[The effect of surface modification strategies on biological activity of titanium implant].

The surface morphology of titanium metal is an important factor affecting its hydrophilicity and biocompatibility, and exploring the surface treatment strategy of titanium metal is an important way to improve its biocompatibility . In this study , titanium (TA4) was firstly treated by large particle sand blasting and acid etching (SLA) technology, and then the obtained SLA-TA4 was treated by single surface treatments such as alkali-heat, ultraviolet light and plasma bombardment. According to the experimental results, alkali-heat treatment is the best treatment method to improve and maintain surface hydrophilicity of titanium. Then, the nanowire network morphology of titanium surface and its biological property, formed by further surface treatments on the basis of alkali-heat treatment, were investigated. Through the cell adhesion experiment of mouse embryonic osteoblast cells (MC3T3-E1), the ability of titanium material to support cell adhesion and cell spreading was investigated after different surface treatments. The mechanism of biological activity difference of titanium surface formed by different surface treatments was investigated according to the contact angle, pit depth and roughness of the titanium sheet surface. The results showed that the SLA-TA4 titanium sheet after a treatment of alkali heat for 10 h and ultraviolet irradiation for 1 h has the best biological activity and stability. From the perspective of improving surface bioactivity of medical devices, this study has important reference value for relevant researches on surface treatment of titanium implantable medical devices.

Optogenetic therapeutic strategies for diabetes mellitus.

Diabetes mellitus (DM) is a common chronic disease affecting humans globally. It is characterized by abnormally elevated blood glucose levels due to the failure of insulin production or reduction of insulin sensitivity and functionality. Insulin and glucagon-like peptide (GLP)-1 replenishment or improvement of insulin resistance are the two major strategies to treat diabetes. Recently, optogenetics that uses genetically encoded light-sensitive proteins to precisely control cell functions has been regarded as a novel therapeutic strategy for diabetes. Here, we summarize the latest development of optogenetics and its integration with synthetic biology approaches to produce light-responsive cells for insulin/GLP-1 production, amelioration of insulin resistance and neuromodulation of insulin secretion. In addition, we introduce the development of cell encapsulation and delivery methods and smart bioelectronic devices for the in vivo application of optogenetics-based cell therapy in diabetes. The remaining challenges for optogenetics-based cell therapy in the clinical translational study are also discussed.

Construction of a tetrabenzotetrathia[8]circulene by a "fold-in" oxidative fusion reaction: synthesis and optical properties.

Herein we report the first synthesis of a tetrabenzotetrathia[8]circulene by a "fold-in" type oxidative fusion reaction. Compared to the pristine tetrathia[8]circulene, the four-fold benzoannulation slightly weakened the antiaromatic character of the central COT ring. The tetrabenzotetrathia[8]circulene exhibited fluorescence at room temperature, and phosphorescence at 77 K with a phosphorescence quantum yield of 11.7%.

Specific effects of cumulative childhood trauma on suicidality among youths.

BACKGROUND: Suicidality was very high among individuals who suffered from childhood trauma. The distribution of cumulative childhood trauma among youths remains unclear, as well as the specific effects of cumulative childhood trauma on suicidality. This study attempted to explore the distribution of cumulative childhood trauma and examine the specific effects of cumulative childhood trauma on suicidality. METHODS: A cross-sectional design was employed in this study, with 117,769 college students recruited from 63 universities in Jilin Province, China. All variables were measured by corresponding self-report questionnaires. The Venn diagram was used to represent the distribution of single and cumulative childhood trauma. ANOVA and chi-square tests were conducted to identify the high-risk suicide groups. Multiple linear regression analysis was performed to examine risk factors for suicidality for overlapping subtypes. RESULTS: 27,671 (23.5%) participants reported suffering from childhood trauma, of which 49.5% were male (Mage = 19.59, SD = 1.76). The "physical neglect" group accounted for the largest proportion (31.5%). Suicidality was the highest in the "overlap of childhood neglect, emotional abuse, and physical abuse" group (2.0%). Depression, obsessive-compulsive disorder, and post-traumatic stress disorder were common risk factors for suicidality. LIMITATIONS: This study was limited by cross-sectional studies and self-report bias. CONCLUSIONS: The childhood trauma subtype group with the largest proportion was not necessarily the highest suicidality. Both the largest group and the highest-risk suicide group require special attention to their respective risk factors.

