Subject(s)
Dental Plaque/physiopathology , Sucrose/pharmacology , Tooth/physiology , Adult , Female , Humans , Hydrogen-Ion Concentration , Male , Saliva/physiologySubject(s)
Amines/metabolism , Amino Alcohols , Dental Enamel/ultrastructure , Fluorides/metabolism , Hydroxides/pharmacology , Potassium Compounds , Potassium/pharmacology , Sodium Fluoride/metabolism , Amines/administration & dosage , Chemical Precipitation , Crystallography , Dental Enamel/metabolism , Fluorides/administration & dosage , Fluorides, Topical/metabolism , Humans , Microscopy, Electron, Scanning , Sodium Fluoride/administration & dosage , WaterSubject(s)
Preventive Dentistry , Animals , Child , Child, Preschool , Dental Caries/prevention & control , Dental Plaque/microbiology , Fluorides/therapeutic use , Humans , Periodontal Diseases/prevention & control , Preventive Dentistry/economics , Preventive Dentistry/education , Public Relations , SwitzerlandSubject(s)
Dental Plaque/prevention & control , Fluorides/therapeutic use , Hexetidine/therapeutic use , Mouthwashes/therapeutic use , Zinc Compounds , Zinc/therapeutic use , Adult , Animals , Clinical Trials as Topic , Dental Plaque/microbiology , Dental Plaque Index , Double-Blind Method , Drug Combinations , Drug Evaluation, Preclinical , Drug Synergism , Female , Humans , Rats , Rats, Inbred StrainsABSTRACT
N,N,N',N'-ethylene diamine tetra (methylene phosphonic acid)--EDITEMPA--was highly effective in reducing dental calculus formation in beagle dogs when applied topically as a 1% solution or in a mouth rinse. A dose-response study in 40 beagles for 12 weeks with dentifrices containing 1, 2, 2.75, and 2.75% EDITEMPA + 0.1% NaF gave a significant (alpha = 0.05) reduction in calculus formation. Based on these results, it was also concluded that 0.1% NaF did not affect the anticalculus activity of 2.75% EDITEMPA. The effect of EDITEMPA dentifrice on dental caries in rats was also studied. A dentifrice containing 1.69% EDITEMPA significantly (alpha less than 0.01) reduced smooth and fissure caries in rats when applied topically. Collectively, the data suggested that EDITEMPA was an effective anticalculus agent and that it did not damage developing enamel in vivo.