Synthesis of palladium-decorated defective tungsten oxide heterostructures with enhanced photothermal catalytic activity for hydrodeoxygenation of vanillin.

The selective hydrodeoxygenation (HDO) of sustainable lignocellulosic biomass plays a pivotal role in the conversion of biomass into high-value fuels and chemicals. Nevertheless, HDO for biomass upgrading always demands high temperatures and high hydrogen (H2) pressure. Photothermal catalysis has been recognized as an effective approach for boosting chemical reactions under mild conditions while maintaining superior selectivity. Herein, we report the design of palladium-decorated defective tungsten oxide (Pd/WO3-x) catalysts with enhanced photothermal catalytic performances for the efficient HDO of vanillin. Pd/WO3-x nanoflowers have been synthesized through a solvothermal/in-situ reduction two-step strategy, and they exhibit notable photoabsorption in a wide range (200-1100 nm), high photothermal conversion and efficient charge separation efficiency. Under simulated sunlight irradiation (0.3 W cm-2), Pd/WO3-x exhibits a maximum vanillin conversion up to 86.8 % with a 2-methoxy-4-methylphenol (MMP) selectivity of 100 %, which is obviously higher than that (vanillin conversion = 33.1 %, MMP selectivity = 100 %) in the oil bath at the same temperature. Such higher conversion efficiency and selectivity under sunlight should result from the synergistic integration of hot electrons and photothermal heating, both of which are derived from localized surface plasmon resonance (LSPR) in WO3-x. Importantly, Pd/WO3-x catalyst demonstrates good stability and high selectivity to MMP even after 5 cycles. This work may offer a novel viewpoint on the advancement of photothermal catalysts and the realization of photothermal catalytic biomass conversion under mild conditions.

One Stone, Three Birds: Design and Synthesis of "All-in-One" Nanoscale Mn-Porphyrin Coordination Polymers for Magnetic Resonance Imaging-Guided Synergistic Photodynamic-Sonodynamic Therapy.

Multifunctional nanomaterials with potential applications in both bioimaging and photodynamic-sonodynamic therapy have great advantages in cancer theranostic, but the design and preparation of "all-in-one" type of multifunctional nanomaterials with single component remains challenging. Herein the "all-in-one" type of Mn-PpIX (Protoporphyrin IX) coordination polymers (MnPPs) was reported as efficient nano-photo/sonosensitizers. The MnPPs had an average size of âˆ¼ 110 nm. Upon light/US (ultrasound) irradiation for 5 min, 61.8 % (light) and 32.4 % (US) of DPBF (1.3-diphenyl isobenzofuran) was found to be oxidized by MnPPs, which showed effective ROS (reactive oxygen species) generation for photodynamic/sonodynamic therapy (PDT/SDT). In addition, MnPPs revealed excellent biosafety and could be engulfed by cells to produce intracellular ROS under light/US excitation for efficient killing tumor cells. When MnPPs was injected into mice, the tumor could be monitored via MRI (magnetic resonance imaging). In addition, tumor growth could be significantly inhibited by the synergistic PDT-SDT. Therefore, the present study not only represents MnPPs as an "all-in-one" type of multifunctional nanomaterials for MRI-guided PDT-SDT therapy, but also provides some insights for designing other PpIX-related molecules with the similar structure for bioapplication.

Healthcare-seeking behavior for respiratory illnesses in Kenya: implications for burden of disease estimation.