Highly reversible zinc metal anode enabled by strong Brønsted acid and hydrophobic interfacial chemistry.

Uncontrollable zinc (Zn) plating and hydrogen evolution greatly undermine Zn anode reversibility. Previous electrolyte designs focus on suppressing H2O reactivity, however, the accumulation of alkaline byproducts during battery calendar aging and cycling still deteriorates the battery performance. Here, we present a direct strategy to tackle such problems using a strong Brønsted acid, bis(trifluoromethanesulfonyl)imide (HTFSI), as the electrolyte additive. This approach reformulates battery interfacial chemistry on both electrodes, suppresses continuous corrosion reactions and promotes uniform Zn deposition. The enrichment of hydrophobic TFSI- anions at the Zn|electrolyte interface creates an H2O-deficient micro-environment, thus inhibiting Zn corrosion reactions and inducing a ZnS-rich interphase. This highly acidic electrolyte demonstrates high Zn plating/stripping Coulombic efficiency up to 99.7% at 1 mA cm-2 ( > 99.8% under higher current density and areal capacity). Additionally, Zn | |ZnV6O9 full cells exhibit a high capacity retention of 76.8% after 2000 cycles.

Modeling perceived parental attitudes and mental well-being in Chinese young LGBTQ+ individuals: Investigation of weekly diary data using dynamic network analysis.

Existing literature has reported negative parental attitudes toward LGBTQ+ individuals associated with their LGBTQ+ identity concealment and mental well-being. However, limited research has explored the dynamic network changes using intensive, repeated weekly diary data. This study aimed to model the associations between perceived parental attitude, anxiety, depression, and LGBTQ+ individuals' identity concealment within dynamic network analysis (DNA); 103 LGBTQ+ youth participated in the study. Participants' perceived parental attitudes toward LGBTQ+ identity and LGBTQ+ identity concealment, depression (by the 9-item Patient Health Questionnaire), and anxiety (by the 7-item Generalized Anxiety Disorder Questionnaire) were measured. Each was assessed four times at 1-week intervals for four consecutive weeks. The graphical vector autoregression explored the DNA of the internal relationships among perceived parental attitudes, identity concealment, depression, and anxiety. Findings in the between-subjects network revealed that poor perceived parental attitudes toward sexual and gender minorities were positively associated with depression, anxiety, and identity concealment. The contemporaneous network showed that the "expression" (one's identity concealment) was the direct trigger of "suicide" (one's depressive symptom), indicating depression was initiated earlier and subsequently exacerbated a sequence of other psychiatric reactions. The temporal network indicated that only parents' "general attitude" reduced participants' concealment ("self-disclosure"), which simultaneously stimulated mental benefits.

Psychometric Properties of the Chinese Version of 20-Item Zimbardo Time Perspective Inventory (C-ZTPI-20) in Chinese Adolescent Population.

Background: This study assesses the psychometric properties of the Chinese version of the Zimbardo Time Perspective Inventory (C-ZTPI-20) in an adolescent population. Methods: The investigation encompasses a sample of 2634 middle school students from China and aims to evaluate the instrument's reliability, structural validity, measurement invariance, criterion validity, and network structure attributes. Results: First, descriptive analysis revealed satisfactory reliabilities for four out of five C-ZTPI-20 dimensions, with Present Fatalistic (PF) exhibiting relatively low reliability. Moreover, Confirmatory Factor Analysis (CFA) supported the 5-dimensional structure across all samples and sexes, albeit with a modest Tucker-Lewis Index (TLI) for girls. Furthermore, measurement invariance analysis underscores unbiased assessment across sexes. Sex differences emerge in the Present Hedonistic (PH) dimension, where boys showed higher scores. Furthermore, criteria validity analysis revealed that Past Positive (PP) and Future (F) were positively associated with extraversion, agreeableness, conscientiousness, openness, grit, and mental health, while they were negatively associated with neuroticism. Past Negative (PN) and PF showed inverse trends, while PH perspective demonstrated complex, varied correlations with these psychological traits, underscoring the multifaceted nature of time perspectives. Finally, network analysis revealed positive inter-correlations within dimensions and significant edge differences between sexes, particularly in inter-dimension connections. Despite differing rankings, the most central and marginal items remained consistent between boys and girls in network models. Conclusion: These findings contribute to understanding the C-ZTPI-20's effectiveness in assessing adolescent time perspectives and inform interventions promoting psychological well-being and coping strategies.

