Sustainable integration of digitalisation in nursing education-an international scoping review.

Introduction: Trainees and teachers at nursing schools as well as nursing professionals are increasingly facing new challenges as a result of the digital transformation. Opportunities for the entire care system exist in the improvement of care quality and communication between those involved. However, this change also harbours risks, such as the use of immature digital applications in the care sector, data theft and industrial espionage. In order to be able to exploit the potential of digitalisation despite these risks, it is necessary to integrate relevant aspects such as digital skills into nursing training. The aim of this study is to investigate the extent to which the sustainable integration of digitalisation in nursing education is discussed. Methods: The methods of the systematic literature and database search were carried out in the form of a scoping review according to the PRISMA scheme. The PubMed and CINAHL databases were used for this purpose. The search period covered the years 2017-2023. Findings: After screening the titles and abstracts using inclusion and exclusion criteria, 13 studies were included in the synthesis of findings. The international literature focuses on content areas that highlight trends in digitalisation-related training in nursing. These focal points include concept development, considering the heterogeneity of demand constellations, as well as the reflexive reorientation of existing competences, whereby the technological competence of teachers is not disregarded. Other focal points relate to the initiation of digital skills in training and maintaining the employability of older nursing staff through professional development. Discussion: The literature research shows that there is a rudimentary discussion about digitalisation and curricular developments in nursing training in an international context, while the discourse in the German-language literature is less advanced. Among the sustainability desiderata derived from the literature is the involvement of nursing professionals in the development, testing and implementation of digital technologies. Only through active cooperation between nursing professionals and nursing sciences can the topic of digitalisation be integrated into the education and training of professional nursing in a targeted and future-oriented manner, whereby the focus should always be on the ability to deal with digital technologies and the associated change.

PAIN2.0: study protocol for a multicentre randomised controlled trial to evaluate the efficacy of a 10-week outpatient interdisciplinary multimodal pain therapy to manage recurrent pain for patients with risk factors of developing chronic pain in Germany.

BACKGROUND: Up to 27% of the German population suffers from recurrent or persistent pain (lasting more than three months). Therefore, prevention of chronic pain is one major object of pain management interventions. The aim of this nationwide, multicentre, randomised controlled trial is to evaluate the efficacy of a 10-week ambulatory (outpatient) interdisciplinary multimodal pain therapy (A-IMPT) for patients with recurrent pain and at risk of developing chronic pain. This project was initiated by the German Pain Society (Deutsche Schmerzgesellschaft e.V.) and the public health insurance provider BARMER. It is currently funded by the German Innovation Fund (01NVF20023). The study PAIN2.0 focuses on reducing pain intensity and pain-related disability and investigates whether this intervention can improve physical activity, psychological well-being, and health literacy. METHODS: PAIN2.0 is designed as a multicentre 1:1 randomised controlled trial with two parallel groups (randomisation at the patient level, planned N = 1094, duration of study participation 12 months, implemented by 22 health care facilities nationwide). After 6 months, patients within the control group also receive the intervention. The primary outcomes are pain intensity and pain-related impairment, measured as Characteristic Pain Intensity (PI) and Disability Score (DS) (Von Korff), as well as patient-related satisfaction with the intervention. Secondary outcomes are the number of sick leave days, sickness allowance, treatment costs, psychological distress, health-related quality of life, and catastrophizing. The effects of the intervention will be analysed by a parallel-group comparison between the intervention and control groups. In addition, the long-term effects within the intervention group will be observed and a pre-post comparison of the control group before and after the intervention will be performed. DISCUSSION: Recurrent or persistent pain is common in the German population and causes high costs for patients and society. The A-IMPT aims to improve pain and pain-related impairments in pain patients at risk of chronification, thereby reducing the risk of developing chronic pain with its high socioeconomic burden. This new therapy could easily be integrated into existing therapy programs if positively evaluated. TRIAL REGISTRATION: The trial PAIN2.0 has been registered in the German Clinical Trials Register (DRKS) since 21/11/2022 with the ID DRKS00030773 .

[Compatibility of occupation with nursing relatives in small and medium-sized businesses : Results of an explorative study in a "rural urban" center in eastern Lower Saxony]. / Vereinbarkeit von Berufstätigkeit und Angehörigenpflege in kleinen und mittleren Unternehmen : Ergebnisse einer explorativen Studie in einem "rural-urbanen" Zentrum im Osten Niedersachsens.