BACKGROUND: Understanding healthcare-seeking patterns for respiratory illness can help improve estimation of disease burden and target public health interventions to control acute respiratory disease in Kenya. METHODS: We conducted a cross-sectional survey to determine healthcare utilization patterns for acute respiratory illness (ARI) and severe pneumonia in four diverse counties representing urban, peri-urban, rural mixed farmers, and rural pastoralist communities in Kenya using a two-stage (sub-locations then households) cluster sampling procedure. Healthcare seeking behavior for ARI episodes in the last 14 days, and severe pneumonia in the last 12 months was evaluated. Severe pneumonia was defined as reported cough and difficulty breathing for > 2 days and report of hospitalization or recommendation for hospitalization, or a danger sign (unable to breastfeed/drink, vomiting everything, convulsions, unconscious) for children < 5 years, or report of inability to perform routine chores. RESULTS: From August through September 2018, we interviewed 28,072 individuals from 5,407 households. Of those surveyed, 9.2% (95% Confidence Interval [CI] 7.9-10.7) reported an episode of ARI, and 4.2% (95% CI 3.8-4.6) reported an episode of severe pneumonia. Of the reported ARI cases, 40.0% (95% CI 36.8-43.3) sought care at a health facility. Of the74.2% (95% CI 70.2-77.9) who reported severe pneumonia and visited a medical health facility, 28.9% (95% CI 25.6-32.6) were hospitalized and 7.0% (95% CI 5.4-9.1) were referred by a clinician to the hospital but not hospitalized. 21% (95% CI 18.2-23.6) of self-reported severe pneumonias were hospitalized. Children aged < 5 years and persons in households with a higher socio-economic status were more likely to seek care for respiratory illness at a health facility. CONCLUSION: Our findings suggest that hospital-based surveillance captures less than one quarter of severe pneumonia in the community. Multipliers from community household surveys can account for underutilization of healthcare resources and under-ascertainment of severe pneumonia at hospitals.

Multifunctional hemoporfin-Cu9S8-MnO2 for magnetic resonance imaging-guided catalytically-assisted photothermal-sonodynamic therapies.

Integrated theranostic nanoplatforms with multi-model imaging and therapeutic functions are attracting great attention in cancer treatments, while the design and preparation of such nanoplatforms remain an open challenge. Herein, we report hemoporfin@Cu9S8@MnO2 nanoparticles (H@Cu9S8@MnO2 NPs) as multifunctional nanoplatforms for magnetic resonance imaging-guided catalytically-assisted photothermal-sonodynamic therapies of tumors. Cu9S8 hollow spherical nanoparticles were firstly prepared by in-situ vulcanization of Cu2O, and the growth of MnO2 shell was realized by the reduction of manganese permanganate, where the hollow structure of Cu9S8 could be used to load hemoporfin sonosensitizer. Cu9S8@MnO2 nanoparticles with diameters of âˆ¼ 130 nm exhibit increased photoabsorption in near-infrared (NIR) region (680-1100 nm) due to the plasmonic effect of Cu9S8, and the photothermal conversion efficiency is determined to be 32.5% under 1064 nm laser irradiation. Furthermore, MnO2 shells can mimic catalase to trigger the decomposition of endogenous H2O2 into O2 with a significant O2 elevation (14.7 mg L-1) within 8 min and then promote the production of 1O2 via sonodynamic effect of hemoporfin. Meanwhile, MnO2 shells provide the T1-weight magnetic resonance (MR) imaging function. When H@Cu9S8@MnO2 NPs solution is administered to the mice, the tumor growth can be effectively inhibited due to catalytically-assisted synergetic photothermal-sonodynamic therapies which have superior therapeutic effect compared to mono-model therapy alone. Thus, H@Cu9S8@MnO2 NPs present a promising strategy for the development of integrated theranostic nanoplatforms with multi-model imaging and therapy functions.

Reusable Cu2-xS-modified masks with infrared lamp-driven antibacterial and antiviral activity for real-time personal protection.