A Systematic Solution for Moving-Target Detection and Tracking While Only Using a Monocular Camera.

This paper focuses on moving-target detection and tracking in a three-dimensional (3D) space, and proposes a visual target tracking system only using a two-dimensional (2D) camera. To quickly detect moving targets, an improved optical flow method with detailed modifications in the pyramid, warping, and cost volume network (PWC-Net) is applied. Meanwhile, a clustering algorithm is used to accurately extract the moving target from a noisy background. Then, the target position is estimated using a proposed geometrical pinhole imaging algorithm and cubature Kalman filter (CKF). Specifically, the camera's installation position and inner parameters are applied to calculate the azimuth, elevation angles, and depth of the target while only using 2D measurements. The proposed geometrical solution has a simple structure and fast computational speed. Different simulations and experiments verify the effectiveness of the proposed method.

Clinical outcomes of different muscle flap reconstruction after inguinal tumor resection: A case series.

PURPOSE: To introduce the clinical outcomes of adductor longus and sartorius muscle transfer alone and combined application for reconstruction of the inguinal region. METHODS: This is a retrospective study of patients between January 2019 and December 2022 who underwent adductor longus flap transfer, sartorius muscle flap transfer, and combined transfer of adductor longus and sartorius muscle. The demographic data and surgical details were recorded. RESULTS: Sixteen patients were included, with a mean age of 57.5 years. Nine patients performed adductor longus flap transfers, three patients performed sartorius muscle flap transfers, and four patients performed combined transfers. The average operation time was 238 min. The average length of stay was 6.7 days. The average follow-up period was 9.6 months (range 6-16). The overall early postoperative complication rate was 12.5% (one patient had excessive wound exudation and one patient had a wound infection). No delayed postoperative complications occurred during the follow-up. CONCLUSION: The sartorius muscle flap, the adductor longus flap, and the combined application are suitable techniques for inguinal region reconstruction under different conditions. The combined application of the two flaps can fill the dead space and cover the neurovascular bundle efficaciously.

Network structure of the links between extracurricular time-use and delinquent behaviors: Moving forward and beyond linear relations.

Using psychological network analysis, this study explored the heterogeneity of the network structure between extracurricular time-use and delinquency using a nationally representative longitudinal survey of at-school students in China (N = 10,279, 47.3% female, average age 13.6, 91.2% Han ethnicity). The results are threefold: First, time stimulation of activities occurs on weekdays, while time displacement and stimulation occur on weekends. Second, delinquent behaviors are positively correlated, forming a problem behavior syndrome. Smoking or drinking is the central delinquent behavior. Third, negative consequences of specific time-use behaviors are more likely to occur on weekends than on weekdays, and time-use behavior may function differently on weekdays versus weekends. Among them, going to coffeenets or game-centers serves as the bridge with the highest potential of triggering delinquency.

m6A­mediated LINC02038 inhibits colorectal cancer progression via regulation of the FAM172A/PI3K/AKT pathway via competitive binding with miR­552­5p.

Long noncoding RNAs (lncRNAs) are a type of regulatory molecule with potential roles in the development of several different malignancies. However, the underlying mechanisms of lncRNAs in colorectal cancer (CRC) are incompletely understood. The present study investigated the molecular mechanism of LINC02038 in CRC. LINC02038 expression was decreased in CRC tissues compared to the para­cancerous tissues and LINC02038 overexpression markedly reduced the proliferation, vitality, migration and invasive ability and greatly accelerated apoptosis of colorectal cancer cells. Bioinformatics examination indicated that LINC02038 may have targeted microRNA (miR)­552­5p. RNA immunoprecipitation and luciferase reporter assays showed that LINC02038 served as a sponge for miR­552­5p, hindering target gene FAM172A of miR­552­5p degradation. Moreover, methylated RNA immunoprecipitation (MeRIP)­qualitative PCR assays revealed that YTHDF2 could identify and regulate the METTL3­mediated LINC02038 N6­methyladenosine (m6A) modification and increase its degradation, thereby promoting CRC progression via the PI3K/AKT pathway. Based on the CRC clinical specimens, it was shown that LINC02038 was negatively associated with lymphatic metastasis and distant metastasis. These results revealed that m6A/LINC02038/miR­552­5p/FAM172A may be a novel anti­tumor axis and LINC02038 may serve as a biomarker and treatment option for colorectal cancer.

