ABSTRACT
SPTBN2 is a protein-coding gene that is closely related to the development of malignant tumors. However, its prognostic value and biological function in pan-cancer, especially pancreatic cancer (PAAD), have not been reported. In the present study, a novel exploration of the value and potential mechanism of SPTBN2 in PAAD was conducted using multi-omics in the background of pan-cancer. Via various database analysis, up-regulated expression of SPTBN2 was detected in most of the tumor tissues examined. Overexpression of SPTBN2 in PAAD and kidney renal clear cell cancer patients potentially affected overall survival, disease-specific survival, and progression-free interval. In PAAD, SPTBN2 can be used as an independent factor affecting prognosis. Mutations and amplification of SPTBN2 were detected, with abnormal methylation of SPTBN2 affecting its expression and the survival outcome of PAAD patients. Immunoassay results demonstrate that SPTBN2 was a potential biomarker for predicting therapeutic response in PAAD, and may influence the immunotherapy efficacy of PAAD by regulating levels of CD8 + T cells and neutrophil infiltration. Results from an enrichment analysis indicated that SPTBN2 may regulate the development of PAAD via immune pathways. Thus, SPTBN2 is a potential prognostic biomarker and immunotherapy target based on its crucial role in the development of PAAD.
Subject(s)
Biomarkers, Tumor , Gene Expression Regulation, Neoplastic , Pancreatic Neoplasms , Humans , Pancreatic Neoplasms/genetics , Pancreatic Neoplasms/pathology , Pancreatic Neoplasms/mortality , Pancreatic Neoplasms/therapy , Pancreatic Neoplasms/metabolism , Biomarkers, Tumor/genetics , Biomarkers, Tumor/metabolism , Prognosis , Spectrin/metabolism , Spectrin/genetics , Male , Female , Mutation , DNA Methylation , MultiomicsABSTRACT
Three-dimensional topological nodal lines, the touching curves of two bands in momentum space, which give rise to drumhead surface states, provide an opportunity to explore a variety of exotic phenomena. However, solid evidence for a flat drumhead surface state remains elusive. In this paper, we report a realization of three-dimensional nodal line dispersions and drumhead surface states in phononic crystal. Profiting from its macroscopic nature, the phononic crystal permits a flexible and accurate fabrication for materials with ring-like nodal lines and drumhead surface states. Phononic nodal rings of the lowest two bands and, more importantly, topological drumhead surface states are unambiguously demonstrated. Our system provides an ideal platform to explore the intriguing properties of acoustic waves endowed with extraordinary dispersions.
ABSTRACT
Valley topological materials, in which electrons possess valley pseudospin, have attracted a growing interest recently. The additional valley degree of freedom offers a great potential for its use in information encoding and processing. The valley pseudospin and valley edge transport have been investigated in photonic and phononic crystals for electromagnetic and acoustic waves, respectively. In this work, by using a micromanufacturing technology, valley topological materials are fabricated on silicon chips, which allows the observation of gyral valley states and valley edge transport for elastic waves. The edge states protected by the valley topology are robust against the bending and weak randomness of the channel between distinct valley Hall phases. At the channel intersection, a counterintuitive partition of the valley edge states manifests for elastic waves, in which the partition ratio can be freely adjusted. These results may enable the creation of on-chip high-performance micro-ultrasonic materials and devices.
