Your browser doesn't support javascript.
loading
Show: 20 | 50 | 100
Results 1 - 20 de 66
Filter
1.
Empir Softw Eng ; 28(3): 80, 2023.
Article in English | MEDLINE | ID: mdl-37200579

ABSTRACT

Empirical research on software development practices in startups is growing. However, little has been investigated about how User eXperience (UX) work has been carried out in software startups. The primary objective of this paper is to investigate what software startups need from UX work. To achieve this goal, we conducted open-ended interviews and retrospective meetings with 16 software professionals from two software startups in Brazil. We analysed the data qualitatively using different coding approaches: initial coding, focused coding, and theoretical coding. We found 14 UX work-related needs which emerged from the daily practices used for software development in the two startups studied. Based on our findings, we propose an initial theoretical framework that highlights two theoretical themes and four groups underlying the needs identified. Our study reveals several relationships between UX work-related needs which are helpful to understand in order to identify what startups need from UX work in practice and to focus startup teams' efforts on the most urgent needs. As future work, we plan to explore ways in which these needs may be addressed so that UX work may be put into practice in software startups.

2.
REME rev. min. enferm ; 27: 1493, jan.-2023.
Article in English, Portuguese | BDENF - Nursing, LILACS | ID: biblio-1518175

ABSTRACT

Objetivo: avaliar o Desempenho da Gestão Organizacional dos Serviços Hospitalares no Brasil. Método: estudo transversal que utilizou dados do Programa Nacional de Avaliação dos Serviços de Saúde-PNASS 2015-2016 para avaliar o Desempenho da Gestão Organizacional de 1.665 hospitais do Brasil. Foram utilizados 30 itens de verificação distribuídos em 5 critérios (Gestão de Contratos; Gestão de Pessoas; Gestão da Informação; Planejamento e Organização; e Modelo Organizacional), que compuseram um escore de avaliação. O desempenho foi avaliado segundo os indicadores: porte hospitalar; nível de complexidade; esfera administrativa; tipo de gestão; e região do país. Verificou-se associação entre Desempenho da Gestão Organizacional dos hospitais com os indicadores Taxa de Ocupação, Média de Permanência e Valor Médio da AIH. Utilizou-se Análise de Componentes Principais para verificar a relação de dependência entre as variáveis e explicar a variabilidade dos dados. Foi utilizado o modelo de regressão logística ajustado para verificar variáveis que melhor explicam o Desempenho da Gestão Organizacional. Resultados: a média de Desempenho da Gestão Organizacional dos hospitais foi 63,83. Os melhores desempenhos estão nos hospitais da região Sul, de nível de Complexidade 8, acima de 150 leitos, de Esfera Administrativa Público Federal e de Gestão Estadual. Na análise de regressão logística, o desempenho se mostrou associado com: Taxa de Ocupação (p<9.87E-09), Porte hospitalar (p<4.49E-10), gestão municipal (p<0.004), Nível Hierárquico Nível 7 (p<0.042), Nível 8 (p<0.022) região Sul (p<0.004), Sudeste (p<0.002). Conclusão: o PNASS se mostrou adequado para avaliar o desempenho da gestão dos hospitais, sendo constatada relação entre melhor desempenho e maior porte e complexidade do hospital.(AU)


Objective: to assess the organizational management performance of hospital services in Brazil. Method: a cross-sectional study that resorted to data from the 2015-2016 National Program for the Evaluation of Health Services (Programa Nacional de Avaliação dos Serviços de Saúde, PNASS) to assess the Organizational Management Performance in 1,665 Brazilian hospitals. A total of 30 verification items distributed into 5 criteria (Contract Management; People Management; Information Management; Planning and Organization; and Organizational Model) were used, which comprised an evaluation score. Performance was assessed according to the following indicators: hospital size; complexity level; administrative sphere; type of management; and region of the country. An association was verified between the hospitals' Organizational Management Performance and the Occupancy Rate, Mean Hospitalization Time and Mean HA Value indicators. Principal Components Analysis was used to verify the dependence relationship between the variables and to explain data variability. An adjusted logistic regression model was used to verify variable that best explain Organizational Management Performance. Results: the hospitals' mean Organizational Management Performance was 63.83. The best performance levels correspond to the hospitals from the South region, Complexity level 8, more than 150 beds, belonging to the Federal Public Administrative Sphere and with State Management. In the logistic regression analysis, performance proved to be associated with: Occupancy Rate (p<9.87E-09), Hospital size (p<4.49E-10), Municipal Management (p<0.004), Hierarchical Level 7 (p<0.042), Level 8 (p<0.022), South region (p<0.004), and Southeast region (p<0.002). Conclusion: the PNASS proved to be adequate to assess the hospitals' management performance, verifying a relationship between better performance and larger hospital size and higher complexity.(AU)


Objetivo: evaluar el Desempeño de la Gestión Organizativa de los Servicios Hospitalarios en Brasil. Método: estudio transversal que utilizó datos del Programa Nacional de Evaluación de Servicios de Salud-PNASS 2015-2016 para evaluar el Desempeño de la Gestión Organizativa de 1665 hospitales en Brasil. Se utilizaron 30 elementos de verificación distribuidos en 5 criterios: Gestión de Contratos, Gestión de Personas, Gestión de la Información, Planificación y Organización, Modelo Organizativo, que compusieron una puntuación de evaluación...(AU)


Subject(s)
Humans , Health Services Administration , Health Management , Health Services Research , National Health Programs , Health Evaluation/statistics & numerical data , Brazil
3.
Comput Support Coop Work ; 32(2): 237-273, 2023.
Article in English | MEDLINE | ID: mdl-35496815

ABSTRACT

While CSCW researchers have studied collaboration across distance for more than two decades, the scale and context of geographically distributed work during the pandemic is unprecedented. Working from home as the default setting during the COVID-19 pandemic provides a unique opportunity for CSCW research to explore and develop new understandings of what it entails to engage in distributed collaborative work during a global crisis. In this paper, we revisit the distance framework, originally developed by Olson and Olson in 2000, through empirical data collected during the critical moments where COVID-19 was declared a pandemic and the world shut down: namely March 2020. We use the data to interrogate the distance framework and to extend it with a new dimension - Crisis Readiness. Crisis Readiness stipulates that for organizations to successfully respond to crises, four factors are required: 1) the ability to respond fast with dramatic measures; 2) the ability to supply adequate infrastructure to their employees; 3) the ability to adapt work practice responding to new work and life conditions; and 4) the ability to handle multiple and diverse interruptions both at the individual and organizational levels. Our contribution to CSCW research is a revised distance framework, which demonstrates that for geographically distributed work to be successful during a global crisis, cooperating actors need to achieve Common Ground, engage in different types of coupled work, be ready for collaboration and collaboration technology - and lastly, work in an organization which demonstrates Crisis Readiness.

