[The role of sympathetic reactivity in the development of Raynaud's syndrome]. / Rol' simpaticheskoi reaktivnosti v razvitii sindroma Reino.

Finger skin blood flow was studied in 131 patients with Raynaud's syndrome using laser Doppler flowmetry. Scleroderma systematica, systemic lupus erythematosus, rheumatoid arthritis, Sjogren's disease, mixed connective tissue lesions, Raynaud's disease were diagnosed in 61, 17, 10, 10, 10 and 13 examinees, respectively. Control consisted of 20 healthy subjects. The response of the blood flow was registered in response to functional tests activating sympathetic nervous system: indirect cooling, emotional stress, deep inhalation, Valsalva's test. Hyper-response to the above sympathetic stimulation was noted in none of the groups studied. In scleroderma systematica the reactivity significantly decreased with longer disease duration. It is clear that the study did not confirm the leading role of sympathetic hyperactivity in Raynaud's syndrome pathogenesis.

The chronic toxicity of the preparation M-71 (Craviten).

The studies of chronic toxicity of the preparation M-71 (Craviten) were carried out on rats and mice. The body weight, absolute and relative weight or organs, haematocrit, the number of erythrocytes and leukocytes, the proportional content of leukocytes, OB value, activity of aminotransferases (AspAT and AlAT), the level of glucose in the blood serum and the histopathology of some organs were investigated. Moreover, in rats receiving M-71 intraperitoneally, the amount of electrolytes and the daily excretion of urine was studied. The results suggest that M-71 did not change the investigated parameters.