Disposable surgical masks are widely used by the general public since the onset of the coronavirus outbreak in 2019. However, current surgical masks cannot self-sterilize for reuse or recycling for other purposes, resulting in high economic and environmental costs. To solve these issue, herein we report a novel low-cost surgical mask decorated with copper sulfide (Cu2-xS) nanocrystals for photothermal sterilization in a short time (6 min). With the spun-bonded nonwoven fabrics (SNF) layer from surgical masks as the substrate, Cu2-xS nanocrystals are in-situ grown on their surface with the help of a commercial textile adhesion promoter. The SNF-Cu2-xS layer possesses good hydrophobicity and strong near infrared absorption. Under the irradiation with an infrared baking lamp (IR lamp, 50 mW cm-2), the surface temperature of SNF-Cu2-xS layer on masks can quickly increase to over 78 °C, resulting from the high photothermal effects of Cu2-xS nanocrystals. As a result, the polluted masks exhibit an outstanding antibacterial rate of 99.9999% and 85.4% for the Escherichia coli (E.coli) and Staphylococcus aureus (S. aureus) as well as the inactivation of human coronavirus OC43 (3.18-log10 decay) and influenza A virus A/PR/8/34 (H1N1) (3.93-log10 decay) after 6 min irradiation, and achieve rapid sterilization for reuse and recycling. Therefore, such Cu2-xS-modified masks with IR lamp-driven antibacterial and antiviral activity have great potential for real-time personal protection.

Synthesis of MnO2-Ag Nanojunctions with Plasmon-Enhanced Photocatalytic and Photothermal Effects for Constructing Rewritable Mono-/Multi-Color Fabrics.

Semiconductor-mediated photoreversible color switching systems (PCSSs) have great potential to replace traditional photochromic materials, and the key is to obtain semiconductors with unique photocatalytic and photothermal features. Herein, we have developed MnO2-Ag nanojunctions with plasmon-enhanced photocatalytic and photothermal effects for PCSSs. MnO2-Ag nanojunctions are solvothermally synthesized with Mn(CH3COO)3, KMnO4, and AgNO3 in diethylene glycol as precursors, and they are composed of MnO2 nanoparticles (∼30 nm) that are decorated by Ag nanodots (∼6 nm). The presence of Ag confers an enhanced visible photoabsorption with a narrow band gap for MnO2 (Eg = 1.82 eV) and a weak/broad photoabsorption tail (∼875 nm) compared to that of pure MnO2 (2.45 eV, ∼625 nm). By coupling MnO2-Ag nanojunctions with various redox dyes, some PCSS inks can be obtained, and especially, the inks containing hydroxyethyl cellulose could be used to prepare rewritable fabrics. When inks and fabrics are irradiated by 475 nm light, rapid discoloration can occur, resulting from the photocatalytic reduction of the dye. Contrarily, the irradiation of 808 nm light promotes the rapid recoloration since Ag nanodots with plasmonic effects in the nanojunctions can absorb light to generate heat, which facilitates the oxidization of leuco dyes in air. Consequently, remote printing of figures was attained on the rewritable fabrics via 475 nm light illumination, and then, the erasure was performed by 808 nm light illumination in an O2 atmosphere, with high reversibility and cycling stability. Therefore, MnO2-Ag nanojunctions have tremendous promise for rewritable media, and the introduction of metal-semiconductor junctions as a nanophotocatalyst offers new insights for PCSSs.

Transforming a Sword into a Knife: Persistent Phototoxicity Inhibition and Alternative Therapeutical Activation of Highly-Photosensitive Phytochlorin.