4.
Braz. J. Pharm. Sci. (Online) ; 59: e21683, 2023. tab
Article in English | LILACS-Express | LILACS | ID: biblio-1520315

ABSTRACT

Abstract To control urban pests, especially cockroaches of the Periplaneta americana species, various pesticides have been developed that are increasingly potent and effective. However, the unrestrained application of pesticides has had negative consequences, such as the disappearance of some useful insect species and, consequently, the appearance of new pests, both in the countryside and cities. Due to the current scenario, it was necessary to search for new alternatives for the control of these insects. Among the species studied, Copaíba stood out. The oils were analyzed using GC-MS, b-caryophyllene and a-bergamotene being the predominant compounds. Repellency tests were performed with three different concentrations of C. officinalis and C. reticulata, 500 μg/mL, 250 μg/mL and 125 μg/mL, in triplicate. It can be observed that the oil of C. officinalis was more repellent to the nymphs at concentrations of 500 μg/mL and 250 μg/mL, however, when the behavior in nymphs exposed to the concentration of 125 μg/mL was compared, it was noted that C. reticulata oil was more repellent at this concentration. Copaifera has shown promising activity as a repellent against arthropods owing to the complex chemical composition of its oils.

5.
São Paulo; s.n; 2023. 174 p.
Thesis in Portuguese | LILACS | ID: biblio-1444793

ABSTRACT

A agricultura urbana é uma prática milenar e sua origem está atrelada a técnicas territoriais de combate à fome em épocas de crise e guerras. As hortas urbanas passaram por épocas de apagamento ou valorização, conforme o contexto histórico vivido. A partir de 1987, com a construção do conceito de desenvolvimento sustentável e a valorização do planejamento territorial para construção de cidade mais equitativas, as hortas urbanas voltam a serem incentivadas. Agora, o ponto chave é a sua característica multifuncional. Ser uma prática multifuncional significa que, além da função de produzir cultivos auxiliando na disponibilidade alimentos in natura nas áreas urbanas, ela também gera impacto positivo em outros setores como da saúde, ambientais e sociais. Para averiguar a potência do impacto da agricultura urbana em uma metrópole, foram investigadas sete hortas urbanas em diferentes pontos da cidade de São Paulo e, através da análise de dados qualitativos e quantitativos, foi possível analisar o papel das hortas urbanas para o acesso a alimentos in natura produzidos de forma sustentável. Ademais estudamos como as hortas urbanas promovem saúde ao usarem seus espaços como ponto de venda dos alimentos cultivados, construído um ambiente alimentar saudável e sustentável.


Urban agriculture is an ancient practice, and its origin is linked to territorial techniques to combat hunger in times of crisis and war. Urban gardens went through eras of erasure or appreciation, depending on the historical context experienced. From 1987 onwards, with the construction of the concept of sustainable development and the appreciation of territorial planning for the construction of more equitable cities, urban gardens were once again encouraged. Now, the key point is its multifunctional features. Being a multifunctional practice means that, in addition to the function of producing crops helping the availability of fresh food in urban areas, it also generates a positive impact on other sectors such as health, environmental and social. In order to ascertain the potency of the impact of urban agriculture in a metropolis, seven urban gardens in different parts of the city of São Paulo were investigated and, through the analysis of qualitative and quantitative data, it was possible to analyze the role of urban gardens in access to food in natura produced sustainably. It was also analyzed how urban gardens promote health by using their spaces as a point of sale for cultivated food, building a healthy and sustainable food environment.


Subject(s)
Urban Agriculture , Diet, Healthy , Sustainable Development , in natura Foods , Food System , Health Promotion
6.
Rev. med. (São Paulo) ; 101(5): e-174402, set-out. 2022.
Article in English, Portuguese | LILACS-Express | LILACS | ID: biblio-1393539

ABSTRACT

Introdução: A pandemia do Coronavírus 2 relacionado à Síndrome Respiratória Aguda Grave (SARS-CoV-2), causador da doença do coronavírus 2019 (COVID-19), que emergiu no final de 2019 em Wuhan, Província de Hubei, China é uma variação da família do Coronavírus que causa infecções respiratórias. Os primeiros Coronavírus humanos foram isolados pela primeira vez em 1937. Objetivo: caracterizar perfil epidemiológico de casos confirmados e manifestações clínicas causadas pelo COVID-19 em um município de pequeno porte no nordeste brasileiro. Metodologia: estudo epidemiológico, descritivo, quantitativo de 564 pacientes confirmados com a doença COVID-19 no município de Poções ­ Bahia. Os dados foram obtidos a partir da plataforma do notifica-SUS e com a análise de prontuários somente dos pacientes que foram a óbito, e presença de sinais/sintomas relacionados a doença causada pelo COVID-19 entre o período de 01 de junho de 2020 a 08 de agosto de 2020. Resultados: A faixa etária mais atingida pela doença do COVID-19 esteve compreendida na faixa etária entre 20 a 39 anos com 40,24% de casos confirmados. Na população de 03 a 19 anos, o número de casos foi inversamente proporcional, tendo menor número de contaminados pelo vírus, 8,48% de casos confirmados, assim, seguidos pelos baixos números de casos em bebês/lactantes com taxa de infecção de baixa de 1,95%. Dentre os pacientes diagnosticados com a referida doença, os principais sintomas relatados foram tosse seca (276 [48,9%]), febre (225 [39,89%]), cefaleia (163 [28,90%]), dor de garganta (152 [26,95%), dispneia (124 [21,98%]), mialgia (107 [18,97%]) e anosmia (101 [17,90%]). Dentre os sintomas apresentados, em (76 [12,94%]) dos pacientes possuíam queixa sintomática do sistema gastrointestinal, dos quais, os principais sinais e sintomas relatados por estes foram diarreia, náusea, vômitos, inapetência, dor abdominal e perda de peso. Dentre os pacientes que evoluíram para óbito no município, os sinais/sintomas presentes eram febre e tosse seca (10 [100%]), dispneia (08 [80%]), (08 [80%]) baixa saturação, (01 [10%]) diarreia e (01 [10%]) apresentou queixa de cefaleia. Ressalta-se que as presenças dos sinais/sintomas supracitados foram associadas nos pacientes que foram a óbito. Conclusão: Dentre os pacientes sintomáticos, a febre e tosse foi a queixa mais presente no estudo desde entre os pacientes com quadro leve da doença, aos com quadro grave. A manifestação gastrointestinal isolada também esteve presente na infecção pelo COVID ­ 19 em pacientes. Deste modo, como uma doença nova e com uma vasta sintomatologia, a infecção pelo novo coronavírus deve ser visualizada sempre como um possível diagnóstico diferencial. [au]


