1.
Asian Pac J Cancer Prev
; 13(8): 3695-700, 2012.
Article
in English
| MEDLINE
| ID: mdl-23098456
ABSTRACT
Mammalian mediator (MED) is a multi-protein coactivator that has been identified by several research groups. The involvement of the MED complex subunit 19 (MED 19) in the metastasis of lung adenocarcinoma cell line (H1299), which expresses the MED 19 subunit, was here investigated. When MED 19 expression was decreased by RNA interference H1299 cells demonstrated reduced clone formation, arrest in the S phase of the cell cycle, and lowered metastatic capacity. Thus, MED 19 appears to play important roles in the biological behavior of non-small cell lung carcinoma cells. These findings may be important for the development of novel lung carcinoma treatments.
Subject(s)
Carcinoma, Non-Small-Cell Lung/secondary , Cell Movement , Cell Proliferation , Cell Transformation, Neoplastic , Lung Neoplasms/pathology , Mediator Complex/antagonists & inhibitors , S Phase/physiology , Apoptosis , Blotting, Western , Carcinoma, Non-Small-Cell Lung/metabolism , Cell Adhesion , Clone Cells/metabolism , Clone Cells/pathology , Flow Cytometry , Humans , Lung Neoplasms/metabolism , Mediator Complex/genetics , Mediator Complex/metabolism , RNA, Small Interfering/genetics , Tumor Cells, Cultured
2.
Zhonghua Jie He He Hu Xi Za Zhi
; 31(2): 134-6, 2008 Feb.
Article
in Chinese
| MEDLINE
| ID: mdl-18683787