Nanotechnology Integrated Innovative Drug Delivery and Therapy for Cancer.

Cancer remains a significant global health challenge, necessitating innovative approaches to enhance the efficacy and specificity of therapeutic interventions while minimizing adverse effects on healthy tissues. Nanotechnology has emerged as a promising avenue in cancer treatment, offering novel strategies for targeted drug delivery. Nanoparticles, liposomes, and polymer-based systems have played pivotal roles in revolutionizing cancer therapy. Nanotechnology possesses unique physicochemical properties, enabling efficient encapsulation of therapeutic agents and controlled and prolonged release at tumour sites. Advancement in formulations using nanotechnology has made it possible to make multifunctional systems that respond to the microenvironment of a tumour by releasing payloads in response to changes in pH, temperature, or enzymes. Stimuli-responsive polymers can release drugs in response to external cues, enabling site-specific drug release and minimizing systemic exposure. This review explores recent studies and preclinical trials that show how nanoparticles, liposomes, and polymerbased systems could be used to treat cancer, discussing challenges such as scalability, regulatory approval, and potential toxicity concerns along with patents published recently.

Precision Genome Editing Techniques in Gene Therapy: Current State and Future Prospects.

Precision genome editing is a rapidly evolving field in gene therapy, allowing for the precise modification of genetic material. The CRISPR and Cas systems, particularly the CRISPR-- Cas9 system, have revolutionized genetic research and therapeutic development by enabling precise changes like single-nucleotide substitutions, insertions, and deletions. This technology has the potential to correct disease-causing mutations at their source, allowing for the treatment of various genetic diseases. Programmable nucleases like CRISPR-Cas9, transcription activator-like effector nucleases (TALENs), and zinc finger nucleases (ZFNs) can be used to restore normal gene function, paving the way for novel therapeutic interventions. However, challenges, such as off-target effects, unintended modifications, and ethical concerns surrounding germline editing, require careful consideration and mitigation strategies. Researchers are exploring innovative solutions, such as enhanced nucleases, refined delivery methods, and improved bioinformatics tools for predicting and minimizing off-target effects. The prospects of precision genome editing in gene therapy are promising, with continued research and innovation expected to refine existing techniques and uncover new therapeutic applications.

Design and construction of heterostructured Zn2V2O7 cubes and hexagons as an electrode material for high-performance asymmetric supercapacitor applications.

Hierarchical nanostructures have harvested noteworthy attention lately owing to their remarkable capabilities in the fields of energy storing and transformation, catalysis, and electrical devices. We established an effort less and template-free synthetic method to create hierarchical hetero nanostructures of Zn2V2O7, taking into account the benefits of hierarchical nanostructures, we investigated the performance of HNs (Hierarchical Nanostructures) as electrochemical supercapacitors. Electrochemical tests were tested in a 6 M KOH solution to assess their capabilities. The Zn2V2O7 electrode's measured specific capacitance was 750F/g at 1 A/g, with outstanding stability and an excellent retention capacity of 85 % later 5000 cycles in three- electrode electrochemical cells. Asymmetric device such as Zn2V2O7//AC provides a specific capacitance of 76.8F/g at 1 A/g with energy and power densities of 27.3 Wh kg-1 and 800 W kg-1 respectively. The device withstands 85 % of its initial capacity after 5000 continuous GCD cycles at 10 A/g. The outstanding performance observed clearly demonstrates the significant potential and practical utility of Zn2V2O7 in the realm of more efficient energy storage applications.

Activation of Persulfate for Improved Naproxen Degradation Using FeCo2O4@g-C3N4 Heterojunction Photocatalysts.

An effective heterojunction with robust charge separation and enormous degradation efficiency is the major task for photocatalyst preparation. In this study, we have prepared the FeCo2O4-loaded g-C3N4 nanosheet by the sol-gel-assisted calcination method for photo-Fenton-like degradation under visible-light irradiation by activating persulfate. The nanocomposite exhibits a higher charge separation efficiency than pure g-C3N4 and FeCo2O4 for the degradation reaction against naproxen drugs. An effective interaction between the nanoparticles increases the degradation efficiency up to 91% with a synergistic index of 73.62%. Moreover, the nanocomposite exhibits a 78% mineralization efficiency against the naproxen pollutant under visible-light irradiation. For practical implementation, the degradation reaction was tested with various pH values, different water sources (DI, lake, and tap water), and light sources (LED (visible)/direct sunlight (UV-visible)). Moreover, the possible degradation mechanism predicted by the elemental trapping experiment and the recycling experiment clearly revealed that the heterojunction composite has a high enough degradation stability.