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1.
Int J Angiol ; 9(1): 53-55, 2000 Jan.
Article in English | MEDLINE | ID: mdl-10629328

ABSTRACT

Microangiopathy is the most frequent complication of diabetes mellitus. It frequently precedes metabolic and biohumoral pathology. The diabetic foot is a particular aspect of the disease. Capillary videomicroscopy has proven to be a valuable technique for detecting early morpho-functional changes in the microcirculation in vivo. It is performed at the fingers' nailfold, at conjunctiva, and on the skin. This study aims to propose a qualitative assessment of microvascular complications in elderly patients with diabetes mellitus by toe nailfold capillary microscopy.

2.
Arch Gerontol Geriatr ; 22 Suppl 1: 523-6, 1996.
Article in English | MEDLINE | ID: mdl-18653088

ABSTRACT

UNLABELLED: A longitudinal study on the over 65-year-old population (656 subjects) of a little town in the district of Turin (Italy) has started. A random sample of 200 people, stratified for sex and age, has been extracted and subdivided into age groups of 5 years. The first multidimensional geriatric assessment has already been carried out. We intend to reevaluate the sample every 2.5 years. PRELIMINARY RESULTS: general conditions are good in 72% of cases, fairly good in 23%, mediocre in 4%, and poor in 1%. There is no significant correlation between the number of diseases for single subjects and advancing age, while there is a progressive increase of drug uses with aging. By using activities of daily living (ADL) scale, 73% of people are completely self-sufficient; as the number of diseases for single subjects increases, the level of self sufficiency decreases. Cognitive impairment, tested by mini mental state examination (MMSE), is present to various extents in 28.3% of the population. It increases with advancing age and is not influenced by the number of pathologies.

3.
Angiology ; 45(2): 137-41, 1994 Feb.
Article in English | MEDLINE | ID: mdl-8129189

ABSTRACT

Effects of picotamide on platelet activity and on some hemorheologic, coagulative, and hemodynamic parameters were investigated in a randomized, double-blind, placebo-controlled study for eighteen months. Twenty patients, average age 61.5 +/- 9.6 (SD) years, with peripheral arterial disease (PAD) at functional stage 2 of the Fontaine classification and with intermittent claudication for at least six months were studied. Ten patients received tablets of picotamide, 300 mg three times a day, and 10 subjects received three identical placebo tablets each day. Similar atherosclerotic disease risk factors were present in both groups. Picotamide induced a significant decrease of plasma viscosity, fibrinogen, and beta-thromboglobulin and an increase of amplitude of the photoplethysmographic wave.


Subject(s)
Arterial Occlusive Diseases/drug therapy , Intermittent Claudication/complications , Peripheral Vascular Diseases/drug therapy , Phthalic Acids/therapeutic use , Platelet Aggregation Inhibitors/therapeutic use , Arterial Occlusive Diseases/blood , Arterial Occlusive Diseases/complications , Arterial Occlusive Diseases/physiopathology , Blood Coagulation/drug effects , Blood Viscosity/drug effects , Double-Blind Method , Erythrocyte Deformability/drug effects , Fibrinogen/metabolism , Hemorheology , Humans , Male , Middle Aged , Peripheral Vascular Diseases/blood , Peripheral Vascular Diseases/complications , Peripheral Vascular Diseases/physiopathology , Photoplethysmography , Phthalic Acids/pharmacology , Platelet Aggregation Inhibitors/pharmacology , beta-Thromboglobulin/analysis
4.
Arch Ital Urol Androl ; 65(5): 533-8, 1993 Oct.
Article in Italian | MEDLINE | ID: mdl-8252083

ABSTRACT

With the improvement of quality life in the elderly of technologically developed countries, sexuality has become an important aspect of aging. In the elderly there is a progressive decline of organic functions; the decrease of sexual and procreating activity is linked with the impaired male hormonal production. The four stages of sexual function are modified: 1. delayed erection; 2. plateau prolongation; 3. orgasm modifications; 4. fast penis detumescence. In addition to organic impairment, aesthetic, social, environmental and psychological factors can restrict sexual activity, as well as past sexual experiences and co-morbidity. There are specific aspects concerning sexuality in the elderly, such as the increased chances of public relations and emotional involvement, the more intense psychic activity and the stronger process of removal and sublimation of impulses. In conclusion the best way to deal with sexuality in the elderly is the multidimensional assessment.


