ABSTRACT
Abdominal adiposity is associated with tumor development and poor clinical outcomes in breast cancer (BC) and can be identified by the measurement of waist circumference (WC) and visceral adipose tissue (VAT). This study aimed to evaluate the association between waist circumference (WC) and imaging measurement of central adiposity according to age group in women with BC. Abdominal adiposity was assessed by WC and VAT, obtained by dual-energy X-ray absorptiometry (DXA). Body mass index (BMI) was assessed. The presence of inflammation was investigated by measuring C-Reactive Protein (CRP) levels. Multivariate linear regression models were applied to verify the association between WC and VAT. The significance level adopted for all tests was 5%. This study included 112 women with a mean age of 55.5 ± 11.4 years. After adjusted models, WC remained associated with VAT and for every centimeter increase in WC, there was an increase of 3.12 cm2 (CI: 2.40 - 3.85; p < 0.001) in VAT. WC was associated with VAT in women with breast cancer, proving to be a simple, fast, and noninvasive approach that can be used as a proxy to identify visceral fat.
Subject(s)
Breast Neoplasms , Intra-Abdominal Fat , Humans , Female , Adult , Middle Aged , Aged , Waist Circumference , Intra-Abdominal Fat/diagnostic imaging , Intra-Abdominal Fat/metabolism , Intra-Abdominal Fat/pathology , Breast Neoplasms/pathology , Obesity/metabolism , Body Mass Index , Obesity, AbdominalABSTRACT
Lactating adenoma is a rare benign breast lesion that most often presents as a small (up to 3 cm), solid, well-circumscribed, solitary, painless, mobile, lobulated mass. The highest incidence occurs in primiparous women (20 to 40 years old) during the third trimester of pregnancy. However, in the rare case presented herein, in addition to its giant size (more than 10 centimeters on palpation), this lactating adenoma is distinctive due to the presence of multiple nodules, poorly defined ultrasonographic margins, worrisome radiologic features, growth since early pregnancy, presence of infarction and association with chronic mastitis. From the clinical-radiologic perspective, the differential diagnoses included abscess associated with puerperal mastitis, phyllodes tumor, and galactocele. Biopsy was performed, and pathologic examination revealed the classic characteristics of lactating adenoma with multiple infarcted areas, leading to an unexpected confirmed case of giant lactating adenoma.
ABSTRACT
Fendas orais são malformações prevalentes, requerem cuidado multiprofissional do nascimento até a vida adulta, envolvendo promoção da saúde, prevenção de comorbidades e reabilitação clínico-cirúrgica. Em Alagoas, a atenção nesta área não está estruturada resultando em iniquidades e fragmentação do cuidado. Neste estudo foi concebido e testado um sistema de referência e contrarreferência em genética usando as fendas orais como modelo. MÉTODOS: (a) articulação com a Secretaria de Estado da Saúde para conceber o fluxo do sistema; (b) pactuação com gestores em maternidades dos municípios-alvo; (c) capacitação dos profissionais;(d) desenvolvimento de materiais informativos (formulários, manuais,cartazes etc.); (e) os dados dos pacientes foram coletados através da Cran Flow® durante as consultas médicas e analisados usando Microsof tExcel e Epi-Info . RESULTADOS: A partir da articulação entre os municípios-alvo e o Serviço de Genética Clínica, 50 pacientes foram referidos e contrarreferidosentre outubro/2014 e fevereiro/2016. Este número foi igual à soma de atendimentos oriundos da demanda espontânea à Genética no período 2010-2016. Em linhas gerais, as características genético-clínicas corroboraram a literatura. Chamou a atenção a baixa frequência dediagnóstico pré-natal inclusive em casos sindrômicos. Baixa escolaridade materna, recorrência familial e ingestão de álcool na gravidez foram os fatores de risco mais prevalentes. CONCLUSÕES: o sistema de referência e contrarreferência mostrou-se válido e passível de extensão a outros defeitos congênitos e estados brasileiros.Os resultados também forneceram subsídios para a construção de uma política de saúde voltada para as necessidades específicas de pessoas com fendas orais em Alagoas.
Oral clefts are prevalent malformations that demand multiprofessional carefrom birth up to adulthood. It involves health promotion, prevention ofcomorbidities and clinical and surgical rehabilitation. In Alagoas, there isno structured care in this setting resulting in iniquities and fragmentation of assistance. In this study, a reference and counter-reference system ingenetics was created and tested using oral clefts as a model. Methods: (a)articulation with State Health Secretary to conceive the systems flow; (b)agreement between stakeholders and maternity hospitals in the targetcounties;(c) training of professionals; (d) development of informativematerials (forms, handbooks, posters etc.); (e) patients data were collectedthrough CranFlow® during medical appointments and analysed usingMicrosoft Excel e Epi-Info. Results: From the articulation betweentarget-counties and the Service of Clinical Genetics, 50 patients werereferred and counter-referred between October/2014 and February/2016.That figure was equivalent to the sum of consultations from spontaneousdemand to the Genetics in the period 2010-2016. In general, clinicalgeneticcharacteristics corroborate the literature. Drew attention the lowfrequency of prenatal diagnosis including syndromic cases. Little maternaleducation, familial recurrence and alcohol consumption during pregnancywere the most prevalent risk factors. Conclusions: the reference andcounter-reference system showed up valid and capable of extension toother congenital defects and Brazilian states. The results also providedsubsidies for the construction of a health policy target to specific needs ofpeople with orofacial clefts in Alagoas.
