The impact of hippocampal damage on appetitive control.

Animal data indicates the hippocampus assists appetite-regulation.  We tested this in humans, contrasting two patients (DW, JC) with hippocampal damage to controls on an appetite-regulation test conducted hungry and sated.  When hungry, controlsviewed palatable snacks and reported a desire to eat them, a memory-based judgment.  After sampling them, they reported liking their taste.  Post-lunch (DW ate little, precluding a test of our hypothesis), controls showed a large decrease in desire for the snacks, but less change in taste-liking.  JC ate like controls, but reported no change in desire across states, suggesting that the human hippocampus also contributes to appetite-regulation.