The phototoxicity of photosensitizers (PSs) is a double-edged sword with one edge beneficial for destroying tumors while the other is detrimental to normal tissues, and the conventional "OFF-ON" strategy provides temporary inhibition so that phototoxicity would come sooner or later due to the inevitable retention and transformation of PSs in vivo. We herein put forward a strategy to convert "double-edged sword" PSs into "single-edged knife" ones with simultaneously persistent phototoxicity inhibition and alternative multiple therapeutical activation. The Chlorin e6 (Ce6) as the PS model directly assembles with Cu2+ ions into nanoscale frameworks (nFs) whose Cu2+-coordination includes both carboxyl groups and a porphyrin ring of Ce6 instead of Fe3+/Mn2+-coordination with only carboxyl groups. Compared to the high phototoxicity of Ce6, the nFs exhibit efficient energy transfer due to the dual-coordination of paramagnetic Cu2+ ions and the aggregation, achieving the persistent and high phototoxicity inhibition rate of >92%. Alternatively, the nFs not only activate a high photoacoustic contrast and near-infrared (NIR)-driven photothermal efficacy (3.5-fold that of free Ce6) due to the aggregation-enhanced nonradiative transition but also initiate tumor microenvironment modulation, structure disassembly, and chemodynamic effect by Cu2+ ions. Given these merits, the nFs achieve long-term biosecurity, no retina injury under sunlight, and a higher therapeutical output than the photodynamic effect of Ce6. This work presents a possibility of converting numerous highly phototoxic porphyrins into safe and efficient ones.

GSH-Sensitive Nanoscale Mn3+-Sealed Coordination Particles as Activatable Drug Delivery Systems for Synergistic Photodynamic-Chemo Therapy.

Activatable nanoscale drug delivery systems (NDDSs) are promising in maximizing cancer specificity and anticancer efficacy, and a multifunctional metal-organic nanomaterial is one of the new star NDDSs which requires further exploration. Herein, a novel DOX@MnCPs/PEG NDDSs were constructed by first synthesizing Mn3+-sealed coordination particles (MnCPs), modified with a targeted PEGylated polymer, and then loading anticancer drug doxorubicin (DOX). MnCPs were prepared from the assembly of Mn3+ ions and hematoporphyrin monomethyl ether (HMME) molecules. Furthermore, MnCPs had an average size of ∼100 nm and a large surface area (∼52.6 m2 g-1) and porosity (∼3.6 nm). After the loading of DOX, DOX@MnCPs/PEG exhibited a high DOX-loading efficacy of 27.2%, and they reacted with glutathione (GSH) to confer structural collapse, leading to the production of Mn2+ ions for enhanced magnetic resonance imaging (MRI), free HMME for augmented photodynamic effect, and free DOX for chemotherapy. As a consequence, these DOX@MnCPs/PEG NDDSs after intravenous injection showed efficient tumor homing and then exerted an obvious suppression for tumor growth rate by synergistic photodynamic-chemo therapy in vivo. Importantly, most of the DOX@MnCPs/PEG NDDSs could be gradually cleared through the renal pathway, and the remaining part could slowly be metabolized via the feces, enabling high biosafety. Therefore, this work provides a type of GSH-sensitive NDDS with biosafety, caner specificity, and multifunctionality for high synergistic treatment efficacy.

Impact of Kenya's Frontline Epidemiology Training Program on Outbreak Detection and Surveillance Reporting: A Geographical Assessment, 2014-2017.

Rapid detection and response to infectious disease outbreaks requires a robust surveillance system with a sufficient number of trained public health workforce personnel. The Frontline Field Epidemiology Training Program (Frontline) is a focused 3-month program targeting local ministries of health to strengthen local disease surveillance and reporting capacities. Limited literature exists on the impact of Frontline graduates on disease surveillance completeness and timeliness reporting. Using routinely collected Ministry of Health data, we mapped the distribution of graduates between 2014 and 2017 across 47 Kenyan counties. Completeness was defined as the proportion of complete reports received from health facilities in a county compared with the total number of health facilities in that county. Timeliness was defined as the proportion of health facilities submitting surveillance reports on time to the county. Using a panel analysis and controlling for county-fixed effects, we evaluated the relationship between the number of Frontline graduates and priority disease reporting of measles. We found that Frontline training was correlated with improved completeness and timeliness of weekly reporting for priority diseases. The number of Frontline graduates increased by 700%, from 57 graduates in 2014 to 456 graduates in 2017. The annual average rates of reporting completeness increased from 0.8% in 2014 to 55.1% in 2017. The annual average timeliness reporting rates increased from 0.1% in 2014 to 40.5% in 2017. These findings demonstrate how global health security implementation progress in workforce development may influence surveillance and disease reporting.

