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Neurotoxicology ; 64: 19-29, 2018 01.
Article in English | MEDLINE | ID: mdl-28587807

ABSTRACT

This study examines the results of neuropsychological testing of 26 active welders and 17 similar controls and their relationship to welders' shortened MRI T1 relaxation time, indicative of increased brain manganese (Mn) accumulation. Welders were exposed to Mn for an average duration of 12.25 years to average levels of Mn in air of 0.11±0.05mg/m3. Welders scored significantly worse than controls on Fruit Naming and the Parallel Lines test of graphomotor tremor. Welders had shorter MRI T1 relaxation times than controls in the globus pallidus, substantia nigra, caudate nucleus, and the anterior prefrontal lobe. 63% of the variation in MRI T1 relaxation times was accounted for by exposure group. In welders, lower relaxation times in the caudate nucleus and substantia nigra were associated with lower neuropsychological test performance on tests of verbal fluency (Fruit Naming), verbal learning, memory, and perseveration (WHO-UCLA AVLT). Results indicate that verbal function may be one of the first cognitive domains affected by brain Mn deposition in welders as reflected by MRI T1 relaxation times.


Subject(s)
Brain/diagnostic imaging , Manganese Poisoning/diagnosis , Occupational Exposure , Welding , Adult , Brain/pathology , Humans , Magnetic Resonance Imaging , Male , Manganese Poisoning/pathology , Manganese Poisoning/psychology , Middle Aged , Neuropsychological Tests
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