Introduction: The Coronavirus 2 pandemic related to Severe Acute Respiratory Syndrome (SARS-CoV-2), which causes coronavirus disease 2019 (COVID-19), which emerged in late 2019 in Wuhan, Hubei Province, China is a variation of the Coronavirus family that causes respiratory infections. The first human Coronaviruses were isolated for the first time in 1937. Objective: to characterize the epidemiological profile of confirmed cases and clinical manifestations caused by COVID-19 in a small municipality in northeastern Brazil.Methodology: epidemiological, descriptive, quantitative study of 564 patients confirmed with COVID-19 disease in the city of Poções - Bahia. The data were obtained from the notifica-SUS platform and with the analysis of medical records only of patients who died with confirmation of the disease between the period from June 1, 2020 to 08/08/2020. Results: The age group most affected by the COVID-19 disease was between 20 and 39 years old, with 40.24% of confirmed cases. In the population aged 3 to 19 years, the number of cases was inversely proportional, with a lower number of infected with the virus, 8.48% of confirmed cases, thus, followed by the low numbers of cases in babies/infants with a low infection rate. of 1.95%. Among the patients diagnosed with the disease, the main symptoms reported were dry cough (276 [48.9%]), fever (225 [39.89%]), headache (163 [28.90%]), sore throat (152 [26.95%), dyspnea (124 [21.98%]), myalgia (107 [18.97%]) and anosmia (101 [17.90%]). Among the symptoms presented, (76 [12.94%]) of the patients had symptomatic complaints of the gastrointestinal system, of which, the main signs and symptoms reported by them were diarrhea, nausea, vomiting, inappetence, abdominal pain and weight loss. Among the patients who died in the municipality, the signs / symptoms present were fever and dry cough (10 [100%]), dyspnoea (08 [80%]), (08 [80%]) low saturation, (01 [ 10%]) diarrhea and (01 [10%]) complained of an important headache. It is noteworthy that the presence of the aforementioned symptoms was associates in patients who died. Conclusion: Among symptomatic patients, fever and cough was the most common complaint in the study since among patients with mild illness, those with severe symptoms. The isolated gastrointestinal manifestation was also present in COVID-19 infection in patients. Thus, as a new disease and with a wide range of symptoms, infection with the new coronavirus should always be viewed as a possible differential diagnosis. [au]

7.
Ciênc. Saúde Colet. (Impr.) ; 27(8): 3079-3090, ago. 2022. tab, graf
Article in Portuguese | LILACS-Express | LILACS | ID: biblio-1384494

ABSTRACT

Resumo O uso do misoprostol com finalidade abortiva é um fenômeno observado no Brasil desde o final da década de 1980. O medicamento começou a ser utilizado nessa época para autoindução do aborto, quando passou a ser comercializado para o tratamento de úlcera péptica. Seu acesso foi restringido a partir de 1998, porém o fármaco continua sendo comercializado na ilegalidade. O objetivo desse artigo é sintetizar o conhecimento produzido em pesquisas no Brasil sobre o aborto induzido e o uso do misoprostol. Foi realizada uma revisão integrativa de estudos originais feitos no Brasil e publicados em revistas indexadas nas bases SciELO, PubMed e Lilacs. Foram encontrados 68 títulos e incluídos 28 artigos na revisão. A maioria das mulheres que induz a interrupção da gestação é jovem e o faz antes das 15 semanas de gestação. A taxa de utilização do misoprostol variou entre 89% e 36%. Esse medicamento é eficaz para a interrupção da gestação no primeiro trimestre e apresenta baixa taxa de complicações. Contudo, quanto mais vulnerável socialmente a mulher, maiores os riscos para a saúde no processo do abortamento. Conclui-se que a compra do misoprostol como abortivo é facilitada, apesar de proibida, e suas complicações estão associadas ao contexto de vulnerabilidade da gestante.


Abstract The use of misoprostol for abortifacient purposes is a phenomenon observed in Brazil since the late 1980s. The drug started to be used at that time for self-induced abortion, when it began to be commercialized for the treatment of peptic ulcer. Its access was restricted from 1998 onwards, but the drug continues to be commercialized illegally. The objective of this article is to summarize the knowledge produced by research in Brazil about induced abortion and the use of misoprostol. An integrative review of original studies carried out in Brazil and published in journals indexed in SciELO, PubMed and Lilacs databases was performed. The search found 68 titles, and 28 articles were included in the review. Most women who induced pregnancy interruption were young and did it before 15 gestational weeks. The rate of misoprostol use ranged from 89% to 36%. This drug is effective for terminating pregnancy in the first trimester and has a low rate of complications. However, the more socially vulnerable the woman is, the greater are the health risks in the abortion process. The conclusion is that the purchase of misoprostol as an abortifacient is facilitated, despite it being prohibited, and its complications are associated with the context of vulnerability of the pregnant woman.

8.
Res Vet Sci ; 150: 107-114, 2022 Dec 05.
Article in English | MEDLINE | ID: mdl-35809414

ABSTRACT

Canine pituitary-dependent hypercortisolism (PDH) management with trilostane usually demands lifelong therapy. The greater the dose needed, the greater the risk of side effects. Selegiline therapy has been previously described but not commonly used for PDH treatment. The present work aimed to assess the efficacy of selegiline and trilostane combined therapy for canine PDH treatment. Fifteen client-owned dogs diagnosed with spontaneous PDH were enrolled. The patients were treated with trilostane (Tri group, n = 8, initial dose of 0.5 mg/kg, PO, q12h), or with trilostane and selegiline (Tri + Sel group, n = 7, initial trilostane dose of 0.5 mg/kg, PO, q12h and selegiline 1 mg/kg, PO, q24h). Dogs underwent clinical examination, serum biochemical analysis, urinalysis, abdominal ultrasound, and eACTH and post-ACTH cortisol measurements on treatment days zero (D0), 30 (D30), 90 (D90), and 180 (D180). There was a lack of adverse effects due to the combined therapy. Both groups showed a similar clinical response and lower post-ACTH cortisol levels at the study's end. There was no significant difference in trilostane dosage at D180 between groups. There was no documented increase in either right or left adrenal gland thickness in the Tri + Sel group in contrast with patients in the Tri group. However, there was no statistical difference between the groups regarding eACTH at D0 and D180. Patients in the Tri + Sel group achieved better serum triglycerides control at the end of the study. The association of selegiline with trilostane might be a feasible therapy for canine PDH; however, its eventual advantages need larger studies.