Cell membrane camouflaged bismuth nanoparticles for targeted photothermal therapy of homotypic tumors.

Bi nanoparticles (NPs) have been demonstrated as effective all-in-one type theranostic agent for imaging-guided photothermal therapy, but their applications have been limited by relatively low biocompatibility and target accumulation capacity. To address this issue, we report the camouflage of Bi NPs (size: ~42 ± 2 nm) by using the mouse colon cancer CT26 cells membrane (CT26 CCM). The camouflaging process confers the efficient coating of CCM shell layer with thickness of ~8 ± 2 nm on Bi NPs cores, which can be confirmed by TEM image, zeta potential and protein gel electrophoresis tests. Simultaneously, CCM shell has no side effects on the photoabsorption/photothermal effect. Importantly, Bi@CCM NPs retain significant features of CCM, including good biocompatibility and homologous targeting ability. When Bi@CCM dispersion was intravenously (i.v.) injected into mice, they exhibited higher blood circulation half-life (11.5 h, ~2.9 times) and accumulation amount (4.7 ± 0.56% ID/g, ~2.3 times) in homotypic CT26 tumor compared to those (4.0 h in blood and 2.03 ± 0.60% ID/g in tumor) from uncoated Bi NPs. After 808 nm laser irradiation, CT26 cancer cells could be effectively ablated after the photothermal therapy of high-accumulated Bi@CCM NPs, and then the tumor tends to be eradicated after 12 days. Thus, Bi NPs camouflaged with CT26 CCM have great potential for the targeted photothermal therapy of homotypic tumors.

Use of technology for public health surveillance reporting: opportunities, challenges and lessons learnt from Kenya.

BACKGROUND: Effective public health surveillance systems are crucial for early detection and response to outbreaks. In 2016, Kenya transitioned its surveillance system from a standalone web-based surveillance system to the more sustainable and integrated District Health Information System 2 (DHIS2). As part of Global Health Security Agenda (GHSA) initiatives in Kenya, training on use of the new system was conducted among surveillance officers. We evaluated the surveillance indicators during the transition period in order to assess the impact of this training on surveillance metrics and identify challenges affecting reporting rates. METHODS: From February to May 2017, we analysed surveillance data for 13 intervention and 13 comparison counties. An intervention county was defined as one that had received refresher training on DHIS2 while a comparison county was one that had not received training. We evaluated the impact of the training by analysing completeness and timeliness of reporting 15 weeks before and 12 weeks after the training. A chi-square test of independence was used to compare the reporting rates between the two groups. A structured questionnaire was administered to the training participants to assess the challenges affecting surveillance reporting. RESULTS: The average completeness of reporting for the intervention counties increased from 45 to 62%, i.e. by 17 percentage points (95% CI 16.14-17.86) compared to an increase from 49 to 52% for the comparison group, i.e. by 3 percentage points (95% CI 2.23-3.77). The timeliness of reporting increased from 30 to 51%, i.e. by 21 percentage points (95% CI 20.16-21.84) for the intervention group, compared to an increase from 31 to 38% for the comparison group, i.e.by 7 percentage points (95% CI 6.27-7.73). Major challenges for the low reporting rates included lack of budget support from government, lack of airtime for reporting, health workers strike, health facilities not sending surveillance data, use of wrong denominator to calculate reporting rates and surveillance officers having other competing tasks. CONCLUSIONS: Training plays an important role in improving public health surveillance reporting. However, to improve surveillance reporting rates to the desired national targets, other challenges affecting reporting must be identified and addressed accordingly.

Blue/red light-triggered reversible color switching based on CeO2-x nanodots for constructing rewritable smart fabrics.