Comparative study of preoperative sagittal alignment between patients with multisegment cervical ossification of the posterior longitudinal ligament and cervical spondylotic myelopathy.

BACKGROUND CONTEXT: Preoperative sagittal alignment is of great significance in the development of spinal deformities, degenerative diseases, preoperative planning, postoperative clinical evaluation, and functional recovery. However, few reports have focused on the difference in preoperative sagittal alignment between patients with ossification of the posterior longitudinal ligament (OPLL) and patients with cervical spondylotic myelopathy (CSM). PURPOSE: To compare preoperative sagittal alignment between patients with multisegment cervical OPLL and multilevel CSM. STUDY DESIGN: Retrospective study. PATIENT SAMPLE: A total of 243 patients were included in this study. OUTCOME MEASURES: The outcome measures were the Japanese Orthopaedic Association (JOA) score, visual analog scale (VAS) score, number of hand actions in 10 seconds, hand-grip strength, C2 to C7 Cobb angle, C2 to C5 Cobb angle, C5 to C7 Cobb angle, C2 to C7 sagittal vertical axis, C7 slope, T1 slope, K-line, K-line tilt, and range of motion (ROM). METHODS: The outcome measures were calculated in the OPLL group and CSM group and the data were analyzed using the unpaired t-test, χ² test, and one-way analysis of variance. RESULTS: A total of 243 patients (136 men, 107 women; mean age, 59.1±10.6 years) underwent surgical treatment from September 2013 to December 2021. In total, 123 patients were diagnosed with multisegment cervical OPLL, including continuous type (n=39), segmental type (n=38), and mixed type (n=46). The remaining 120 patients had multisegment CSM. The disease course in the OPLL group was significantly shorter than that in the CSM group (p<.05). Among the above preoperative measurements, the JOA score, number of hand actions in 10 seconds, hand-grip strength, and VAS score were not significantly different between the two groups (p>.05). The C2 to C7 Cobb angle was significantly larger in the OPLL than CSM group (17.7°±9.2° and 14.9°±9.3°, respectively; p< .05), as was the C5 to C7 Cobb angle (10.0°±6.3° and 7.5°±6.1°, respectively; p<.05). The ROM was significantly smaller in the OPLL than CSM group (33.1°±8.1° and 40.1°±10.9°, respectively; p<.001). Within the OPLL group, the ROM was significantly smaller in the continuous type than in the segmental type (p<.05). CONCLUSION: Patients with multisegment cervical OPLL have greater lordotic preoperative sagittal alignment and smaller preoperative ROM than patients with CSM.

Psychometric Properties of the Chinese Version of the 10-Item Social Provisions Scale in Chinese Populations.

This study performed a cross-cultural validation of the Chinese version of the 10-item Social Provisions Scale (C-SPS-10) in Chinese populations. Study 1 examined the factor structure, internal reliability, discrimination, criterion validity, and network structure of C-SPS-10 by utilizing a sample of disaster victims in the 2021 Henan floods. Study 2 substantiated the findings of Study 1 in a general population sample. Measurement invariances between populations and between sexes in terms of the C-SPS-10 were also tested using the network approach. Study 3 used three samples to examine the test-retest reliability of the C-SPS-10 over three different time periods. The general results showed that the C-SPS-10 has excellent factor structure, internal reliability, discrimination, and criterion validity. The C-SPS-10 was confirmed to have good psychometric properties. Although the full scale functions well, problems may exist at a domain level. Moreover, the full scale of the C-SPS-10 was varied as a useful tool to capture trait-like characteristics of individuals' perceptions of social support for the general population. Supplementary Information: The online version contains supplementary material available at 10.1007/s10862-023-10047-7.

Anastomosis Groups and Mycovirome of Rhizoctonia Isolates Causing Sugar Beet Root and Crown Rot and Their Sensitivity to Flutolanil, Thifluzamide, and Pencycuron.

