ABSTRACT
We report the cytogenetic evaluation of 20 cultured cell strains derived from primary prostatic adenocarcinomas obtained from radical prostatectomies. The majority of the strains contained cells with only normal male karyotypes (46,XY), but cytogenetically abnormal clonal populations were found in five strains. Two of those strains contained aberrations involving the Y chromosome, one with a -Y and one with a +Y. Three strains (one of which also had the XYY karyotype) exhibited cells with double-minute chromosomes and four strains contained near tetraploid cells.
Subject(s)
Adenocarcinoma/genetics , Prostatic Neoplasms/genetics , Sex Chromosome Aberrations , Y Chromosome , Adenocarcinoma/pathology , Chromosome Banding , Humans , Karyotyping , Male , Prostatic Neoplasms/pathology , Tumor Cells, CulturedABSTRACT
A total of 108 male partners of women with cervical condyloma and/or dysplasia underwent evaluation for gross and subclinical condyloma via acetic acid screening with a magnified examination. Biopsies of acetowhite genital skin were obtained for histological and deoxyribonucleic acid hybridization analysis. Of the men 52 (49%) had acetowhite lesions and underwent biopsies, 44 of which were evaluable by histological and deoxyribonucleic acid analyses. Of the lesions 12 had features of condyloma or penile intra-epithelial neoplasia, among which 7 (58%) contained human papillomavirus deoxyribonucleic acid. The remaining 32 lesions revealed minimal histological changes sometimes suggesting condyloma. However, only 5 of the 32 biopsies (16%) contained human papillomavirus deoxyribonucleic acid. A tendency to overdiagnose condyloma based on histological findings is suggested. Criteria by which to identify best human papillomavirus-related morphology are presented. Acetowhite genital epithelia with minor (nonspecific) histological changes correlate poorly with human papillomavirus nucleic acids and in most cases do not represent disease involving common viral types. The application of appropriate histological criteria appears to be particularly relevant to management strategies that avoid overtreatment of minor epithelial abnormalities. It remains unclear whether acetowhite genital epithelia positive for human papillomavirus require treatment given the high tendency for recurrence and lack of demonstrated effect on the natural history of cervical carcinoma.
Subject(s)
Acetates , Condylomata Acuminata/pathology , Penile Neoplasms/pathology , Penis/pathology , Skin/pathology , Acetic Acid , Biopsy , Condylomata Acuminata/diagnosis , Condylomata Acuminata/genetics , DNA Probes, HPV , DNA, Viral/genetics , Humans , Male , Nucleic Acid Hybridization , Penile Neoplasms/diagnosis , Penile Neoplasms/geneticsABSTRACT
We report a case of pure primary testicular carcinoid tumor and review the literature. Distinctions are emphasized among the 3 subgroups of testicular carcinoids and their clinical significance. Criteria to establish the diagnosis of pure primary testicular carcinoid are offered.
Subject(s)
Carcinoid Tumor/pathology , Testicular Neoplasms/pathology , Adult , Carcinoid Tumor/diagnosis , Follow-Up Studies , Humans , Male , Testicular Neoplasms/diagnosis , Testis/pathologyABSTRACT
The ectopic ureter is less common in male than in female patients. It usually terminates proximally to the external sphincter in the seminal vesicle or vas deferens, and usually involves a nonduplicated drainage system of a dysplastic kidney. Men characteristically present with lower tract symptoms, often epididymitis, a cystic or boggy periprostatic mass on rectal examination and ipsilateral nonvisualization on excretory urography. The embryology, pathogenesis, diagnosis and treatment of this condition are discussed, and 4 illustrative cases are presented.
Subject(s)
Choristoma/diagnosis , Genital Neoplasms, Male/diagnosis , Seminal Vesicles , Ureter , Adult , Choristoma/surgery , Genital Neoplasms, Male/surgery , Humans , Kidney/abnormalities , Male , UltrasonographyABSTRACT
A case of extraosseous chondrosarcoma arising from the spermatic cord is reported and the literature reviewed. Chondrosarcoma arising from nonosseous tissue is rare, and only a handful of cases have been reported. However, unlike chondrosarcoma of bone, extraosseous myxoid chondrosarcoma behaves in a less aggressive fashion making the distinction between the two entities prognostically significant.