Subject(s)
Aged/psychology , Aging/physiology , Aging/psychology , Sexual Behavior , Erectile Dysfunction/etiology , Erectile Dysfunction/psychology , Humans , Male , Sexual Behavior/physiology
6.
Angiology ; 38(8): 575-80, 1987 Aug.
Article in English | MEDLINE | ID: mdl-3631642

ABSTRACT

A group of 11 female patients (mean age 33.7 +/- 8 years) with a clearly proven primary Raynaud's syndrome of up to five years' duration were subjected to a two-month oral treatment with 3 X 400 mg pentoxifylline per day. The following parameters were studied without and with exposure to cold conditions: hemodynamics (finger photoplethysmography), red cell deformability (filtration test), various clotting variables (prothrombin activity, antithrombin III, plasma fibrinogen, partial thromboplastin time, thrombin time, thrombelastogram), and clinical symptomatology. After treatment 7 of the 11 patients showed a distinct improvement of peripheral blood flow and of symptoms (decrease or removal of asphyxia attacks, pain, color change) under basal conditions, as well as after exposure to cold. Red cell filtration was significantly (p less than 0.05) improved, increasing by 35% under normal conditions and by 30% after exposure to cold. Positive changes were also found in respect to antithrombin III (increase) and plasma fibrinogen (decrease). The thrombelastogram was unchanged. Clinical and instrumental improvements were probably ascribable to better microcirculatory flow due to increased red cell deformability, reduced viscosity, and decreased fibrinogen, all capable of influencing in various degrees the blood flow at the microcirculatory level.


Subject(s)
Pentoxifylline/therapeutic use , Raynaud Disease/drug therapy , Theobromine/analogs & derivatives , Adult , Blood Coagulation Tests , Blood Viscosity , Erythrocyte Deformability , Female , Humans , Microcirculation , Plethysmography , Raynaud Disease/blood , Raynaud Disease/physiopathology
7.
Minerva Med ; 76(40): 1839-50, 1985 Oct 20.
Article in Italian | MEDLINE | ID: mdl-3903550

ABSTRACT

Certain non-invasive techniques like Doppler CW and strain gauge plethysmography are highly effective ways of evaluating the natural history of postphlebitic syndrome. 40 patients of both sexes, average age 51.5 +/- 6.9 with a history of deep venous thrombosis (28 documented phlebographically) were subjected to Doppler tests with assessment of venous blood pressure and bilateral strain gauge plethysmography. 34 of the 40 suspected PPS cases were confirmed, though not all cases were at the same stage. Persistent deep venous thrombosis was found in five of the extremities and the last one examined revealed a primary varicose syndrome. A comparison of the Doppler and phlebography results showed both to be highly sensitive techniques (100% accuracy). When the contralateral limbs were examined, the Doppler technique revealed 7 cases of PPS and 21 primary varices. In contrast strain gauge plethysmography identified all 28 cases of increased venous capacitance as primary varices, thus confirming the inability of this technique to distinguish between the various varicose conditions. Assuming the presence of a vascular diagnosis laboratory where both techniques are available, strain gauge plethysmography is recommended as the examination of choice. This technique is simple and fast to perform and can provide extensive information whether at rest (filling and emptying volumes and times; venous tone and distensibility, venous blood pressure at rest) or in movement (venous pressure when standing, muscular pumping index). Hence plethysmography can reveal any canalisation present even in the earliest stages though it cannot pinpoint the precise site of the deep obstruction. The longer, more complex Doppler CW procedure should be reserved for secondary investigations. This technique is preferable to plethysmography when a more accurate assessment of the degree, site and extension of the venous recanalisation is needed. Doppler CW also provides information on any valvar sequelae since it records the direction of the blood flow in the presence of a substitution syndrome (increased venous flow in the surface vessels). Finally if used in a rational manner the two techniques can be combined to eliminate contrast medium techniques, which would only be adopted as a preoperative measure.


