Evaluación antropométrica de celíacos adultos de la Comunidad Valenciana / Anthropometric evaluation of adult coeliac patients from de Valencian Community (Spain)

Introducción: El objetivo de este trabajo es evaluar el estado nutricional de un grupo de pacientes celíacos de la Comunidad Valenciana a través de sus características antropométricas. Se diseñó un estudio transversal en el cual todos los pacientes llevaban más de seis meses en tratamiento con dieta sin gluten (DSG). Material y métodos: El universo muestral lo constituyeron 2000 asociados de la Asociación de Celíacos de la Comunidad Valenciana (ACECOVA) de ambos sexos y diferentes rangos de edad a los que invitó a participar. Se incluyeron las tres provincias, Castellón, Valencia y Alicante. Finalmente, se evaluaron los datos antropométricos de 139 sujetos celíacos entre adultos y niños. De los 84 adultos, el 77,4% fueron mujeres. Todos los participantes fueron citados para medir su peso y altura en el laboratorio de antropometrías de la Facultat de Farmàcia de la Universitat de València. Se seleccionaron las siguientes medidas antropométricas: peso corporal, talla e índice de masa corporal (IMC) y percentil de peso y de altura. Resultados: El 12% de la población celíaca adulta presenta sobrepeso y el 5% obesidad, proporciones mucho menores que en la población española en general y en la valenciana en particular. Sin embargo, las proporciones de peso insuficiente en el 9% de los celíacos y de normopeso en el 74% superan las de la población sana. Conclusiones: Habría que investigar el cumplimiento de la DSG en celíacos tratados con el fin de obtener menores proporciones de peso insuficiente que pueden relacionarse con desnutrición (AU)

Introduction: The objective of this work is to evaluate the nutritional status of a group of celiac patients from the Valencian Community through their anthropometric characteristics. A cross-sectional study was designed, in which all patients followed a iet without gluten during at least six months. Material and methods: The sample was constituted by 2000 members of the Association of Celiacs of the Valencian Community (ACECOVA) of both sexes and different age ranges were passed to the questionnaires. The three provinces, Castellón, Valencia and Alicante were included. Finally, anthropometric data of 139 people with celiac disease were evaluated, between adults and children. Among the 84 adults, 77.4% were women. All participants were summoned to measure their weight and height in the laboratory of Anthropometries of the Faculty of Pharmacy of the University of Valencia. The following anthropometric measures were selected: body weight, height and body mass index. Results: 12% of the adult celiac population presents overweight and 5% obesity, much smaller proportions than in the general population and in the Valencian Spanish in particular. However, the proportions of underweight in 9% of celiac patients and normal weight in 74% surpass those of the healthy population. Conclusions: Further investigation should be carried out about the compliance of the diet without gluten in gluten-free diets in order to obtain lower proportions of underweight, may be related to malnutrition (AU)

Evaluación del estado de salud en celíacos adultos de la Comunidad Valenciana / Evaluation of the health status in adult celiacs of the Valencian Community

Introducción: En algunos estudios se ha encontrado que, con los años, además de aumentar la grasa corporal se redistribuye de manera desfavorable para la salud del adulto mayor, aumenta la cantidad de tejido adiposo en la parte central del cuerpo, lo cual puede ser un importante factor de riesgo para el desarrollo de enfermedades crónicas como la Diabetes Mellitus. Como objetivo se evaluó el estado nutricional de los centenarios diabéticos y no diabéticos así como se exploraron las variaciones de indicadores antropométricos. Métodos: Se realizó un estudio analítico de casos y controles escogidos de forma aleatoria. Se estudiaron un total de 70 centenarios de La Habana, 35 diabéticos y 35 controles no diabéticos, a los cuales se les calculó el índice de masa corporal, circunferencias del brazo y pierna. Se calcularon las frecuencias absolutas y los porcentajes así como medias de desviación estándar para las variables cuantitativas. Resultados: En ambos grupos predominaron las mujeres con respecto a los hombres, se distribuyeron según la edad entre los 100 y 104 años, tanto los centenarios diabéticos como los no diabéticos tenían, en el 2010, un estado nutricional normal de acuerdo al IMC y a la circunferencia braquial, no así para la circunferencia de la pantorrilla que evidenció desnutrición en ambos grupos. Conclusiones: El estado nutricional de los centenarios diabéticos y no diabéticos fue aceptable en cuanto al Índice de Masa Corporal y a la circunferencia braquial, no así en cuanto a la circunferencia de la pantorrilla donde se evidenció desnutrición (AU)

Background: Some studies have found that, over the years, in addition to increasing body fat is redistributed unfavorable to the health of the elderly way, the amount of adipose tissue in the center of the body, which can be an important risk factor for the development of chronic diseases such as Diabetes Mellitus. The target was the nutritional status of centenarians assessed diabetic and not diabetic and changes in anthropometric indicators were explored. Methods: An analytical study of cases and randomly selected controls were performed. A total of 70 centenarians Havana, 35 diabetic and 35 nondiabetic controls, which were calculated the body mass index, arm and leg were studied. Absolute frequencies and percentages as well as mean standard deviation for quantitative variables were calculated. Results: In both groups predominated women compared to men, were distributed by age between 100 and 104 years, both diabetics ancient and non-diabetics had, in 2010, a normal nutritional status according to BMI and brachial circumference, but not for the calf circumference showed malnutrition in both groups. Conclusions: Nutritional status of diabetic and nondiabetic centenarian was acceptable in terms of body mass index and arm circumference, but not in terms of calf circumference where malnutrition was evident (AU)

[Quality of life and diagnosis process in adult celiacs from the Valencian Community]. / Calidad de vida y proceso diagnóstico en celíacos adultos de la Comunidad Valenciana.

INTRODUCTION: In adult patients, the diagnostic process for celiac disease (CD) is often very late and generates health complications that would be avoided by earlier diagnosis. The diseases of wich these patients were diagnosed before setting the diagnosis of CD were many and diverse. In addition, following a gluten-free diet (GFD) leads to a reduction in the quality of life for patients, who find it difficult to travel, to find accredited restaurants with menus without gluten, to interpretate food labels or to go to friends' houses. OBJECTIVE: To determine the delay in diagnosis, the satisfaction of the information provided by different sources and circumstances related to the quality of life. METHOD: A retrospective cross-sectional observational study in 98 adult celiac through a validated questionnaire for celiac patientes. RESULTS: The average delay in diagnosis was 11 years and the average of doctors consulted prior to confirmation of the CD was 6. Osteoporosis or osteopenia were nearly twice as common among those who took more than five years to be diagnosed. Some 90% say they transgress the dietary pattern, however, 58% show clinical symptoms due to unnoticed consumption of gluten. The impact of GFD on the quality of life is very high. CONCLUSIONS: Long delays in diagnosis suggest the need for greater awareness among physicians about the EC and the use of serological tests in potential patients or risk groups.

Calidad de vida y proceso diagnóstico en celíacos adultos de la Comunidad Valenciana / Quality of life and diagnosis process in adult celiacs from the Valencian Community

Introducción: En pacientes adultos, el proceso diagnóstico de la enfermedad celíaca (EC) suele ser muy tardío y genera complicaciones de salud que se evitarían con un diagnóstico más temprano. Las enfermedades de las que se diagnosticó a estos pacientes antes de sentarse el diagnóstico de EC fueron muchas y diversas. Además, el seguimiento de la dieta sin gluten (DSG) comporta una merma en la calidad de vida de los pacientes, que encuentran dificultades para viajar, encontrar restaurantes acreditados con menús sin gluten, interpretar las etiquetas de los alimentos o salir a casas de amigos. Objetivo: Determinar el retraso en el diagnóstico, la satisfacción de la información aportada por las distintas fuentes y circunstancias relacionadas con la calidad de vida. Método: Estudio observacional transversal retrospectivo en 98 celíacos adultos mediante un cuestionario validado para celíacos. Resultados: El retraso medio en el diagnóstico fue de once años y la media de médicos consultados antes de confirmarse la EC fue de seis. La osteoporosis u osteopenia fueron casi dos veces más frecuentes entre los que tardaron más de cinco años en ser diagnosticados. El 90% afirma no transgredir la pauta dietética; sin embargo, el 58% presenta sintomatología clínica debida al consumo inadvertido de gluten. El impacto de la DSG sobre la calidad de vida es muy alto. Conclusiones: Los largos retrasos en el diagnóstico sugieren la necesidad de una mayor concienciación entre los médicos sobre la EC y la utilización de tests serológicos en pacientes potenciales o en grupos de riesgo (AU)

