans , Male , Middle Aged , Visual AcuityABSTRACT
Caso clínico: Se presentan dos pacientes varones de 21 y 61 años de edad con hiperemia resistente al tratamiento tópico. En el examen ocular se observó una masa rosada, no dolorosa y muy vascularizada, en conjuntiva bulbar. La biopsia excisional diagnóstica reveló la presencia de amiloide en la sustancia propia conjuntival.Conclusiones: La amiloidosis conjuntival primaria es una enfermedad rara. El diagnóstico consiste la realización de una biopsia detectando material amiloide en el tejido conjuntival junto con un examen sistémico que descarte la presencia de una amiloidosis primaria sistémica
Case Reports: Two male patients, 21 and 61 years old presenting with hyperemia resistant to topical treatment. Ocular examination showed reddish conjunctival mass, painless, highly vascularized in bulbar conjunctiva. The conjunctival biopsy revealed the presence of amyloid within the conjunctiva itself.Conclusions: Primary localized conjunctival amyloidosis is a rare disease. Diagnosis consists of biopsy in order to detect amyloid material in the conjunctival tissue together with a systemic evaluation in order to rule out the presence of primary systemic amyloidosis
Subject(s)
Male , Humans , Amyloidosis/diagnosis , Conjunctival Diseases/diagnosis , Conjunctiva/pathology , Visual AcuityABSTRACT
CASE REPORT: We report a case of sympathetic ophthalmia (SO) developed after blunt trauma and vitrectomy (complicated with a massive suprachoroidal hemorrhage) using perfluorocarbon liquid (PFCL) for tamponade. DISCUSSION: The presentation of SO in a vitrectomized patient after severe blunt trauma with extended intra-ocular tamponade with PFCL could support the hypothesis that chronic inflammation caused by PFCL could have contributed to the development of SO. Nevertheless, there are other possible causal factors such as the trauma, the vitrectomy itself or the choroidal detachment with possible uveal incarceration at wound sites.
Subject(s)
Eye Injuries/complications , Fluorocarbons/adverse effects , Ophthalmia, Sympathetic/etiology , Vitrectomy/adverse effects , Wounds, Nonpenetrating/complications , Aged , Humans , Male , Ophthalmia, Sympathetic/diagnosisABSTRACT
CASE REPORT: A 33 year-old female with an asymptomatic pigmented mass in the iridocorneal angle of her right eye, arising from the ciliary body is presented. Ciliary body melanocytoma was suspected and conservative management recommended. After 36 months of follow-up the patient developed pain, inflammatory reaction and uncontrollable ocular hypertension, which was diagnosed as melanocytomalytic glaucoma. Tumor was removed by external iridecyclectomy and the histopathologic findings revealed necrotic melanocytoma. DISCUSSION: Ciliary body melanocytoma is a rare benign pigmented tumor that may present extension to the anterior chamber. Differential diagnosis mainly includes ciliary body melanoma, which carries a different prognosis and treatment.
Subject(s)
Ciliary Body , Nevus/diagnosis , Uveal Neoplasms/diagnosis , Adult , Female , Glaucoma/etiology , Humans , Nevus/complications , Uveal Neoplasms/complicationsABSTRACT
PURPOSE: To evaluate the usefulness of silicone-fluorsilicone copolymer oil (SiFO) as an intraoperative tool and a vitreous substitute in vitreoretinal surgery. METHODS: Handling properties of SiFO were tested and compared with those of perfluorooctane (PFO). The transparency of both substances was measured by spectrophotometry and subjectively assessed. Their tendency to dispersion was observed during injection in balanced saline solution (BSS) and after mechanized and manual shaking. Ease of injection and aspiration through small-gauge instruments was evaluated. Ocular tolerance to SiFO and PFO was studied after intravitreal injection in rabbit eyes: intraocular pressure, anterior segment inflammatory response and dispersion were evaluated, and a histopathological study was performed. RESULTS: Injection and aspiration of SiFO were more difficult than those of PFO because of its higher viscosity. PFO dispersed progressively into small droplets as early as two days after intravitreal injection, whereas SiFO remained as a single bubble for 14 days. Histopathologically both substances induced an inflammatory response over the inferior retina, with microvacuolated macrophages and foreign body giant cells, which were larger in eyes wearing SiFO. CONCLUSIONS: SiFO may be useful as an intraoperative tool, although its main drawback is a more difficult injection and aspiration compared to PFO. It has been well tolerated as a short-term vitreous substitute, but further clinical studies are needed.
