ABSTRACT
We used state of the art CMR to define ranges for normal left ventricular volumes and systolic/diastolic function normalized to the influence of gender, body surface area and age. New CMR normalized ranges were modeled and displayed in graphical form for clinical use, with normalization for body surface area, gender, and age. The determination of normality, or the severity of abnormality, depends on the use of the appropriate reference ranges normalized to all 3 variables. These novel data have particular importance for clinical practice and clinical trials using CMR.
Subject(s)
Diastole/physiology , Magnetic Resonance Imaging/methods , Systole/physiology , Ventricular Function, Left/physiology , Adult , Age Factors , Aged , Aged, 80 and over , Analysis of Variance , Female , Humans , Image Processing, Computer-Assisted , Linear Models , Male , Middle Aged , Reference Values , Sex Factors , Statistics, NonparametricSubject(s)
Cardiomegaly/diagnosis , Electrocardiography , Heart Transplantation/physiology , Postoperative Complications/diagnosis , Ventricular Function, Left/physiology , Cardiomegaly/physiopathology , Drug Therapy, Combination , Female , Humans , Immunosuppressive Agents/therapeutic use , Male , Middle Aged , Postoperative Complications/physiopathology , Reference ValuesABSTRACT
The study aimed to assess ventricular function in response to increasing doses of dobutamine in healthy young volunteers. Isotopic ventriculography was performed at baseline, low dose (10 microg/Kg/min) and high dose (40 microg/Kg/min) of dobutamine. Global and segmentary ejection fraction, ejection fraction in the first third of systole, peak filling rate and peak filling rate time were analysed. A progressive increase in the global ejection fraction in relation to the increasing doses was observed. The segmentary ejection fraction and ejection fraction in the first third of systole also increased with the low dose, but no significant differences were found between both doses. Concerning the diastolic function, the peak filling rate increased significantly with both doses, with no differences between them. We conclude that dobutamine at these doses leads to an increase in all systolic parameters and in the peak filling rate without changing the peak filling rate time in healthy subjects.
Subject(s)
Cardiotonic Agents , Dobutamine , Ventricular Function, Left/physiology , Adolescent , Adult , Analysis of Variance , Cardiotonic Agents/administration & dosage , Diastole/physiology , Dobutamine/administration & dosage , Hemodynamics , Humans , Male , Radionuclide Ventriculography , Sensitivity and Specificity , Systole/physiologyABSTRACT
Forty healthy male volunteers, aged 1,7 +/- 0.9 years, were studied to verify any possible differences in lung and heart Thallium-201 uptake with different types of stress. All of them were studied with myocardial perfusion SPECT after the injection of 201Thallium. The 40 individuals were randomized into four groups of 10 subjects and each group was subjected to a different type of stress: physical exercise, dobutamine, dipyridamole and adenosine triphosphate (ATP). Significant differences were observed with regard to lung and heart 201Thallium uptake, both of them being lower with physical exercise than with any of the drugs. However, the lung/heart ratio was equivalent for all the groups. We conclude that, even though physical exercise induces a lower lung and heart 201Thallium uptake than does pharmacological stress, the lung/heart ratio is comparable in the four types of stress and has a value of 0.28 +/- 0.03 in healthy young subjects.