Subject(s)
Humans , Cleft Lip , Cleft Palate , Unified Health System , GeneticsABSTRACT
The aim of the study has been to evaluate the morphology, proliferation, and pluripotency maintenance of mouse embryonic stem cells (mESCs) cultivated on poly(lactic-co-glycolic acid) scaffolds. The scaffolds were hydrolyzed with NaOH (treated) and nonhydrolyzed (untreated). Morphological and mechanical characterization of the scaffolds was performed. mESC were evaluated for cell viability, cytotoxicity, expression of pluripotency markers, colony morphology, and overall distribution. The treatment generated a reduction in the hydrophobic characteristics of the scaffolds, leading to a higher wettability compared to the untreated group. The viability, cytotoxicity, number of colonies, and the thickness of the cell layer presented similar results between the scaffold groups. The viability test showed that it was possible to cultivate the mESCs on the scaffolds. The cytotoxicity analysis showed that the PLGA scaffolds were not harmful for the cells. The cells maintained the expression of the pluripotency markers Oct4 and Sox2. The number of colonies and the thickness of the cell layer on the scaffold showed that they were not able to colonize the entire volume of the scaffolds. The area occupied by the mESCs was the same between the treated and untreated groups after 14 days in culture. It is possible to conclude that both conditions are equally suitable for maintaining mESC culture. © 2016 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 105A: 424-432, 2017.
Subject(s)
Cell Proliferation , Materials Testing , Mouse Embryonic Stem Cells/metabolism , Polyglactin 910/chemistry , Tissue Scaffolds/chemistry , Animals , Female , Mice , Mouse Embryonic Stem Cells/cytologyABSTRACT
Os conselhos de saúde são instituições de democracia participativa. As resoluções dos conselhos devem ser homologadas pelos gestores. Este estudo analisa as resoluções não homologadas dos conselhos municipais de saúde de Belo Horizonte e São Paulo no período de 2004 a 2013 com o objetivo de observar se existe algum padrão incidindo na homologação ou não das resoluções dos Conselhos Municipais de Saúde de Belo Horizonte e São Paulo, conforme o partido político que estava na gestão dos municípios no período. A metodologia utilizada foi a análise descritiva das resoluções aprovadas pelos Conselhos de Saúde das duas capitais que não apresentavam registro de homologação pelo Executivo. Os dados foram coletados nos arquivos de resoluções e sites dos Conselhos, e os resultados relacionados ao mandato dos prefeitos e respectivos partidos. Ao final pôde-se constatar um maior reconhecimento das decisões destas arenas institucionais de democracia participativa por parte do Partido dos Trabalhadores, seguido pelo Partido da Social Democracia Brasileira e Partido Socialista Brasileiro, e uma menor homologação das decisões dos conselhos pelo Partido da Frente Liberal, Democratas e Partido Social Democrático, demostrando que os partidos de ideologia socialista respeitam mais os espaços de democracia participativa estudados que os de ideologia liberal
Health councils are institutions of participatory democracy. The councils' resolutions must be approved by the managers. This study analyses the resolutions that were not approved in the municipal health councils of Belo Horizonte and São Paulo from 2004 until 2013. The main goal is to assess whether there is pattern influencing the approval or not of resolutions in the aforementioned municipal health councils givem the party in power in the city...
Subject(s)
Health Councils/organization & administration , Resolutions/policies , Democracy , RatificationABSTRACT
OBJECTIVES: To isolate cells from pulp of intact cryopreserved deciduous teeth. The null hypothesis raised here is to find no difference in the establishment of cell culture after cryopreservation (1) using culture medium supplemented with different concentrations of fetal bovine serum (FBS); and (2) between teeth with different stages of physiological root resorption. STUDY DESIGN: Intact deciduous teeth with different root resorption stages were cryopreserved using FBS and Dimethyl Sulfoxide (DMSO) medium (9:1) in a progressive freezing process, by placing the samples in the refrigerator (4 degrees C/60 min) and subsequently transferring them to a -80 degrees C freezer (controlled device -1 degrees C/min/24 hours), and finally into liquid nitrogen (-196 degrees C/30 days). After the thawing process, the cell isolation was performed by enzymatic digestion (type I collagenase). The cells were re-suspended into the culture medium with 10% (G1) or 20% (G2) of FBS. Microscopic analysis was performed after 30 days to visualize the cell attachment. RESULTS: The culture establishment rate was higher in G2 (75%) than G1 (12.5%) (p = 0.041). There was no difference between the different stages of root resorption. CONCLUSIONS: It was possible to establish cell cultures from the pulp of intact cryopreserved deciduous teeth. The use of 20% FBS after thawing improved the culture rate.