Subject(s)
Cushing Syndrome , Dog Diseases , Pituitary ACTH Hypersecretion , Adrenocorticotropic Hormone/therapeutic use , Animals , Cushing Syndrome/veterinary , Dihydrotestosterone/analogs & derivatives , Dog Diseases/drug therapy , Dogs , Hydrocortisone , Pilot Projects , Pituitary ACTH Hypersecretion/drug therapy , Pituitary ACTH Hypersecretion/veterinary , Selegiline/therapeutic use
9.
Cien Saude Colet ; 27(8): 3079-3090, 2022 Aug.
Article in Portuguese, English | MEDLINE | ID: mdl-35894320

ABSTRACT

The use of misoprostol for abortifacient purposes is a phenomenon observed in Brazil since the late 1980s. The drug started to be used at that time for self-induced abortion, when it began to be commercialized for the treatment of peptic ulcer. Its access was restricted from 1998 onwards, but the drug continues to be commercialized illegally. The objective of this article is to summarize the knowledge produced by research in Brazil about induced abortion and the use of misoprostol. An integrative review of original studies carried out in Brazil and published in journals indexed in SciELO, PubMed and Lilacs databases was performed. The search found 68 titles, and 28 articles were included in the review. Most women who induced pregnancy interruption were young and did it before 15 gestational weeks. The rate of misoprostol use ranged from 89% to 36%. This drug is effective for terminating pregnancy in the first trimester and has a low rate of complications. However, the more socially vulnerable the woman is, the greater are the health risks in the abortion process. The conclusion is that the purchase of misoprostol as an abortifacient is facilitated, despite it being prohibited, and its complications are associated with the context of vulnerability of the pregnant woman.


O uso do misoprostol com finalidade abortiva é um fenômeno observado no Brasil desde o final da década de 1980. O medicamento começou a ser utilizado nessa época para autoindução do aborto, quando passou a ser comercializado para o tratamento de úlcera péptica. Seu acesso foi restringido a partir de 1998, porém o fármaco continua sendo comercializado na ilegalidade. O objetivo desse artigo é sintetizar o conhecimento produzido em pesquisas no Brasil sobre o aborto induzido e o uso do misoprostol. Foi realizada uma revisão integrativa de estudos originais feitos no Brasil e publicados em revistas indexadas nas bases SciELO, PubMed e Lilacs. Foram encontrados 68 títulos e incluídos 28 artigos na revisão. A maioria das mulheres que induz a interrupção da gestação é jovem e o faz antes das 15 semanas de gestação. A taxa de utilização do misoprostol variou entre 89% e 36%. Esse medicamento é eficaz para a interrupção da gestação no primeiro trimestre e apresenta baixa taxa de complicações. Contudo, quanto mais vulnerável socialmente a mulher, maiores os riscos para a saúde no processo do abortamento. Conclui-se que a compra do misoprostol como abortivo é facilitada, apesar de proibida, e suas complicações estão associadas ao contexto de vulnerabilidade da gestante.


Subject(s)
Abortifacient Agents, Nonsteroidal , Abortifacient Agents , Abortion, Induced , Misoprostol , Abortion, Criminal , Female , Humans , Pregnancy
10.
J Biomol Struct Dyn ; 40(5): 2204-2216, 2022 03.
Article in English | MEDLINE | ID: mdl-33146078

ABSTRACT

Glioblastoma is an aggressive primary tumor of the central nervous system (CNS). Is the most aggressive among infiltrative gliomas arising from the CNS. This tumor has low patient survival rate and several studies aiming at developing new drugs have increased. Patients with this cancer type face significant morbidity and mortality. This study evaluated the antineoplastic activity of synthetic chalcones (3a-3f) using in vitro glioblastoma models and molecular modeling. Cytotoxicity assay showed that Astrocitoma Hospital Ofir Loyola No 1 (AHOL1) and Uppsala 87 neoplastic glioblastoma lines (U87) cellular viability were significantly reduced compared to Healthy human fibroblasts cell lines (AN27) when exposed to chalcones. Interaction with the serine amino acid was present in the most promising and the reference binder docking, suggesting its importance inhibiting cell growth. Comparative analysis between the reference ligands and the molecules showed that the amino acid LYS352 present in all fittings, suggesting that this is the main amino acid for interaction with tubulin and are consistent with those in cytotoxicity assay, suggesting antineoplastic potential in glioblastoma. Long trajectory molecular dynamics studies were also carried out in order to investigate stability and conformations amongst the chalcones bound tubulin as well, in comparison to doxorubicin (here used as control), however future studies are needed to further assess the mechanism of inhibition of chalcones used in this investigation.Communicated by Ramaswamy H. Sarma.


Subject(s)
Antineoplastic Agents , Chalcones , Antineoplastic Agents/chemistry , Antineoplastic Agents/pharmacology , Cell Line, Tumor , Chalcones/chemistry , Chalcones/pharmacology , Humans , Molecular Docking Simulation , Molecular Dynamics Simulation , Molecular Structure , Structure-Activity Relationship
11.
BioSC. (Curitiba, Impresso) ; 80(Supl.1): 36-39, 20220000.
Article in Portuguese | LILACS | ID: biblio-1417803

ABSTRACT

Casos de infecção pelo coronavírus surgiram em 2019 e fatores de risco podem conduzir complicações, entre elas, a coinfecção viral podendo comprometer a resposta imunológica e interferir no prognóstico. Objetivos: Analisar estudos sobre coinfecção viral na COVID-19, avaliando prevalência e correlação com seu prognóstico. Métodos: Foram realizadas buscas em bases de dados utilizando os descritores: SARS-COV 2, coinfecção, vírus, coronavírus, e COVID-19. Resultados: Foram selecionados 12 artigos com os seguintes vírus: influenza, HIV e herpes. Apesar da coinfecção com influenza ser pouco prevalente, seu reconhecimento permitiu compreender diferentes manifestações clínicas e tratamento adequado. Já a coinfecção com HIV revelou que pacientes com AIDS não tratada tiveram pior prognóstico. Por fim, a coinfecção com herpes resultou em reativação, com os seguintes tipos associados: HSV-1, HSV-3, EBV, CMV e HHV-6. Conclusão: Não há evidências científicas suficientes para afirmar que a coinfecção com SARS-COV 2 com outros vírus traz pior prognóstico para COVID-19, sendo necessários mais estudos sobre tais interações


Cases of coronavirus infection emerged in 2019 and risk factors can lead to complications, including viral coinfection, which can compromise the immune response and interfere with prognosis. Objectives: To analyze studies on viral coinfection in COVID-19, evaluating prevalence and correlation with its prognosis. Methods: Database searches were performed using the descriptors: SARS-COV 2, coinfection, virus, coronavirus, and COVID-19. Results: Twelve articles with the following viruses were selected: influenza, HIV and herpes. Although coinfection with influenza is not very prevalent, its recognition made it possible to understand different clinical manifestations and appropriate treatment. Coinfection with HIV revealed that patients with untreated AIDS had a worse prognosis. Finally, coinfection with herpes resulted in reactivation, with the following types associated: HSV-1, HSV-3, EBV, CMV, and HHV-6. Conclusion: There is not enough scientific evidence to state that co-infection with SARS-COV 2 with other viruses brings a worse prognosis for COVID-19, and further studies on such interactions are needed


Subject(s)
Humans , Prognosis , Coinfection , COVID-19 , HIV , Coronavirus , Herpesvirus 6, Human , Herpesvirus 4, Human , Cytomegalovirus , SARS-CoV-2 , Herpes Simplex , Herpes Zoster
12.
Comp Immunol Microbiol Infect Dis ; 75: 101624, 2021 Apr.
Article in English | MEDLINE | ID: mdl-33609989

ABSTRACT

Study's aims were to characterize subclinical bacteriuria (SB) and sporadic bacterial cystitis (SBC) in dogs with spontaneous hypercortisolism (HC). Prospective cross-sectional design divided patients as newly diagnosed (n = 27), poorly controlled (n  = 21), well controlled (n  = 34), and controls (n  = 19). Urine culture positive results were identified by MALDI-TOF and submitted to antibiogram. Escherichia coli was the most common microorganism (36%). The majority of positive cultures in HC were SB (12.2%). All 4.1% SBC cases were in well controlled HC cases. Bacteriuria correlated with low urine specific gravity and low lymphocyte count. HC degree of control correlated with leukocyturia. SB/SBC cases were treated based in antimicrobial susceptibility leading to microbiological cure in 75% of HC cases. Persistent infections occurred only in SB cases, all by E. coli which became more resistant. SB/SBC prevalence in canine HC is actually lower. Further evidence for current ISCAID guideline contraindication for SB treatment due to HC were provided.