Anastomosis groups (AGs) or subgroups of 244 Rhizoctonia isolates recovered from sugar beet roots with symptoms of root and crown rot were characterized to be AG-A, AG-K, AG-2-2IIIB, AG-2-2IV, AG-3 PT, AG-4HGI, AG-4HGII, and AG-4HGIII, with AG-4HGI (108 isolates, 44.26%) and AG-2-2IIIB (107 isolates, 43.85%) being predominate. Four unclassified mycoviruses and one hundred and one putative mycoviruses belonging to six families, namely Mitoviridae (60.00%), Narnaviridae (18.10%), Partitiviridae (7.62%), Benyviridae (4.76%), Hypoviridae (3.81%), and Botourmiaviridae (1.90%), were found to be present in these 244 Rhizoctonia isolates, most of which (88.57%) contained positive single-stranded RNA genome. The 244 Rhizoctonia isolates were all sensitive to flutolanil and thifluzamide, with average median effective concentration (EC50) value of 0.3199 ± 0.0149 µg·mL-1 and 0.1081 ± 0.0044 µg·mL-1, respectively. Among the 244 isolates, except for 20 Rhizoctonia isolates (seven isolates of AG-A and AG-K, one isolate of AG-4HGI, and 12 isolates of AG-4HGII), 117 isolates of AG-2-2IIIB, AG-2-2IV, AG-3 PT, and AG-4HGIII, 107 isolates of AG-4HGI, and six isolates of AG-4HGII were sensitive to pencycuron, with average EC50 value of 0.0339 ± 0.0012 µg·mL-1. Correlation index (ρ) of cross-resistance level between flutolanil and thifluzamide, flutolanil and pencycuron, and thifluzamide and pencycuron was 0.398, 0.315, and 0.125, respectively. This is the first detailed study on AG identification, mycovirome analysis, and sensitivity to flutolanil, thifluzamide, and pencycuron of Rhizoctonia isolates associated with sugar beet root and crown rot.

NGCICM: A Novel Deep Learning-Based Method for Predicting circRNA-miRNA Interactions.

The circRNAs and miRNAs play an important role in the development of human diseases, and they can be widely used as biomarkers of diseases for disease diagnosis. In particular, circRNAs can act as sponge adsorbers for miRNAs and act together in certain diseases. However, the associations between the vast majority of circRNAs and diseases and between miRNAs and diseases remain unclear. Computational-based approaches are urgently needed to discover the unknown interactions between circRNAs and miRNAs. In this paper, we propose a novel deep learning algorithm based on Node2vec and Graph ATtention network (GAT), Conditional Random Field (CRF) layer and Inductive Matrix Completion (IMC) to predict circRNAs and miRNAs interactions (NGCICM). We construct a GAT-based encoder for deep feature learning by fusing the talking-heads attention mechanism and the CRF layer. The IMC-based decoder is also constructed to obtain interaction scores. The Area Under the receiver operating characteristic Curve (AUC) of the NGCICM method is 0.9697, 0.9932 and 0.9980, and the Area Under the Precision-Recall curve (AUPR) is 0.9671, 0.9935 and 0.9981, respectively, using 2-fold, 5-fold and 10-fold Cross-Validation (CV) as the benchmark. The experimental results confirm the effectiveness of the NGCICM algorithm in predicting the interactions between circRNAs and miRNAs.

Separation and Analysis of Oxygen-Containing Compounds in a Shaanxi Middle/Low-Temperature Coal Tar.

A middle/low-temperature coal tar (M/LTCT) was obtained from a low-temperature carbonization plant in Shaanxi, China. The M/LTCT was separated into light components and coal tar pitch through extraction. A series of alkanes, aromatic hydrocarbons, oxygen-containing arenes (OCAs), and nitrogen-containing arenes were fractionated from light components by medium-pressure preparative chromatography with gradient elution using petroleum ether and ethyl acetate. They were analyzed using a gas chromatography-mass spectrometer (GC-MS) and a Fourier transform infrared spectrometer. The OCAs were analyzed by a Fourier transform Orbitrap MS (quadrupole exactive Orbitrap mass spectrometer), and the molecular distribution of the O 1-O 6 species was studied. OCAs are mainly oxygen-containing aromatic compounds, including aromatic phenols, furans, alkoxy aromatic hydrocarbons, aromatic ethers, aromatic aldehydes, aromatic ketones, and aromatic acids. The position of the oxygen atom on the aromatic ring and the condensation form of the aromatic ring are studied.

Experimental and Kinetic Study of the Effect of Nitrogen Dioxide on Ethanol Autoignition.