Subject(s)
Blood , Culture Media , Dental Pulp/cytology , Tooth, Deciduous/cytology , Adolescent , Animals , Cattle , Cell Adhesion/physiology , Cell Culture Techniques , Cell Separation/methods , Child , Cold Temperature , Cryopreservation/methods , Cryoprotective Agents/administration & dosage , Dimethyl Sulfoxide/administration & dosage , Freezing , Humans , Root Resorption/pathology , Root Resorption/physiopathologyABSTRACT
O objetivo deste estudo é observar como vem se dando a relação entre a democracia participativa e representativa no Conselho Municipal de Saúde de Belo Horizonte (CMS/BH) desde a sua fundação em 1991 até 2010. A metodologia utilizada foi a análise das homologações e vetos do Executivo sobre as resoluções do conselho, com um aprofundamento no período entre 1997 e 2008. Os dados foram coletados no Arquivo de Resoluções e no site do CMS/BH. Os resultados foram relacionados ao mandato dos prefeitos e ao segmento dos presidentes do conselho. Os resultados demonstram que apenas uma resolução foi vetada pelo Executivo, mas 26% não apresentam registro de homologação, sendo que 41% destas apresentaram oposição dos gestores na votação. Espera-se que a realidade apresentada possa nos levar a reflexões quanto às práticas de poder, encorajando os conselheiros para a construção efetiva da democracia participativa neste espaço.
The scope of this study is to observe how the relationship between participative and representative democracy in Belo Horizonte's Municipal Health Council (Conselho Municipal de Saúde de Belo Horizonte - CMS/BH) has been developing since its foundation in 1991 through to 2010. The methodology applied involved the analysis of approvals and vetoes from the Executive power regarding the council's resolutions, with special emphasis on the period between 1997 and 2008. The data were collected from the Resolutions Archive and from the CMS/BH webpage. The results were related to each mayor's term and to the segment of the council's presidents. The results show that only one resolution was vetoed by the Executive power, however 26% of the resolutions do not show any record of ratification, whereby 41% of these faced opposition from the authorities in the voting process. It is hoped that the reality presented may lead to reflections regarding the exercise of power, encouraging the council members to effectively build participative democracy in this space.
Subject(s)
Democracy , Government , Public Health , Public Policy , Brazil , Time FactorsABSTRACT
The scope of this study is to observe how the relationship between participative and representative democracy in Belo Horizonte's Municipal Health Council (Conselho Municipal de Saúde de Belo Horizonte - CMS/BH) has been developing since its foundation in 1991 through to 2010. The methodology applied involved the analysis of approvals and vetoes from the Executive power regarding the council's resolutions, with special emphasis on the period between 1997 and 2008. The data were collected from the Resolutions Archive and from the CMS/BH webpage. The results were related to each mayor's term and to the segment of the council's presidents. The results show that only one resolution was vetoed by the Executive power, however 26% of the resolutions do not show any record of ratification, whereby 41% of these faced opposition from the authorities in the voting process. It is hoped that the reality presented may lead to reflections regarding the exercise of power, encouraging the council members to effectively build participative democracy in this space.
Subject(s)
Democracy , Government , Public Health , Public Policy , Brazil , Time FactorsABSTRACT
O fibroadenoma é a neoplasia benigna mais freqüente da mama feminina e é considerado tumor misto, constituído por quantidades variáveis de tecido conjuntivo e epitelial. A ciclosporina parece ter implicações no desenvolvimento de fibroadenomas mamários em pacientes transplantadas renais em idade reprodutiva. Descrevemos o caso no qual a paciente, em uso terapêutico de ciclosporina A, após transplante renal, apresentou vários nódulos mamários bilaterais na evolução. O exame físico e os achados de imagem sugeriram fibroadenoma, diagnóstico que foi confirmado após biópsias.
Fibroadenoma is the most frequent benign neoplasia in the female breast and it is considered a mixed tumor, constituted by variable amounts of connective and epithelial tissue. Cyclosporine A seems to be related with the development of mamary fibroadenomas in patients who underwent kidney transplantation in reproductive age. We reported the case in which the patient, in therapeutic use of cyclosporine A, after kidney transplantation, presented several bilateral lumps. The imaging and palpable findings suggested fibroadenoma, confirmed after biopsy.
