ABSTRACT
OBJECTIVE: The aim of this exploratory study was to analyze the urinary excretion of Clara cell protein (CC16), a new marker of proximal tubular dysfunction (PTD), in kidney transplantation (KT). MATERIALS AND METHODS: Urinary concentrations of CC16, ß2-microglobulin (ß2m), and N-acetyl-glucosaminidase (NAG) were measured in 50 KT patients (72% men; mean age 50.4 ± 12.4 years; diabetes in 24%; duration of KT 4.3 ± 3.1 years) and 10 healthy controls (6 men; mean age 33.6 ± 13.4 years). RESULTS: Urinary levels of ß2m, NAG, and CC16 were significantly higher in KT patients than in controls: ß2m: 0.77 (interquartile range [IQ] 0.22 to 4.62) g/g vs 0.069 (IQ 0.05 to 0.10) g/g; NAG: 3.16 (IQ 2.09 to 5.33) U/g vs 1.73 (IQ 1.25 to 2.07) U/g; CC16: 26.01 (IQ 8.62 to 123.3) g/g vs 2.51 (IQ 0.83 to 7.18) g/g (P < .001). Elevated levels of ß2m, NAG, and CC16 were found in 81%, 28%, and 71% of KT patients, respectively. Urinary levels of ß2m, NAG, and CC16 significantly increase as glomerular filtration rate (GFR) decreases. Interestingly, in patients with GFR >60 mL/min, we still found high levels of ß2m, NAG, and CC16 in 77%, 13%, and 52%, respectively. Diabetic subjects had significant higher levels of the 3 markers compared with nondiabetic subjects, without differences in albumin excretion or GFR. CC16 showed a positive correlation with urinary albumin (r = 0.42, P < .001), NAG (r = 0.352, P < .05), and ß2m (r = 0.75, P < .001). CONCLUSION: PTD is highly prevalent in KT patients. This is the first study that analyzes CC16 in KT patients, showing that the urinary excretion of this protein is significantly increased in this population. Further studies are needed to examine the clinical value of CC16 in KT patients.
Subject(s)
Fanconi Syndrome/urine , Kidney Transplantation/adverse effects , Postoperative Complications/urine , Uteroglobin/urine , Acetylglucosaminidase/urine , Adult , Albuminuria/urine , Biomarkers/urine , Case-Control Studies , Diabetes Mellitus/urine , Fanconi Syndrome/etiology , Female , Glomerular Filtration Rate , Humans , Male , Middle Aged , Postoperative Complications/etiology , Postoperative Period , Risk Factors , beta 2-Microglobulin/urineSubject(s)
Diabetic Nephropathies/complications , Diabetic Nephropathies/physiopathology , Biopsy , Diabetes Mellitus, Type 2/complications , Diabetic Nephropathies/blood , Diabetic Nephropathies/pathology , Disease Progression , Glomerular Filtration Rate , Humans , Hyperglycemia/complications , Kidney/pathology , Nitric Oxide/physiology , Risk FactorsABSTRACT
Cases of poisoning with pesticides, especially suicidal ones, continue to be an important therapeutic problem. The heribicide paraquat (1.1' dimethyl-4.4' bipyridylium dichloride) is the second cause of pesticide poisoning in our country, which is associated with a high mortality rate. We report two cases of suicidal ingestion of paraquat who developed multiorgan failure with a lethal outcome. We also present a brief review of the literature, mainly focused on the different therapeutic options.
Subject(s)
Paraquat/poisoning , Adult , Humans , Male , Middle Aged , SuicideABSTRACT
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Subject(s)
Humans , Diabetic Nephropathies/blood , Diabetic Nephropathies/complications , Diabetic Nephropathies/pathology , Diabetic Nephropathies/physiopathology , Hyperglycemia/complications , Biopsy , Diabetes Mellitus, Type 2/complications , Disease Progression , Glomerular Filtration Rate , Kidney/pathology , Nitric Oxide/physiology , Risk FactorsABSTRACT
A case of acute oliguric renal failure secondary to poisoning by acetic acid (AA) is described. The patient presents caustic damage in the mucous digestive, myoglobinuria, thrombopaenia, elevation of the enzymes of damage tissular and acute hepatic affectation. To the entrance, the patient show a good hemodynamic state and the hematologic study discarded the hemolysis presence, what allowed to establish the direct action of the AA on the kidney like cause of the oliguric failure renal next to the tubular toxic effect of the myoglobin. The oral ingesta of AA is an unusual fact and its relationship with the acute renal failure it has not been communicated previously in our country.
Subject(s)
Acetic Acid/poisoning , Acute Kidney Injury/chemically induced , Oliguria/chemically induced , Acute Kidney Injury/diagnosis , Adult , Esophageal Stenosis/chemically induced , Esophageal Stenosis/diagnosis , Esophagitis/chemically induced , Gastritis/chemically induced , Humans , Male , Oliguria/diagnosis , Poisoning/complications , Poisoning/diagnosis , Suicide, AttemptedABSTRACT
Se describe un caso de fracaso renal agudo oligúrico secundario a intoxicación por Ácido Acético (AA). El paciente presentó daño cáustico en la mucosa digestiva, mioglobinuria, trombopenia, elevación de las enzimas de daño tisular y afectación hepática aguda. Al ingreso, el paciente evidenció un buen estado hemodinámico y el estudio hematológico descartó la presencia de hemólisis, lo que permitió establecer la acción directa del AA sobre el riñón como causa del fracaso renal oligúrico junto al efecto tóxico tubular de la mioglobina. La ingesta oral de AA es un hecho inusual y su relación con el fracaso renal agudo no ha sido comunicado con anterioridad en nuestro país (AU)
Subject(s)
Adult , Male , Humans , Acetic Acid , Esophageal Stenosis/chemically induced , Esophageal Stenosis/diagnosis , Esophagitis/chemically induced , Gastritis/chemically induced , Acute Kidney Injury/diagnosis , Oliguria/diagnosis , Poisoning/complications , Poisoning/diagnosis , Suicide, Attempted , Acetic Acid/poisoning , Acute Kidney Injury/chemically induced , Oliguria/chemically inducedABSTRACT
Five patients with idiopathic interstitial nephritis and uveitis without bone marrow granulomas were followed-up for 1 year. Ophthalmological examination revealed bilateral anterior uveitis. Light microscopy of the renal tissue revealed predominant lymphocyte infiltration of the interstitium. Immunohistochemical analysis revealed a clear predominance of memory T lymphocytes (CD45RO+) in the interstitial and tubular infiltration. HLA typing, and immunophenotypic studies of peripheral blood mononuclear cells including absolute lymphocyte and monocyte counts were assessed. The patients' peripheral T-cell subpopulation did not significantly differ from control studies. With steroid treatment maintained during a period of 6-9 months renal function and uveitis responded dramatically in all patients. After 1-year follow-up, only 1 patient showed a relapse of uveitis, but there was complete clinical recovery of the nephritis in all 5 patients. The aim of this study was to describe the 1-year follow-up of 5 new cases of acute tubulointerstitial nephritis and uveitis syndrome, and assess some aspects of their cellular immunity.