Photoreversible color switching systems (PCSSs) have attracted increasing attention in various applications, but in most PCSSs the discoloration process usually relies on harmful UV light as a stimulus and the recoloration requires high temperature. To solve these problems, we have designed and prepared CeO2-x nanodots as novel photocatalytic components in PCSSs that respond to two kinds of visible light. CeO2-x nanodots are prepared by a solvothermal reaction with l-ascorbic acid as the reducing agent. CeO2-x nanodots with a size of ∼2 nm have a high concentration of oxygen vacancies, which confers a broadened photoabsorption with an edge at 500 nm, as well as a weak photoabsorption tail in the visible region (500-800 nm). To realize the color switching, both the CeO2-x/Dye/H2O solution and CeO2-x/dye/hydroxyethyl cellulose (HEC)-coated fabrics have been prepared. Under blue (450 nm) light irradiation, both the solution and fabric show a rapid discoloration in 30 s and 150 s, respectively, due to the efficient photocatalytic reduction of the redox dye by CeO2-x. Conversely, red (630 nm) light irradiation with air confers a rapid recoloration in 35 s for the solution and 200 s for the fabric, resulting from CeO2-x-mediated self-catalyzed oxidation. In particular, the required images and letters can be remotely printed on CeO2-x/Dye/HEC-coated T-shirts with a 450 nm laser pen, and then erased with 630 nm light, with high reversibility and stability. Therefore, the present CeO2-x/Dye/HEC PCSSs have great potential to construct rewritable smart fabrics for various applications.

Construction of titanium dioxide/cadmium sulfide heterojunction on carbon fibers as weavable photocatalyst for eliminating various contaminants.

Semiconductor heterojunction powders have exhibited the enhanced photocatalytic activities, but their practical applications have been limited due to their poor recycling performance from flowing wastewater. To solve these problems, with carbon fibers (CFs) as the fixing substrate, we constructed TiO2/CdS heterojunction as a model on CF surface by utilizing a hydrothermal-chemical bath deposition method. CFs/TiO2/CdS bundles display a wide photoabsorption with two photoabsorption edges (~410 and 520 nm). Furthermore, CFs/TiO2/CdS bundles can be weaved into macroscopical cloth (such as weight: 0.1 g, area: 4 × 4 cm2) which have considerable photocurrent density of 5.75 × 10-6 A/cm2. Under visible light irradiation (λ > 400 nm), macroscopic CFs/TiO2/CdS cloth can degrade 95.44% methylene blue (MB), 64.95% acid orange 7 (AO7), 91.37% tetracycline hydrochloride (TC) and remove 90.70% hexavalent chromium (Cr(VI)) after 120 min, higher than those by CFs/CdS (43.42% MB, 37.42% AO7, 31.76% TC and 30.45% Cr(VI)) or CFs/TiO2 (12.84% MB, 10.48% AO7, 11.85% TC and 15.58% Cr(VI)). Thus, CFs/TiO2/CdS can act as a weavable and efficient photocatalyst for eliminating various pollutants from wastewater.

Flexible and Washable CNT-Embedded PAN Nonwoven Fabrics for Solar-Enabled Evaporation and Desalination of Seawater.

Nanostructured photothermal membranes hold great potential for solar-driven seawater desalination; however, their pragmatic applications are often limited by substantial salt accumulation. To solve this issue, we have designed and prepared flexible and washable carbon-nanotube-embedded polyacrylonitrile nonwoven fabrics by a simple electrospinning route. The wet fabric exhibits a strong photoabsorption in a wide spectral range (350-2500 nm), and it has a photoabsorption efficiency of 90.8%. When coated onto a polystyrene foam, the fabric shows a high seawater evaporation rate of 1.44 kg m-2 h-1 under simulated sunlight irradiation (1.0 kW m-2). With a high concentration of simulated seawater as the model, the accumulation of solid salts can be clearly observed on the surface of the fabric, resulting in a severe decay of the evaporation rate. These salts can be effortlessly washed away from the fabric through a plain handwashing process. The washing process has a negligible influence on the morphology, photoabsorption, and evaporation performance of the fabric, demonstrating good durability. More importantly, a larger fabric can easily be fabricated, and the combination of washable fabrics with various parallel PS foams can facilitate the construction of large-scale outdoor evaporation devices, conferring the great potential for efficient desalination of seawater under natural sunlight.

