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Article in English | MEDLINE | ID: mdl-21530211

ABSTRACT

The proinflammatory leukotriene B4 (LTB4) may be of importance in the progression of chronic kidney disease (CKD). We investigated whether n-3 polyunsaturated fatty acids (PUFA) decrease LTB4 and increase the formation of the less inflammatory leukotriene B5 (LTB5) in patients with CKD. Fifty-six patients with CKD stage 2-5 were randomised to 2.4 g n-3 PUFA or olive oil for 8 weeks. Compared to controls, n-3 PUFA significantly decreased release of LTB4 (p<0.001) and 5-hydroxyeicosatetraenoic acid (5-HETE) (p<0.01) and significantly increased release of LTB5 (p<0.001) and 5-hydroxyeicosapentaenoic acid (5-HEPE) (p<0.001) from stimulated neutrophil granulocytes. Kidney function evaluated by creatinine clearance and proteinuria did not improve. In conclusion, n-3 PUFA supplementation for 8 weeks in patients with CKD stage 2-5 significantly decreased LTB4 and 5-HETE and significantly increased LTB5 and 5-HEPE. No effect was seen on kidney function.


Subject(s)
Dietary Supplements , Eicosapentaenoic Acid/analogs & derivatives , Fatty Acids, Omega-3/therapeutic use , Leukotriene B4/analogs & derivatives , Leukotriene B4/metabolism , Neutrophil Activation , Neutrophils/metabolism , Renal Insufficiency, Chronic/diet therapy , Dietary Supplements/adverse effects , Double-Blind Method , Down-Regulation , Eicosapentaenoic Acid/metabolism , Fatty Acids/analysis , Fatty Acids/blood , Fatty Acids, Omega-3/adverse effects , Fatty Acids, Omega-3/analysis , Female , Fish Oils/adverse effects , Fish Oils/chemistry , Fish Oils/therapeutic use , Granulocytes/immunology , Granulocytes/metabolism , Humans , Kidney/physiopathology , Male , Middle Aged , Neutrophils/immunology , Patient Dropouts , Renal Insufficiency, Chronic/immunology , Renal Insufficiency, Chronic/physiopathology , Severity of Illness Index , Up-Regulation
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