ABSTRACT
PURPOSE: Hepatocellular carcinoma (HCC) is a histological type of primary liver cancer, with high recurrence and mortality rates worldwide. At the moment, there are no diagnostic and prognostic markers. microRNAs (miRs) are short-chain non-coding RNAs, and play a vital role in tumor diagnosis and prognosis. METHODS: The miR-187 and miR-509-3p expression in primary HCC was evaluated via qRT-PCR and starBase, and the diagnostic and prognostic values were analyzed via receiver operating characteristic (ROC) curve and Kaplan-Meier method. RESULTS: qRT-PCR and starBase analysis showed that the miR-187 expression was low in the tissues and serum of primary HCC patients, while that of miR-509-3p increased. ROC analysis manifested that the area under the curves (AUCs) of miR-187 and miR-509-3p in primary HCC were 0.842 and 0.866, respectively, and that of joint diagnosis was > 0.9. The 5-year survival rates of miR-187 low expression group and miR-509-3p high expression group decreased markedly. Cox regression analysis identified that pathological differentiation, clinical stage and miR-187 were independent prognostic factors of primary HCC patients. CONCLUSION: miR-187 and miR-509-3p.
