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PLoS One ; 15(12): e0241459, 2020.
Article in English | MEDLINE | ID: mdl-33378408

ABSTRACT

OBJECTIVE: The association between vitamin D deficiency and multiple sclerosis (MS) is well described. We set out to use remote sampling to ascertain vitamin D status and vitamin D supplementation in a cross-sectional study of people with MS across the UK. METHODS: People with MS and matched controls were recruited from across the UK. 1768 people with MS enrolled in the study; remote sampling kits were distributed to a subgroup. Dried blood spots (DBS) were used to assess serum 25(OH)D in people with MS and controls. RESULTS: 1768 MS participants completed the questionnaire; 388 MS participants and 309 controls provided biological samples. Serum 25(OH)D was higher in MS than controls (median 71nmol/L vs 49nmol/L). A higher proportion of MS participants than controls supplemented (72% vs 26%, p<0.001); people with MS supplemented at higher vD doses than controls (median 1600 vs 600 IU/day, p<0.001). People with MS who did not supplement had lower serum 25(OH)D levels than non-supplementing controls (median 38 nmol/L vs 44 nmol/L). Participants engaged well with remote sampling. CONCLUSIONS: The UK MS population have higher serum 25(OH)D than controls, mainly as a result of vitamin D supplementation. Remote sampling is a feasible way of carrying out large studies.


Subject(s)
Dietary Supplements , Multiple Sclerosis/blood , Vitamin D Deficiency/blood , Vitamin D/blood , Adult , Aged , Case-Control Studies , Cross-Sectional Studies , Dried Blood Spot Testing , Female , Humans , Male , Middle Aged , Multiple Sclerosis/complications , Multiple Sclerosis/diagnosis , Multiple Sclerosis/diet therapy , Surveys and Questionnaires , United Kingdom , Vitamin D/administration & dosage , Vitamin D Deficiency/complications , Vitamin D Deficiency/diagnosis , Vitamin D Deficiency/diet therapy
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