Subject(s)
Thrombophlebitis/complications , Varicose Veins/diagnosis , Adult , Female , Humans , Male , Middle Aged , Phlebography , Plethysmography , Ultrasonography , Varicose Veins/etiology , Venous Insufficiency/diagnosis
8.
Minerva Med ; 76(30-31): 1401-5, 1985 Jul 31.
Article in Italian | MEDLINE | ID: mdl-4022431

ABSTRACT

1200 mg/day per os of Pentoxyphyllin administered for 60 day brought about an improvement in symptomatology and photoplethysmographic readouts under base conditions and following the cooling test in 7 out of 11 females suffering from Raynaud's disease. These results may be explained by an improved microcirculation flow resulting from increased erythrocyte filterability and a decrease in fibrinogenemia .


Subject(s)
Blood Coagulation/drug effects , Microcirculation/drug effects , Pentoxifylline/therapeutic use , Raynaud Disease/drug therapy , Theobromine/analogs & derivatives , Adult , Blood Coagulation Tests , Female , Humans , Pentoxifylline/administration & dosage , Pentoxifylline/pharmacology , Plethysmography , Raynaud Disease/blood
9.
Minerva Med ; 76(26-27): 1265-9, 1985 Jun 30.
Article in Italian | MEDLINE | ID: mdl-4011019

ABSTRACT

Deep-seated venous thrombosis (DVT) is more common in subjects over 40 and is most frequently found in subjects between 60 and 70 years of age. It is thought that the complaint is brought about by paraphysiological factors connected with aging or conditions frequently encountered in the elderly which are interconnected to varying extents. The flow parameters of 30 female subjects with diagnosed DVT, of which 18 were over 60, and 24 female subjects with a phlebographic diagnosis of Post-phlebocytic syndrome (PPS), of which 14 were over 60, were evaluated using the plethysmographic strain gauge technique. Women over 60 with DVT have longer maximum emptying times and higher venous pressures. For this group, maximum emptying time is slightly lower (although not by a statistically significant amount) than for the younger group. Subjects of advanced age with DVT display significantly higher levels of venous obstruction and patients with PPS display higher levels of venous ectasia. These effects are probably caused by venous circulation miopragia due to aging.


Subject(s)
Plethysmography/methods , Thrombophlebitis/physiopathology , Aged , Aging , Blood Circulation , Female , Humans , Male , Middle Aged , Syndrome , Thrombophlebitis/complications , Veins/physiopathology
12.
Minerva Med ; 72(39): 2617-20, 1981 Oct 13.
Article in Italian | MEDLINE | ID: mdl-7290465

ABSTRACT

A study of 60 over-65's, of whom 30 were suffering from coronary disease 15 had previous but now stable cerebrovascular insufficiency and 15 were suffering from circulation insufficiency in the lower extremities, showed that ADP-induced platelet aggregability was significantly increased by comparison with a group of 15 subjects of similar age rigidly selected as "normal". The aggregation rate was more enhanced than other parameters. In patients with coronary insufficiency and in those with cerebral vasculopathy, other aggregability parameters were significantly changed (minimum aggregating concentration). It is concluded that platelet aggregation, which is often increased in physiological ageing, is altered to an even greater extent in the vasculopathic elderly.


Subject(s)
Adenosine Diphosphate/pharmacology , Aging , Platelet Aggregation/drug effects , Vascular Diseases/blood , Aged , Arteriosclerosis/blood , Cerebrovascular Disorders/blood , Coronary Disease/blood , Humans , Reaction Time
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