ABSTRACT
BACKGROUND: Atrial fibrillation (AF) is the most commonly sustained cardiac rhythm disturbance. Surgical ablation techniques were developed involving the left atrium only and modifications of the maze procedure in ablating both atria. OBJECTIVE: The aim of this study was to compare, in patients with permanent AF, the efficacy of uniatrial versus biatrial radiofrequency ablation procedure in the treatment of chronic atrial fibrillation in patients with associated cardiac disease. METHOD: Between September 2003 and May 2009, 30 patients were submitted to the radiofrequency ablation procedure for AF associated with concomitant cardiac surgery; 15 patients underwent a uniatrial procedure, and 15 patients underwent biatrial ablation. The mean age was 47.73 ± 9.85 years, and 53.4% were men. The average followup time was 12.16 ± 10.89 months for the uniatrial group and 7.0 ± 4.0 months for the biatrial group. RESULTS: Neither hospital mortality nor complications related to radiofrequency ablation were was registered. At the time of hospital discharge, 9 patients (60%) were in a state of sinus rhythm in both groups. However, patients undergoing biatrial ablation (range 73.3% versus 46.7%) demonstrated complete freedom from atrial fibrillation at all times. CONCLUSION: Biatrial ablation surgical procedures were more effective in controlling atrial fibrillation than procedures limited to the left atrium.
Subject(s)
Atrial Fibrillation/surgery , Catheter Ablation/instrumentation , Pulmonary Veins/surgery , Adult , Anti-Arrhythmia Agents/therapeutic use , Anti-Bacterial Agents/therapeutic use , Atrial Fibrillation/drug therapy , Female , Health Status Indicators , Heart Atria/pathology , Humans , Male , Middle Aged , Prospective Studies , Statistics, Nonparametric , Time FactorsABSTRACT
OBJECTIVE: To evaluate the results of intraoperative radiofrequency ablation with biatrial procedure in the treatment of chronic atrial fibrillation in patients with associated cardiac disease. METHODS: Between February 2008 and May 2009, 15 consecutive patients were underwent mitral valve procedure plus modified radiofrequency biatrial ablation of chronic atrial fibrillation. The mean age was 47.73 +/- 9.85 years and 60% were male. The mean left atrial diameter was 55.06 +/- 7.56 mm. RESULTS: There were no hospital mortality or complications related to radiofrequency ablation. The mean follow-up period was 7 +/- 4 months. At the time of hospital discharge nine (60%) patients were in sinus rhythm. After a mean follow-up period 11 (73.3%) were in sinus rhythm. CONCLUSION: Intraoperative biatrial radiofrequency ablation is a safe and effective technique for the treatment of chronic atrial fibrillation, with satisfactory midterms outcomes in terms of conversion to sinus rhythm.
Subject(s)
Atrial Fibrillation/surgery , Catheter Ablation/adverse effects , Mitral Valve/surgery , Adult , Atrial Fibrillation/physiopathology , Catheter Ablation/methods , Chronic Disease , Female , Hospital Mortality , Humans , Male , Middle Aged , Treatment OutcomeABSTRACT
OBJETIVO: Apresentar o resultado inicial da ablação operatória de fibrilação atrial (FA) por radiofrequência irrigada, aplicada em ambos os átrios, para reversão e manutenção do ritmo sinusal, a curto e médio prazo, nos pacientes submetidos à operação cardíaca concomitante da valva mitral. MÉTODOS: Entre fevereiro de 2008 e maio de 2009, 15 pacientes consecutivos portadores de FA permanente foram submetidos à ablação intraoperatória da taquiarritmia por radiofrequência irrigada, aplicada de forma biatrial, com operação cardíaca concomitante (plastia ou troca valvar mitral). O grupo era constituído de nove (60 por cento) pacientes do sexo masculino, com idades variando de 25 a 59 anos (média de 47,73 ± 9,85 anos). O diâmetro do átrio esquerdo variou de 44 a 70 mm (média de 55,06 ± 7,56 mm). RESULTADOS: Não houve mortalidade hospitalar ou complicações relacionadas à radiofrequência. Na alta hospitalar, 9 (60 por cento) pacientes estavam em ritmo sinusal. No tempo médio de seguimento de 7 ± 4 meses, 11 (73,3 por cento) pacientes estavam em ritmo sinusal. CONCLUSÕES: A ablação operatória por radiofrequência irrigada da fibrilação atrial crônica, aplicada em ambos os átrios, é efetiva na reversão e manutenção do ritmo sinusal, no seguimento a curto e médio prazo. A inclusão de maior número de pacientes e a continuidade do seguimento pós-operatório são necessárias para confirmar a efetividade da técnica empregada.
