Your browser doesn't support javascript.
loading
Show: 20 | 50 | 100
Results 1 - 3 de 3
Filter
Add more filters










Database
Language
Publication year range
1.
Emerg Infect Dis ; 12(8): 1242-4, 2006 Aug.
Article in English | MEDLINE | ID: mdl-16965704

ABSTRACT

We investigated a cluster of blastomycosis in 8 humans and 4 dogs in a rural North Carolina community. Delayed diagnosis, difficulty isolating Blastomyces dermatitidis in nature, and lack of a sensitive and specific test to assess exposure make outbreaks of this disease difficult to study.


Subject(s)
Blastomyces/isolation & purification , Blastomycosis/epidemiology , Disease Outbreaks , Dog Diseases/epidemiology , Lung Diseases, Fungal/epidemiology , Adolescent , Adult , Aged , Aged, 80 and over , Animals , Blastomycosis/microbiology , Blastomycosis/physiopathology , Dog Diseases/microbiology , Dogs , Female , Humans , Lung Diseases, Fungal/microbiology , Lung Diseases, Fungal/physiopathology , Male , Middle Aged , North Carolina/epidemiology , Rural Population
2.
Clin Infect Dis ; 40(5): 677-82, 2005 Mar 01.
Article in English | MEDLINE | ID: mdl-15714412

ABSTRACT

BACKGROUND: In 2000, an outbreak of listeriosis among Hispanic persons was identified in Winston-Salem, North Carolina. The objectives of the present study were to identify the source of, strains associated with, and risk factors for Listeria monocytogenes infection for patients affected by the outbreak. METHODS: Microbiological, case-control, and environmental investigations were conducted. Participants in the case-control study were case patients who became infected with L. monocytogenes between 1 October 2000 and 31 January 2001 and control subjects who were matched with case patients on the basis of ethnicity, sex, age, and pregnancy status. All participants were residents of Winston-Salem. RESULTS: We identified 13 patients, all of whom were Hispanic, including 12 females who were 18-38 years of age. Eleven case patients were pregnant; infection with L. monocytogenes resulted in 5 stillbirths, 3 premature deliveries, and 3 infected newborns. Case patients were more likely than control subjects to have eaten the following foods: fresh, unlabeled, Mexican-style cheese sold by door-to-door vendors (matched odds ratio [MOR], 17.5; 95% confidence interval [CI], 2.0-152.5); queso fresco, a Mexican-style soft cheese (MOR, 7.3; 95% CI, 1.4-37.5); and hot dogs (MOR, 4.6; 95% CI, 1.1-19.4). L. monocytogenes isolates recovered from 10 female case patients, from cheese bought from a door-to-door vendor, from unlabeled cheese from 2 Hispanic markets, and from raw milk from a local dairy had indistinguishable patterns on pulsed-field gel electrophoresis. CONCLUSIONS: This outbreak of listeriosis was caused by noncommercial, fresh, Mexican-style cheese made from contaminated raw milk traced to 1 local dairy. We recommend educating Hispanic women about food safety while they are pregnant, enforcing laws that regulate the sale of raw milk and dairy products made by unlicensed manufacturers, making listeriosis a reportable disease in all states, routinely interviewing case patients, and routinely subtyping clinical L. monocytogenes isolates.


Subject(s)
Cheese/microbiology , Food Microbiology/standards , Foodborne Diseases/epidemiology , Listeriosis/epidemiology , Adolescent , Adult , Aged , Case-Control Studies , Disease Outbreaks , Emigration and Immigration , Female , Humans , Male , Mexico , North Carolina/epidemiology
3.
Am J Trop Med Hyg ; 69(5): 509-18, 2003 Nov.
Article in English | MEDLINE | ID: mdl-14695088

ABSTRACT

La Crosse encephalitis (LACE), a human illness caused by a mosquito-transmitted virus, is endemic in western North Carolina. To assess the economic and social impacts of the illness, 25 serologically confirmed LACE case patients and/or families were interviewed to obtain information on the economic costs and social burden of the disease. The total direct and indirect medical costs associated with LACE over 89.6 life years accumulated from the onset of illness to the date of interview for 24 patients with frank encephalitis totaled dollar 791,374 (range = dollar 7,521-175,586), with a mean +/- SD per patient cost of dollar 32,974 +/- dollar 34,793. The projected cost of a case with lifelong neurologic sequelae ranged from dollar 48,775 to dollar 3,090,798 (n = 5). For the 25 LACE patients, 55.15 (54.83%) of the 100.59 cumulative life years (CLYs) were impaired to some degree. Disability adjusted life years (DALYs) were calculated to measure the productive life years lost to LACE. Approximately 13.00 DALYs were accumulated over 100.59 CLYs of study. Projected DALYs for case patients (n = 5) with lifelong neurologic sequelae ranged from 12.90 to 72.37 DALYs. An Impact of La Crosse Encephalitis Survey (ILCES) was used to measure the social impact of LACE over time for case patients and their families. The ILCES scores demonstrated that the majority of the social burden of the illness is borne by the five patients with lifelong neurologic sequelae. The socioeconomic burden resulting from LACE is substantial, which highlights the importance of the illness in western North Carolina, as well as the need for active surveillance, reporting, and prevention programs for the infection.


Subject(s)
Cost of Illness , Encephalitis, California/economics , Encephalitis, California/epidemiology , La Crosse virus , Adolescent , Adult , Aged , Animals , Child , Culicidae/virology , Encephalitis, California/etiology , Encephalitis, California/pathology , Female , Humans , Insect Vectors/virology , Male , Middle Aged , North Carolina/epidemiology , Severity of Illness Index , Surveys and Questionnaires
SELECTION OF CITATIONS
SEARCH DETAIL
...