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J Occup Environ Med ; 56(8): 834-9, 2014 Aug.
Article in English | MEDLINE | ID: mdl-25099409

ABSTRACT

OBJECTIVE: We sought to quantify absorption of triclosan, a potential endocrine disruptor, in health care workers with occupational exposure to soap containing this chemical. METHODS: A cross-sectional convenience sample of two groups of 38 health care workers at separate inpatient medical centers: hospital 1 uses 0.3% triclosan soap in all patient care areas; hospital 2 does not use triclosan-containing products. Additional exposure to triclosan-containing personal care products was assessed through a structured questionnaire. Urine triclosan was quantified and the occupational contribution estimated through regression modeling. RESULTS: Occupational exposure accounted for an incremental triclosan burden of 206 ng/mL (P = 0.02), while triclosan-containing toothpaste use was associated with 146 ng/mL higher levels (P < 0.001). CONCLUSIONS: Use of triclosan-containing antibacterial soaps in health care settings represents a substantial and potentially biologically relevant source of occupational triclosan exposure.


Subject(s)
Anti-Infective Agents, Local/metabolism , Occupational Exposure , Skin Absorption , Soaps/chemistry , Triclosan/metabolism , Adult , Body Burden , Female , Humans , Male , Middle Aged , Toothpastes/chemistry , Triclosan/urine
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