The contribution of NO2 to the ethanol ignition delay time was investigated behind reflected shock waves. The experiments were performed at a pressure of 0.20 MPa, temperature range of 1050-1650 K, equivalence ratio of 0.5/1.0/1.5, and ethanol/NO2 mixing ratios of 100/0, 90/10, and 50/50. The experimental results showed that the addition of NO2 decreased the ignition delay time and promoted the reactivity of ethanol under all equivalence ratios. With an increase in NO2 blending, the effect of equivalence ratio on the ethanol ignition delay time decreased, and with an increase in temperature, the effect of NO2 in promoting ethanol ignition weakened. An updated mechanism was proposed to quantify NO2-promoted ethanol ignition. The mechanism was validated based on available experimental data, and the results were in line with the experimental trends under all conditions. Chemical kinetic analyses were performed to interpret the interactions between NO2 and ethanol for fuel ignition. The numerical analysis indicated that the promotion effect of NO2 is primarily due to an increase of the rate of production and concentration of the radical pool, especially the OH radical pool. The reaction NO + HO2 ⇔ NO2 + OH is key to generating chain-initiating OH radicals.

Dynamic structure of posttraumatic growth among victims of the 2021 Henan floods: A 6-month, three-wave longitudinal study.

Posttraumatic growth (PTG) following traumatic events is a dynamic and transformational process. However, its dynamic structure is currently unknown. The study aimed to estimate the dynamic structure of PTG at the nuance level based on PTG measurement items using network analysis. A three-wave longitudinal study was conducted from July 20, 2021, to January 30, 2022, among the victims experiencing the 2021 Henan floods. The final sample (n = 297) completed reports of PTG after 0, 3, and 6 months of the disaster. We employed the graphical vector autoregressive model approach to estimate extended network models. Contemporaneous network results revealed strong positive associations between domains of PTG in the same measurement window, especially between new possibilities and personal strength. Moreover, temporal network results-the internal interplays among PTG items across measurement windows-revealed that the domain of relating to others plays a central role in the dynamics of PTG. Although other domains predicted an increase in relating to others, relating to others inhibited the development of other domains, especially new possibilities and personal strength. Our study identifies the culture-specific process of PTG and provides empirical evidence on the explanatory models of PTG and the Janus-Face model of PTG.

Associations between sex differences, eating disorder behaviors, physical and mental health, and self-harm among Chinese adolescents.

BACKGROUND AND AIM: Eating Disorders (ED) result in impaired well-being, but there exist an insufficient number of studies that have focused on the influence of sex and sexual orientation disparities within ED behaviors. Thus, we aimed to investigate ED behaviors among male and female adolescents with different sexual orientations in a school sample to understand prevalence and correlates of different ED behaviors. METHOD: Data was analysed from 11,440 Chinese school adolescents with a mean age of 14.74 years (SD = 1.46). Reported data was gathered on sociodemographic information including sexual orientation, ED behaviors, health factors (reported health, cognitive function), mental health factors (depression, anxiety, suicidal ideation, non-suicidal self-injurious behavior), and social functioning (school bully victimization, and school bully perpetration). Logistic regression models were used to estimate the associations with ED behaviors, using the heterosexual orientation as the reference group as they are the majority. RESULTS: Compared to female adolescents, male adolescents reported lower anxiety symptoms (t = - 12.39, p < 0.001, Cohen's d = - 0.233), were more likely to be the perpetrator of school bullying (χ2 = 190.61, p < 0.001, φ = 0.129), and reported a lower likelihood of taking dietary restriction (χ2 = 290.08, p < 0.001, φ = 0.160). Overall, the prevalence of dietary restriction presented sex disparities. Adolescents who reported no sexual attraction were less likely to engage in ED behaviors. Using heterosexual orientation as the reference group, the group who reported no sexual attraction was associated with lower risk in dietary restriction and purging in both male and female adolescents. Using the heterosexual orientation as the reference group, female sexual minority groups were at high risk of ED behaviors, with bisexual orientation and gay/lesbian orientation having a higher likelihood of engaging in objective binge eating. CONCLUSIONS: The results revealed significant sex and sexual orientation differences of ED behaviors. The study suggests that adolescents is a period of sexuality development and could be critical for understanding adolescents' eating behaviors. It is important to guide adolescents to healthy eating during their development and considerations should be made by clinicians when creating interventions for ED behaviors among the different sex and sexual orientation groups.