Subject(s)
Bacteriuria , Cushing Syndrome , Cystitis , Dog Diseases , Urinary Tract Infections , Animals , Bacteriuria/epidemiology , Bacteriuria/veterinary , Cross-Sectional Studies , Cushing Syndrome/veterinary , Cystitis/epidemiology , Cystitis/veterinary , Dog Diseases/drug therapy , Dog Diseases/epidemiology , Dogs , Escherichia coli , Prospective Studies , Urinary Tract Infections/veterinary
13.
Rev Bras Epidemiol ; 24: e210002, 2021.
Article in Portuguese, English | MEDLINE | ID: mdl-33439940

ABSTRACT

AIM: The present work aims to evaluate the performance of hospitals participating on the National Program for the Evaluation of Health Services (Programa Nacional de Avaliação de Serviços de Saúde - PNASS, 2015-2016). METHODS: This is a descriptive cross-sectional quantitative study, which measured the performance of hospitals participating in the program, using data from the first PNASS 2015-2016 evaluation instrument. The processes evaluation questionnaire used in hospitals had 102 items, 17 criteria, grouped into four blocks or dimensions. RESULTS: A total of 1,681 hospitals was evaluated. The average score for each block was: Organizational management (64); technical and logistical support for care provision (73); health care and care management (64); specific services/units (72). Regarding the administrative sphere, the best average performance was of the federal sphere, followed by the state and municipal ones. The hospitals located in the Southern and Southeastern regions presented the best performance (73), followed by the Midwestern (62.7), Northeastern (61.2), and Northern (58.5) regions. CONCLUSION: The hospitals that perform highly complex procedures, just like those large and special ones, obtained a better performance. Public federal hospitals, with municipal management, also had the best results, as well as hospitals from the Southern and Southwestern regions of the country.


OBJETIVO: O estudo tem como objetivo avaliar o desempenho dos hospitais que participaram do Programa Nacional de Avaliação de Serviços de Saúde (PNASS 2015-2016). MÉTODOS: Estudo descritivo transversal quantitativo, que buscou mensurar o desempenho dos hospitais que participaram do programa com base nos dados do primeiro instrumento avaliativo do PNASS 2015-2016. O questionário de avaliação de processos aplicado aos hospitais contou com 102 itens, 17 critérios, agrupados em quatro blocos ou dimensões. RESULTADOS: Participaram 1.681 hospitais. O escore médio por bloco foi: gestão organizacional (64), apoio técnico e logístico para produção de cuidado (73), gestão da atenção à saúde e do cuidado (64) e serviços/unidades específicas (72). Com relação à esfera administrativa, o melhor desempenho médio foi obtido pela esfera federal, seguido da estadual e da municipal. Os hospitais localizados no Sul e Sudeste obtiveram o melhor desempenho (73,0), seguido do Centro-Oeste (62,7), Nordeste (61,2) e Norte (58,5). CONCLUSÃO: Os hospitais que realizam procedimentos de alta complexidade, assim como os de grande porte e especiais, obtiveram melhor desempenho. Hospitais públicos federais, de gestão municipal, também alcançaram os melhores resultados, bem como os hospitais do Sul e Sudeste do país.


Subject(s)
Health Services Research , Hospitals , Brazil , Cross-Sectional Studies , Humans
14.
Rev. bras. epidemiol ; 24: e210002, 2021. tab
Article in English, Portuguese | LILACS | ID: biblio-1156020

ABSTRACT

RESUMO: Objetivo: O estudo tem como objetivo avaliar o desempenho dos hospitais que participaram do Programa Nacional de Avaliação de Serviços de Saúde (PNASS 2015-2016). Métodos: Estudo descritivo transversal quantitativo, que buscou mensurar o desempenho dos hospitais que participaram do programa com base nos dados do primeiro instrumento avaliativo do PNASS 2015-2016. O questionário de avaliação de processos aplicado aos hospitais contou com 102 itens, 17 critérios, agrupados em quatro blocos ou dimensões. Resultados: Participaram 1.681 hospitais. O escore médio por bloco foi: gestão organizacional (64), apoio técnico e logístico para produção de cuidado (73), gestão da atenção à saúde e do cuidado (64) e serviços/unidades específicas (72). Com relação à esfera administrativa, o melhor desempenho médio foi obtido pela esfera federal, seguido da estadual e da municipal. Os hospitais localizados no Sul e Sudeste obtiveram o melhor desempenho (73,0), seguido do Centro-Oeste (62,7), Nordeste (61,2) e Norte (58,5). Conclusão: Os hospitais que realizam procedimentos de alta complexidade, assim como os de grande porte e especiais, obtiveram melhor desempenho. Hospitais públicos federais, de gestão municipal, também alcançaram os melhores resultados, bem como os hospitais do Sul e Sudeste do país.


ABSTRACT: Aim: The present work aims to evaluate the performance of hospitals participating on the National Program for the Evaluation of Health Services (Programa Nacional de Avaliação de Serviços de Saúde - PNASS, 2015-2016). Methods: This is a descriptive cross-sectional quantitative study, which measured the performance of hospitals participating in the program, using data from the first PNASS 2015-2016 evaluation instrument. The processes evaluation questionnaire used in hospitals had 102 items, 17 criteria, grouped into four blocks or dimensions. Results: A total of 1,681 hospitals was evaluated. The average score for each block was: Organizational management (64); technical and logistical support for care provision (73); health care and care management (64); specific services/units (72). Regarding the administrative sphere, the best average performance was of the federal sphere, followed by the state and municipal ones. The hospitals located in the Southern and Southeastern regions presented the best performance (73), followed by the Midwestern (62.7), Northeastern (61.2), and Northern (58.5) regions. Conclusion: The hospitals that perform highly complex procedures, just like those large and special ones, obtained a better performance. Public federal hospitals, with municipal management, also had the best results, as well as hospitals from the Southern and Southwestern regions of the country.


