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1.
Fitoterapia ; 151: 104869, 2021 Jun.
Article in English | MEDLINE | ID: mdl-33657429

ABSTRACT

The phytochemical study of leaves of Funtumia elastica led to the isolation of three undescribed ursane derivatives, funtumic acids A, B and C (1-3), as well as one steroidal alkaloid, elasticine (4) and five other known compounds (5-9). Their structures were elucidated on the basis of NMR, MS, IR, UV spectroscopic data as well as by comparison with the literature. The compound 5-hydroxypyridine-3-carboxamide (9) was isolated for the first time from the Apocynaceae family. All the isolated compounds were evaluated for their antiparasitic effects against 3D7 and Dd2 strains of Plasmodium falciparum and promastigotes of Leishmania donovani (MHOM/SD/62/1S). Compounds 1-4 possessed good in vitro antimalarial activities against CQR Dd2 with IC50 values ranging from 4.68 to 5.36 µg/mL and moderate on CQS 3D7. Only compounds 1 and 2 showed leishmanicidal activities with IC50 values ranging between 10.49 and 13.21 µg/mL. In addition, crude extract exhibited potent antiplasmodial (IC50 0.91 and 3.12 µg/mL) and antileishmanial (IC50 3.32 µg/mL) activities, thus demonstrating their potential synergistic action.


Subject(s)
Alkaloids/pharmacology , Antimalarials/pharmacology , Antiprotozoal Agents/pharmacology , Apocynaceae/chemistry , Triterpenes/pharmacology , Alkaloids/isolation & purification , Animals , Antimalarials/isolation & purification , Antiprotozoal Agents/isolation & purification , Cameroon , Leishmania donovani/drug effects , Mice , Molecular Structure , Phytochemicals/isolation & purification , Phytochemicals/pharmacology , Plant Leaves/chemistry , Plasmodium falciparum/drug effects , RAW 264.7 Cells , Triterpenes/isolation & purification
2.
Nat Prod Res ; 35(23): 5535-5539, 2021 Dec.
Article in English | MEDLINE | ID: mdl-32657142

ABSTRACT

The methanolic extract of the waste seeds of Sesamum indicum L. (Pedaliaceae) was subjected to chromatographic fractionation; it led to the isolation of an alkyl benzene identified as 1,3-bis (pentadecyl)benzene (1) along with three known fatty acids: oleic acid (2), linoleic acid (3), and palmitic acid (4); one monosaturated cardanol, 3-pentadecylphenol (5) and two phytosteroids identified as sitostanol (6) and campestanol (7). The structures of these compounds were elucidated by chemical and spectroscopic analyses. Compounds 1, 5 and 6 were evaluated against protozoan parasites. Compound 1 moderately inhibited the promastigote form of Leishmania donovani LG13 with IC50 equal to 16.9 µM.


Subject(s)
Antiprotozoal Agents , Pedaliaceae , Sesamum , Antiprotozoal Agents/pharmacology , Benzene , Plant Extracts
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