OBJECTIVE: To evaluate the results of intraoperative radiofrequency ablation with biatrial procedure in the treatment of chronic atrial fibrillation in patients with associated cardiac disease. METHODS: Between February 2008 and May 2009, 15 consecutive patients were underwent mitral valve procedure plus modified radiofrequency biatrial ablation of chronic atrial fibrillation. The mean age was 47.73 ± 9.85 years and 60 percent were male. The mean left atrial diameter was 55.06 ± 7.56 mm. RESULTS: There were no hospital mortality or complications related to radiofrequency ablation. The mean follow-up period was 7 ± 4 months. At the time of hospital discharge nine (60 percent) patients were in sinus rhythm. After a mean follow-up period 11 (73.3 percent) were in sinus rhythm. CONCLUSION: Intraoperative biatrial radiofrequency ablation is a safe and effective technique for the treatment of chronic atrial fibrillation, with satisfactory midterms outcomes in terms of conversion to sinus rhythm.
Subject(s)
Adult , Female , Humans , Male , Middle Aged , Atrial Fibrillation/surgery , Catheter Ablation/adverse effects , Mitral Valve/surgery , Atrial Fibrillation/physiopathology , Chronic Disease , Catheter Ablation/methods , Hospital Mortality , Treatment OutcomeABSTRACT
OBJECTIVE: The following report describes the experience of the Cardiovascular Surgery Team of the ABC Medical School with coronary-coronary bypass grafting. METHODS: Four patients undergone off-pump coronary artery bypass grafting, with coronary-coronary bypass of the right coronary artery, by using great saphenous vein graft. RESULTS: The follow-up period was 3 to 5 years without any intra- or postoperative recurrence. One patient presented anginal symptoms four years after the surgery and underwent cinecoronariography that revealed patent anastomosis. CONCLUSION: The coronary-coronary bypass is a good option for patients undergone coronary artery bypass grafting.
Subject(s)
Coronary Artery Bypass/methods , Coronary Vessels/surgery , Aged , Coronary Artery Bypass/adverse effects , Follow-Up Studies , Humans , Male , Middle Aged , Saphenous Vein/transplantationABSTRACT
OBJETIVO: Descrever a experiência do Serviço de Cirurgia Cardiovascular da Faculdade de Medicina da Fundação do ABC com a revascularização do miocárdio com ponte coronária-coronária. MÉTODOS: Foram analisados quatro pacientes submetidos a operação com ponte coronária-coronária, todos sem circulação extracorpórea. Em todos os casos, foi realizada ponte coronária-coronária na artéria coronária direita exclusivamente, utilizando segmento da veia safena magna. RESULTADOS: Não houve nenhuma intercorrência intra ou pós-operatória. O tempo de seguimento variou de 3 a 5 anos. Apenas um dos pacientes apresentou angina após quatro anos da operação, sendo submetido a cinecoronariografia, que demonstrou ponte coronária-coronária livre de lesões. CONCLUSÃO: A ponte coronária-coronária constitui opção viável e satisfatória para pacientes submetidos à revascularização do miocárdio
OBJECTIVE: The following report describes the experience of the Cardiovascular Surgery Team of the ABC Medical School with coronary-coronary bypass grafting. METHODS: Four patients undergone off-pump coronary artery bypass grafting, with coronary-coronary bypass of the right coronary artery, by using great saphenous vein graft. RESULTS: The follow-up period was 3 to 5 years without any intra- or postoperative recurrence. One patient presented anginal symptoms four years after the surgery and underwent cinecoronariography that revealed patent anastomosis. CONCLUSION: The coronary-coronary bypass is a good option for patients undergone coronary artery bypass grafting
Subject(s)
Aged , Humans , Male , Middle Aged , Coronary Artery Bypass/methods , Coronary Vessels/surgery , Coronary Artery Bypass/adverse effects , Follow-Up Studies , Saphenous Vein/transplantationABSTRACT
A detecção de marcadores tumorais é de fundamental importância para o diagnóstico do estágio das neoplasias, assim como a presença de metástases e na decisão do tratamento a ser utilizado bem como terapias adjuvantes. O objetivo deste trabalho é debater sobre alguns dos marcadores mais utilizados no diagnóstico do câncer além de discutir as técnicas utilizadas na sua detecção. Pode-se utilizar muito da tecnologia que a biologia molecular dispõe para a identificação e amplificação de determinado gene, pois muitos marcadores tumorais apresentam aumento da expressão por amplificação gênica, como é o caso do c-erb-B2. A identificação desses marcadores é realizada através de técnicas de RT-PCR, de imunohistoquímica, de hibridização e a de hibridização in situ. A hibridização para detecção de DNA, RNA ou proteínas é denominada respectivamente Southern Blot, Northern Blot e Western Blot. Dado o grande número de marcadores tumorais conhecidos e as diferentes formas de detecção de cada um, é essencial que protocolos sejam padronizados internacionalmente para que tais marcadores sejam avaliados de uma maneira única.