In view of the increasing duties of employees as caregivers for relatives, questions arise concerning the compatibility of work and caregiving in the context of small and medium-sized enterprises. The aim of this exploratory study was to give first insights into this issue whereby the related perceptions and needs of this group were investigated. The research included semi-structured interviews with company executives and two workshops with employees according to the photovoice method. The results showed that the enterprises preferred informal in contrast to formal arrangements. Also, they did not have any knowledge concerning the care-related needs of their employees. The chief executive officers showed a highly superficial awareness of this problem. On the employees side the organizational efforts to maintain the care arrangement at home were articulated as a main issue, which could be supported by flexible working time regulations; however, in the current practice this was granted by the employers at the expense of their employees.

Proteomic analysis of mitotic RNA polymerase II reveals novel interactors and association with proteins dysfunctional in disease.

RNA polymerase II (RNAPII) transcribes protein-coding genes in eukaryotes and interacts with factors involved in chromatin remodeling, transcriptional activation, elongation, and RNA processing. Here, we present the isolation of native RNAPII complexes using mild extraction conditions and immunoaffinity purification. RNAPII complexes were extracted from mitotic cells, where they exist dissociated from chromatin. The proteomic content of native complexes in total and size-fractionated extracts was determined using highly sensitive LC-MS/MS. Protein associations with RNAPII were validated by high-resolution immunolocalization experiments in both mitotic cells and in interphase nuclei. Functional assays of transcriptional activity were performed after siRNA-mediated knockdown. We identify >400 RNAPII associated proteins in mitosis, among these previously uncharacterized proteins for which we show roles in transcriptional elongation. We also identify, as novel functional RNAPII interactors, two proteins involved in human disease, ALMS1 and TFG, emphasizing the importance of gene regulation for normal development and physiology.

Drosophila BAP60 is an essential component of the Brahma complex, required for gene activation and repression.

The SWI/SNF-like chromatin remodeling complex of Drosophila, the Brahma complex, contains four subunits (Brahma, BAP155/Moira, SNR1 and BAP60) conserved from yeast to humans. A reconstituted human complex lacking the BAP60 homolog shows full remodeling activity, suggesting that BAP60 is not essential for the core function. We generated Drosophila mutants and found that BAP60 carries a vital function and participates in complex-mediated transcriptional activation and repression. BAP60 binds DNA and shows genetic and physical interactions with the sex-determining transcription factors encoded by sisterless A and scute. The results support the conclusion that BAP60 participates in site-specific recruitment of the Brahma complex in Drosophila.

Judgement of risk in traumatized and nontraumatized emergency medical service personnel.

This study investigated the hypothesis that posttraumatic stress is associated with a judgement of risk bias, defined as an overestimation of the likelihood of the occurrence of adverse events, as proposed by information-processing theories of posttraumatic stress disorder. Emergency medical service personnel with high PTSD symptomatology (n =27) and without PTSD symptoms (n = 74) completed the PTSD Symptom Scale: Self-report version, the Work Experiences Questionnaire, the Beck Depression Inventory, and an Event Probability Questionnaire. Analysis showed that individuals with high PTSD symptomatology exhibited significantly more judgement of risk bias, that this cognitive bias was towards a wider range of threats than those involving only the threat of external harm, and that intrusion was its best predictor.

The irrational beliefs inventory: cross-cultural comparisons between South African and previously published Dutch and American samples.

The Irrational Beliefs Inventory gives a measure of irrational beliefs, as postulated by Ellis's Rational Emotive Behavior therapy. Given the increasing cross-cultural use of psychometric scales, it is important to assess whether the psychometric properties of the inventory are consistent across cultures. In the present study cross-cultural applicability, in terms of internal consistency and independence of subscales, was investigated for an ad hoc sample of White (n= 100, M age = 21.3 yr., SD=4.0) and Black (n=82, M age=19.8 yr., SD=2.2) undergraduate South African university students. Cronbach coefficients alpha for the subscales and Pearson correlations between subscales for American and Dutch students, as reported by Bridges and Sanderman, were compared with those indices for the South African students. The magnitude and rank order of Cronbach alpha, as well as the correlations between subscales for the three groups showed strong similarities. Values of alpha for the Black South African students were lower in magnitude on all subscales than those for American, Dutch, and White South African samples, but intercorrelations between subscale scores were consistent. Findings in the present study are supportive of the cross-cultural applicability of the Irrational Beliefs Inventory to White South African students but not to South African Black students.

Posttraumatic stress and depressive symptomatology in a sample of battered women from South Africa.

This study investigated the incidence of depression, posttraumatic stress symptomatology, anger, and guilt in a sample of 40 battered women in a shelter. Analysis indicated that 63% of the 40 scored moderate to severe on depression, 59% manifested high posttraumatic stress symptoms, while 38.4% and 54.5% reported problems with anger and guilt, respectively. Frequency and severity of physical abuse were not correlated with depressive or posttraumatic stress symptomatology.