Subject(s)
Humans , Health Services Research , Hospitals , Brazil , Cross-Sectional Studies
15.
Belo Horizonte; s.n; 2021. 106 p.
Thesis in Portuguese | LILACS, InstitutionalDB, Coleciona SUS | ID: biblio-1427292

ABSTRACT

RESUMO Introdução: Avaliar o desempenho da Gestão Organizacional dos Serviços Hospitalares do Brasil é relevante, pois as ações de gestão organizacional proporcionam adequado funcionamento, planejamento e organização aos hospitais, bem como, proveem condições físicas, tecnológicas, materiais e humanas que influenciam nos resultados assistenciais. Considerando o grande número de hospitais que compõe o Sistema Único de Saúde e a importância destes serviços na assistência na saúde população, torna-se relevante avaliá-los sob ótica da gestão organizacional. Objetivo: Avaliar o desempenho da Gestão Organizacional dos Serviços Hospitalares no Brasil. Método: Estudo transversal que utilizou dados secundários do Programa Nacional de Avaliação dos Serviços de Saúde 2015-2016 para avaliar o Desempenho da Gestão Organizacional de 1665 hospitais do Brasil a partir de 30 itens de verificação referentes a Gestão de contratos, Pessoas, Informação, Planejamento e Organização, Modelo Organizacional, que compuseram um escore de avaliação dos hospitais. O Desempenho foi avaliado segundo os indicadores porte hospitalar, nível de complexidade, esfera administrativa, tipo de gestão e região do país. Verificou-se a associação entre o Desempenho da Gestão Organizacional dos hospitais com indicadores Taxa de Ocupação, Média de Permanência, Taxa de Mortalidade Hospitalar e Valor Médio da AIH. Utilizou-se a Análise de Componentes Principais para verificar a relação de dependências entre as variáveis e explicar a variabilidades dos dados. Foi estimado o modelo de regressão logística ajustado para verificar as variáveis que melhor explicam o Desempenho da Gestão Organizacional. Resultados: A média de Desempenho da Gestão Organizacional dos hospitais foi de 63,83. A avaliação por critério obteve-se os seguintes resultados: Gestão da Informação (77,59), Gestão de Pessoas (61,96), Gestão de Contratos (61,71), Modelo Organizacional (61,64), Planejamento e Organização (56,45). Os melhores resultados foram verificados nos hospitais da região Sul, nível de Complexidade 8, acima de 150 leitos, Esfera Administrativa Público Federal e Gestão Estadual. Na análise de regressão logística as variáveis que mais explicam o Desempenho da Gestão Organizacional são: Taxa de Ocupação (p<9.87E-09), Porte hospitalar (p<4.49E-10), gestão municipal (p<0.004), Nível Hierárquico Nível 7 (p<0.042), Nível 8 (p<0.022) região Sul (p<0.004), Sudeste (p<0.002). Conclusão: O estudo mostra que o PNASS é um potente e qualificado instrumento de avaliação dos hospitais. Evidenciou-se lacunas importantes na Gestão Organizacional dos Hospitais frente aos critérios dos PNASS. Aponta também para a relação de escala e eficiência. Além disto, o estudo reforça a desigualdade regional com concentração de hospitais nas regiões Sul e Sudeste em termos quantitativos e qualitativos, além de demostrar a necessidade de aprofundamento sobre a gestão dos hospitais de gestão municipal dada a insuficiência apontada neste estudo.


ABSTRACT Introduction: To evaluate the performance of the Organizational Management of Hospital Services in Brazil is relevant because the organizational management actions provide adequate operation, planning, and organization to hospitals as well as physical, technological, material, and human conditions that influence the care results. Considering the large number of hospitals that are part of the Brazilian Unified Health System and the importance of these services in the population health care, it becomes relevant to evaluate them from an organizational management standpoint. Objective: To evaluate the performance of the Organizational Management of Hospital Services in Brazil. Method: Cross-sectional study that used secondary data from the 2015-2016 National Health Services Evaluation Program to evaluate the Organizational Management Performance of 1665 hospitals in Brazil from 30 verification items referring to Contract Management, People, Information, Planning and Organization, Organizational Model, which constituted an evaluation score of the hospitals. The Performance was evaluated according to the indicators: hospital size, level of complexity, administrative system, type of management and region of the country. It was verified the association between Performance of Organizational Management of hospitals with indicators such as: Occupancy Rate, Average Length of Stay, Hospital Mortality Rate and Average Value of Hospital Admission Rate. We used Main Components Analysis in order to verify the dependent relationship among variables and to explain data variability. The adjusted logistic regression model was estimated to verify the variables that best explain the Organizational Management Performance. Results: The average of Organizational Management Performance of the hospitals was 63.83. In the evaluation by criteria the following results were obtained: Information Management (77.59), People Management (61.96), Contract Management (61.71), Organizational Model (61.64), Planning and Organization (56.45). The best results were seen in hospitals in the South region, Complexity level 8, above 150 beds, Federal Public Administrative System and State Management. In the logistic regression analysis the variables that most explain Organizational Management Performance are: Occupancy Rate (p<9.87E-09), Hospital Size (p<4.49E-10), Municipal Management (p<0.004), Hierarchical Level- Level 7 (p<0.042), Level 8 (p<0.022) Southern region (p<0.004), Southeast (p<0.002). Conclusion: The study shows that the PNASS is a powerful and qualified instrument for evaluating hospitals. Important gaps in the Organizational Management of Hospitals in relation to the PNASS criteria were highlighted. It also points to the relationship between scale and efficiency. Moreover, the study reinforces the regional inequality by concentrating hospitals in the South and Southeast regions in quantitative and qualitative terms, besides demonstrating the need for further study on the management of hospitals under municipal management given its insufficiency indicated in this study.


Subject(s)
Humans , Male , Female , Health Evaluation , Health Services Administration , Health Management , Hospital Administration , National Health Programs , Ancillary Services, Hospital , Hospital Mortality , Hospitals , Length of Stay
16.
Estilos clín ; 25(2): 322-338, maio-ago. 2020.
Article in Portuguese | LILACS, Index Psychology - journals | ID: biblio-1286390

ABSTRACT

O presente artigo é uma pesquisa de revisão de literatura, com o objetivo de identificar algumas das principais hipóteses explicativas sobre o autismo na psicanálise e as suas contribuições no que diz respeito ao seu tratamento. A busca foi realizada nas bibliotecas virtuais Pepsic e Scielo, sendo incluídos artigos escritos em língua portuguesa, publicados no período de 2012 a 2017. Vinte e três artigos foram selecionados e analisados, buscando- se identificar as hipóteses psicanalíticas sobre o autismo, propostas de tratamento, objetivos, métodos, principais resultados e conclusões. Constatamos que os autores mais citados foram Jacques Lacan, seguido por Jean-Claude Maleval, Marie Christine Laznik, Alfredo Jerusalinsky e Maria Cristina Kupfer, todos autores mais ou menos identificados ao referencial lacaniano. No que diz respeito às hipóteses explicativas, encontramos hipóteses sobre a existência de alguma falha ou de algo que não se completa na constituição psíquica do autista. Sobre o diagnóstico do autismo, destacamos os riscos dos diagnósticos precoces e normativos, considerando que a constituição psíquica da criança ainda está em formação. E, finalmente, sobre a possibilidade de tratamento, os artigos indicam a necessidade de respeitar a singularidade da pessoa autista e sua forma de estar no mundo, buscando uma aproximação delicada e não invasiva.