UV/NIR-Light-Triggered Rapid and Reversible Color Switching for Rewritable Smart Fabrics.

Remote, rapid, and ink-free printing/erasure on fabrics has great potential to revolutionize specialized clothing in numerous applications including fashion/aesthetic and security fields, but the construction of such smart fabrics has not been realized due to underlying obstacles in obtaining suitable photoreversible color-switching systems (PCSS). To address this problem, we have prepared TiO2- x nanorods as photocatalytic and photothermal component. With redox dyes as reversible color indicators and hydroxyethyl cellulose (HEC) as polymer matrix, TiO2- x/dye/HEC-based PCSS is coated on poly(dimethylsiloxane)-treated cotton fabric. Under 365 nm light irradiation, discoloration occurs in 180 s, resulting from the efficient photocatalytic reduction of the dye. On the contrary, when the colorless fabric is irradiated by 808 nm light, recoloration occurs in a very short time (∼100 s), far lower than the traditional heating mode (30-8 min at 90-150 °C). This rapid recoloration should be attributed to the localized high temperature (164.3-184.5 °C) induced by photothermal effect of TiO2- x. Particularly, when TiO2- x/dye/HEC-based PCSS is extended to coat commercial clothes (such as T-shirts), red/green/blue figures/letters can be rapidly and remotely printed by UV-light pen and then erased by near-infrared light, with high cycle stability. Therefore, such rewritable smart fabric represents an attractive alternative to regular clothes in meeting the increasing aesthetic or camouflage needs.

Construction of Ag/AgCl-CN heterojunctions with enhanced photocatalytic activities for degrading contaminants in wastewater.

The non-metallic organic polymer carbon nitride has attracted widespread attentions, but its photocatalytic performance is unsatisfactory due to high recombination of photoinduced carriers. To solve this issue, we report Ag/AgCl-decorated carbon nitride (CN) nanorod heterojunctions as efficient and stable photocatalyst. CN nanorods (diameter: ∼25 nm; lengths: 1-1.5 µm) were prepared by a simple solvothermal route, and then in-situ growth of Ag/AgCl nanoparticles (diameter: 20-40 nm) on CN surface was realized by a facile co-precipitation method. Ag/AgCl-decorated CN heterojunctions with diverse Ag/CN precursor molar-ratios (0.3, 0.5, 0.7) exhibit a wide absorption spectrum from UV to visible-light region (∼750 nm). After the illumination of visible-light for 120 min, 0.5-Ag/AgCl-CN nanorods can degrade 98.5% rhodamine B (RhB), 75.4% tetracycline (TC) and 39.5% Cr(VI), obviously better than those of CN nanorods (62.6% RhB, 35.6% TC, 19.7% Cr(VI)), Ag/AgCl nanoparticles (66.5% RhB, 18.5% TC, 24.6% Cr(VI)) and Ag-CN (72.6% RhB, 39.4% TC, 28.7% Cr(VI)). This obvious improvement should result from efficient separation of photogenerated carriers. Therefore, Ag/AgCl-CN can act as an efficient and stable visible-light-driven photocatalyst.

Structure based optical properties and catalytic activities of hydrothermally prepared CuS nanostructures.

The nano-sized copper sulfides (CuS) with different morphologies were prepared by hydrothermal method without any surfactant or template. The morphology and structure of CuS were characterized by powder x-ray diffraction (XRD), Fourier transform infrared spectroscopy, x-ray photoelectron spectra (XPS), field emission scanning electron microscopy (FESEM), high-resolution transmission electron microscopy (HRTEM), