Description and clinical studies of a device for the instantaneous detection of office-place stress.

Occupational stress is universally experienced and is emerging as a major risk factor for physical and mental illness and a key factor in poor work performance and low job satisfaction. However, the technology does not currently exist to unobtrusively measure occupational stress in real-time. Here, we describe the design and clinical validation of an automated high-definition thermal imaging system that can be used to quantify human stress, remotely and instantaneously. Healthy human subjects underwent a computer-based version of the Stroop-color conflict test, which is a validated stress provocation test, in an experimental office facility. In separate experiments, the same subjects completed a mental arithmetic challenge. The thermal signal associated with stress provocation is near-instantaneous corrugator warming. The stress response was detected in all subjects for all stress-events compared to the respective baselines. Furthermore, there was remarkable inter-individual preservation of the corrugator signal with stress R(2) = 0.96, P< 0.001). High-definition thermal imaging can be used for real-time detection of stress provocation. This technology may prove to be of help in ameliorating office-place stress.

Sex differences in vascular and endothelial responses to acute mental stress.

OBJECTIVE: Our objective was to assess the differences in systemic vascular and endothelial function in response to acute mental stress between men and women. The endothelium plays a pivotal role in vascular homeostasis and the development of atherosclerotic heart disease. The mechanism and presentation of cardiovascular events show a sex-based difference, although the sex difference in the vascular and endothelial response to mental stress is not known. METHODS: Male (n = 34) and female (n = 53) subjects participated in a series of three different mental stress tasks during which vascular response was measured non-invasively using peripheral arterial tonometry. Endothelial function was assessed using reactive hyperemia peripheral arterial tonometry. Double product (systolic blood pressure x heart rate) was calculated. RESULTS: Males had a greater double product response (27.2 + 3.6% increase in double product vs. 19.2 + 1.7%; P = 0.01), and a greater vascular reactivity to mental stress. Females demonstrated a reduced response to reactive hyperemia (-0.47 vs. 13.74%; P = 0.01). Furthermore, a subgroup of females who showed the least vaso-reactivity to mental stress showed the greatest decline in endothelial function (-10.5 + 4% vs. 17.4 + 6.3%; P < 0.001). INTERPRETATION: This study demonstrates sex-based differences in the vascular and endothelial responses to mental stress. The mental stress-induced reduction in endothelial function and increased double product seen in the females might manifest clinically as contributing to the pathophysiology of mental stress-mediated cardiovascular events in female patients and provide further information regarding the potential mechanism for sex differences in cardiac events.

Does Non-Exercise Activity Thermogenesis Contribute to Non-Shivering Thermogenesis?

We wanted to examine if spontaneous physical activity contributes to non-shivering thermogenesis. Ten lean, healthy male subjects wore a physical activity, micro-measurement system whilst the room temperature was randomly altered at two hourly intervals between thermoneutral (72°F), cool (62°F) and warm (82°F) temperatures. Physical activity measured during the thermoneutral, cooling and warming periods was not significantly different. Cooling, increased EE above basal and thermoneutral values 2061 ± 344 kcal/day (p <0.01). Thus, the increase in energy expenditure associated with short-term environmental cooling in lean, healthy males does not appear to be due to increased spontaneous physical activity or fidgeting.