1.
Org Lett
; 6(13): 2253-6, 2004 Jun 24.
Article
in English
| MEDLINE
| ID: mdl-15200333
ABSTRACT
[reaction: see text] Asymmetric reduction of ketimines 1 with trichlorosilane can be catalyzed by a new N-methyl L-valine derived Lewis basic organocatalyst, such as 4d, with high enantioselectivity. The structure-reactivity investigation suggests hydrogen bonding and arene-arene interactions between the catalyst and the incoming imine as the main factor determining the enantiofacial selectivity.