Este artículo es una investigación de revisión de literatura, con el objetivo de identificar algunas de las principales hipótesis explicativas sobre el autismo en psicoanálisis y sus contribuciones respecto a su tratamiento. La búsqueda fue realizada en las bibliotecas virtuales Pepsic y Scielo, incluyendo los artículos escritos en lengua portuguesa y publicados entre 2012 y 2017. Veintitrés artículos fueron seleccionados y analizados, buscando identificar las hipótesis psicoanalíticas sobre el autismo, propuestas de tratamiento, objetivos, métodos, principales resultados y conclusiones. Los resultados apuntan que los autores más citados fueron Jacques Lacan, seguido de Jean-Claude Maleval, Marie Christine Laznik, Alfredo Jerusalinsky y Maria Cristina Kupfer, todos ellos más o menos identificados con el referencial lacaniano. En lo que se refiere a las hipótesis explicativas, encontramos hipótesis sobre la existencia de alguna falla o algo incompleto en la constitución psíquica del autista. Sobre el diagnóstico de autismo, destacamos los riesgos de los diagnósticos tempranos y normativos, considerando que la constitución psíquica del niño todavía está en formación. Y, finalmente, sobre la posibilidad de tratamiento, los artículos indican la necesidad de respetar la singularidad de la persona autista y su forma de estar en el mundo, privilegiando un enfoque no invasivo.


This article is a research literature review aiming to identify some of the main explanatory hypotheses on autism in psychoanalysis and their contributions related to its treatment. The search was carried out in Pepsic and Scielo virtual libraries including articles written in Portuguese, published among 2012-2017 period. Twenty- three articles were selected and analyzed with the purpose of identifying the psychoanalytic hypotheses on autism, treatment proposals, objectives, methods, main results and conclusions. Results showed that the most cited authors were Jacques Lacan, followed by Jean-Claude Maleval, Marie Christine Laznik, Alfredo Jerusalinsky and Maria Cristina Kupfer, who are supported by the Lacanian framework. Regarding the explanatory hypotheses, assumptions about the existence of some failure or something that is not completed in the psychic constitution of the autistic were found, leading to highlight the risks of early and normative diagnoses. And, finally, about the possibility of treatment, the articles point out the need of respecting the uniqueness of the autistic person and his way of being in the world, in search of a delicate and non-invasive approach.


Subject(s)
Humans , Autistic Disorder/diagnosis , Autistic Disorder/psychology , Autistic Disorder/therapy , Psychoanalysis/history
17.
Estud. interdiscip. envelhec ; 25(1): 7-20, mar.2020. ilus
Article in Portuguese | LILACS, Index Psychology - journals | ID: biblio-1415704

ABSTRACT

Esta pesquisa tem como objetivo analisar as possíveis contribuições da autoria digital, por meio de infográficos, para um grupo de idosos participantes de um curso de inclusão digital. O envelhecimento da população e o aumento do uso das tecnologias digitais são realidades atuais. Dessa forma, percebe-se a necessidade de propor situações que permitam aos idosos a experiência frente aos recursos digitais a fim de que eles sejam incluídos tecnologicamente. A pesquisa teve uma abordagem qualitativa e quantitativa. Participaram do estudo 25 idosos de um projeto de inclusão digital realizado em uma universidade pública no sul do Brasil. Para a coleta de dados, utilizou-se um questionário contendo perguntas abertas e fechadas, observação participante e análise de infográficos construídos. Os depoimentos dos participantes viabilizaram observar uma melhoria na autoestima dos idosos pela possibilidade de desenvolver em infográficos por meio da autoria digital. A partir da análise de dados, também se observou que, apesar das dificuldades apresentadas com a utilização da ferramenta digital, a maioria dos participantes afirmou que pretende utilizar a ferramenta novamente. Tais evidências apontam que a realização desse tipo de atividade pode constituir-se em uma oportunidade de inclusão social por meio da inclusão digital.(AU)


The goal of this research is to analyze the possible contributions of digital authorship, through infographics of a group of older participants of a digital inclusion course. Population aging and the increasing use of digital technologies are a current reality. Thus, we noticed the need to propose situations that allow older adults to experience digital resources so that they can be included technologically. The research took qualitative and quantitative approaches. Twenty-five older adults took part in a digital inclusion project carried out at a public university in southern Brazil. For data collection, a questionnaire containing open and closed questions, participant observation and analysis of the built infographics were used. The participants' statements made it possible to observe an improvement in the self-esteem of the older adults due to the possibility of developing infographics through digital authorship. From the data analysis, it was also noted that, despite the difficulties about the use of a digital tool, most participants stated that they want to use the tool again. Such evidences indicate that the accomplishment of this type of activity can be an opportunity for social inclusion through digital inclusion.(AU)


Subject(s)
Authorship , Aged , Education, Continuing , Digital Technology , Learning
18.
Psico (Porto Alegre) ; 51(3): 36529, 2020.
Article in English | LILACS | ID: biblio-1147686

ABSTRACT

Online psychotherapy was recognized by the Federal Council of Psychology Resolution n. 11/2018. With the official recognition of this practice, many professionals raised questions about its equivalence to face-to-face psychotherapy and the possible need of technical adaptations. Considering the lack of research on this theme, this study aimed to explore how psychodynamic/psychoanalytical psychotherapists perceive their own practice in online settings, including technical and relational aspects of the therapeutic process, in comparison to their experience in face-to-face treatments. This is a qualitative study with an exploratory approach. Eight psychologists responded to videoconference interviews. The interviews were audiotaped, fully transcribed, and analyzed by thematic analysis. Results were organized in two major themes (online psychotherapy practice and technique and psychodynamic process in online psychotherapy). Main results indicate online psychodynamic psychotherapy has many distinctive features (e.g. relying on quality of internet connection, fostering focal process, occurring in a more vulnerable setting, and eliciting a different pattern of communication) that require adaptation from the-rapist. Implication of findings to psychotherapy training and practice are discussed.