Introduction: In adult patients, the diagnostic process for celiac disease (CD) is often very late and generates health complications that would be avoided by earlier diagnosis. The diseases of wich these patients were diagnosed before setting the diagnosis of CD were many and diverse. In addition, following a glutenfree diet (GFD) leads to a reduction in the quality of life for patients, who find it difficult to travel, to find accredited restaurants with menus without gluten, to interpretate food labels or to go to friends' houses. Objective: To determine the delay in diagnosis, the satisfaction of the information provided by different sources and circumstances related to the quality of life. Method: A retrospective crosssectional observational study in 98 adult celiac through a validated questionnaire for celiac patientes. Results: The average delay in diagnosis was 11 years and the average of doctors consulted prior to confirmation of the CD was 6. Osteoporosis or osteopenia were nearly twice as common among those who took more than five years to be diagnosed. Some 90% say they transgress the dietary pattern, however, 58% show clinical symptoms due to unnoticed consumption of gluten. The impact of GFD on the quality of life is very high. Conclusions: Long delays in diagnosis suggest the need for greater awareness among physicians about the EC and the use of serological tests in potential patients or risk groups (AU)

Spectrophotometric determination of dihydralazine in pharmaceuticals after derivatization with 2-hydroxy-1-naphthaldehyde.

A sensitive and selective colorimetric assay has been developed for the determination of dihydralazine. The method is based on the interaction of dihydralazine with an ethanolic solution of 2-hydroxy-1-naphthaldehyde to yield a water-insoluble yellow product, 1,4-bis[(2-hydroxy-1-naphthyl)methylene hydrazine]phthazine. This colour can be quantified spectrophotometrically at 420 nm. The calibration curve was linear between 0.4 and 8 micrograms ml-1 of dihydralazine. The molar absorptivity at 420 nm is 24000 l mol-1 cm-1. The method was successfully applied to the determination of dihydralazine in mixtures containing other drugs (reserpine, hydrochlorothiazide, oxprenolol, xanthinol, rutoside, chlorthalidone and bietaserpine).

Spectrophotometric determination of hydralazine with 2-hydroxy-1-naphthaldehyde in pharmaceuticals.

A new extraction-spectrophotometric method for the determination of hydralazine, based on its reaction with 2-hydroxy-1-naphthaldehyde at 25 degrees C, is described. The calibration curve was linear between 0.4 and 6 mg/mL of hydralazine. The molar absorbtivity of the product at 408 nm is 40,900 L.mol-1.cm-1. The method described was applied to the analysis of hydralazine in pharmaceutical preparations containing reserpine, hydrochlorothiazide, bendrofluorthiazine, propranolol, and other substances. The agreement with the U.S.P. XXI method was satisfactory for tablets and injections, but not for pellets.

Atmospheric contamination in the city of Valencia: relation to noise and climate.

A qualitative and quantitative study is made of the polycyclic aromatic hydrocarbons (PAH), nitrogen oxide, and sulfur dioxide in the atmosphere of the city of Valencia for the period 1988-1989; an analysis is made of their concentrations during the year in terms of season and noise levels. Eleven sampling points in the city were used to determine PAH composition by reverse-phase, high-resolution liquid chromatography with fluorimetric detection, employing an acetonitrile-water gradient; nitrogen oxides and sulfur dioxide were determined by the Valencia city government. Environmental noise levels were determined using a BK 2221 integrated precision sonometer, and temperature values were obtained from the city Meteorological Institute. Daily PAH values varied between 0.1769 and 2.0916 micrograms/m3, whereas the figures for nitrogen oxide were between 91.5 and 100.67 micrograms/m3 during 1982-1989 (only one value, 58.01 micrograms/m3, is available for 1988-1989, corresponding to the Mercadona sampling point), and between 17.33 and 129.36 micrograms/m3 for sulfur dioxide for a total of 9 sampling points; the highest concentrations were recorded in the winter and spring months, the association between PAH and temperature being statistically significant (p less than or equal to .05). The relation to noise was also significant (p less than or equal to .005), Fluoranthene was the predominant PAH in all samples analyzed.