A psicoterapia online foi reconhecida pela Resolução nº 11/2018 do Conselho Federal de Psicologia. Com o reconhecimento oficial dessa prática, profissionais levantaram questões sobre sua equivalência à psicoterapia presencial e sobre a possível necessidade de adaptações técnicas. Considerando a falta de pesquisas sobre esse tema, este estudo teve como objetivo explorar como os psicoterapeutas psicodinâmicos percebem sua prática clínica on-line, incluindo os aspectos técnicos e relacionais do processo terapêutico, em comparação com a experiência em tratamentos face a face. Este é um estudo qualitativo, com abordagem exploratória. Oito psicólogos foram entrevistados em videoconferência. As entrevistas foram gravadas em áudio, transcritas integralmente, e analisadas por análise temática. Os resultados foram organizados em dois grandes temas (prática da psicoterapia online e técnica e processo psicodinâmico na psicoterapia online). Os principais resultados indicam que a psicoterapia psicodinâmica on-line tem muitas características específicas (por exemplo, depender da qualidade da conexão de Internet, promover um processo focal, ocorrer em um ambiente mais vulnerável e eliciar outro padrão de comunicação) que exigem adaptação do terapeuta. As implicações dos achados para o treinamento e prática da psicoterapia são discutidas.


La psicoterapia online fue reconocida por la Resolución no. 11/2018 del Consejo Federal de Psicología. Con el reconocimiento oficial de esta práctica, los profesionales plantearon preguntas sobre su equivalencia a la psicoterapia presencial y sobre la posible necesidad de adaptaciones técnicas. Teniendo en cuenta la falta de investigaciones sobre este tema, este estudio tuvo como objetivo explorar cómo los psicoterapeutas psicodinámicos perciben su práctica clínica online, incluidos los aspectos técnicos y relacionales del proceso terapéutico, en comparación con la experiencia en tratamientos cara a cara. Este es un estudio cualitativo con un enfoque exploratorio. Ocho psicólogos fueron entrevistados en videoconferencia. Las entrevistas fueron grabadas en audio y analizadas por análisis temático. Los resultados se organizaron en dos temas generales (práctica de psicoterapia online y técnica y proceso psicodinámico en psicoterapia online). Los principales resultados indican que una psicoterapia psicodinámica online tiene muchas características distintivas (por ejemplo, confiar en la calidad de conexión de Internet, promover un proceso focal, ocurrir en un ambiente más vulnerable, y provocar otro modo de comunicación) que exige la adaptación del terapeuta. Se discuten las implicaciones de los hallazgos para el entrenamiento y la práctica de psicoterapia.


Subject(s)
Psychology, Clinical , Psychotherapy , Internet , Psychology
19.
Ciênc. rural (Online) ; 50(12): e20200379, 2020. tab, graf
Article in English | LILACS-Express | LILACS | ID: biblio-1133230

ABSTRACT

ABSTRACT: Hypercortisolism is a common endocrinopathy in dogs; however, in a few cases, bilateral functional adrenocortical adenomas cause spontaneous disease, and thrombotic events are considered uncommon complications. The aim of this report was to describe a case of bilateral adrenocortical adenoma in a dog with hyperadrenocorticism associated with distal aortic and iliac thrombosis, with emphasis on clinical and pathological aspects. A 15-year-old spayed female Dachshund with a previous clinical history of hyperadrenocorticism presented with acute bilateral hindlimb paraparesis. A vertebral thoracolumbar radiography was performed and did not present any evidence of intervertebral disk disease or vertebral abnormalities; however, abdominal ultrasound and vascular Doppler evaluation revealed bilateral adrenal enlargement in addition to an aortic and external iliac artery thrombus. The animal was euthanized. At necropsy, both adrenal glands were enlarged by well-demarcated neoplastic nodules in the parenchyma, and a thrombus caudal to the abdominal aorta bifurcation within the external iliac arteries that extended to the left external iliac artery was noted. Histological evaluation revealed a well-differentiated neoplastic proliferation of cortical epithelial cells, consistent with bilateral adenoma, and muscular necrosis in the pelvic limbs was also observed. Bilateral functional adrenocortical adenoma; although, very rare, should be considered as a cause of hypercortisolism, and aortic thrombosis in dogs should be considered as a possible consequence.


RESUMO: Hipercortisolismo é uma endocrinopatia comum em cães, no entanto, apenas em poucos casos adenomas adrenocorticais funcionais bilaterais são a causa de doença espontânea, e eventos trombóticos são considerados complicações incomuns. O objetivo deste relato foi descrever um caso de adenoma adrenocortical bilateral em um cão com hiperadrenocorticismo associado a trombose aórtica distal e ilíaca, com ênfase nos aspectos clínicos e patológicos. Um cão, Dachshund, fêmea castrada, de 15 anos, com histórico clínico prévio de hiperadrenocorticismo, apresentou paraparesia aguda dos membros posteriores. Foi realizada radiografia toracolombar vertebral, a qual não mostrou nenhuma evidência de doença do disco intervertebral ou anormalidades vertebrais; no entanto, ultrassonografia abdominal e Doppler vascular revelaram um trombo na aorta e artéria ilíaca externa, e adrenomegalia bilateral. O animal foi submetido à eutanásia. Na necropsia, ambas as adrenais estavam distendidas por nódulos neoplásicos bem delimitados no parênquima e notou-se um trombo caudalmente à bifurcação da aorta abdominal às artérias ilíacas externas, estendendo-se à ilíaca externa esquerda. Na avaliação histológica observou-se proliferação neoplásica bem diferenciada de células epiteliais corticais, consistente com adenoma bilateral; também foi observada necrose muscular nos membros pélvicos. O adenoma adrenocortical funcional bilateral, embora muito raro, deve ser considerado uma causa de hipercortisolismo, e a trombose aórtica em cães deve ser considerada uma possível consequência.

20.
Transfus Med Hemother ; 46(4): 276-281, 2019 Aug.
Article in English | MEDLINE | ID: mdl-31700510

ABSTRACT

Twin hematopoietic chimera in humans is a phenomenon that was discovered accidentally and the prevalence of which remains unclear. The resolution of chimera cases requires studying family medical records, data analysis, and investigations of hematopoietic cells and cells from other tissues. The interactions among ABO, Lewis, and secretor histo-blood group systems are explored to resolve cases of hematopoietic chimera. Here we report a rare case of hematopoietic chimera where twins present a mixed field reaction in the ABO, Rh, and Kidd red blood cell phenotyping. Using red blood cells separated from the mixed field as well as molecular approaches and investigations of family members, we identify inconsistent genotypes with the Mendelian inheritance pattern when comparing the peripheral blood with the buccal epithelium of the male twin and his twin sister. Analysis of the ABO, Lewis, and secretor phenotypes, and genomic DNA from buccal epithelium showed the genotypes ABO*A1.01/ABO*B.01 and FUT2*01N.02/ FUT2*01N.02 in the male twin and the genotypes ABO*O.01.01/ABO*O.01.02 and FUT2*01/FUT2*01 in the female twin. The results of the HLA-DRB1 genotyping showed inconsistency between the male and his twin sister. We conclude that the serological analyses combined with molecular approaches used in this study are good tools to resolve cases of hematopoietic chimera.

SELECTION OF CITATIONS
SEARCH DETAIL
...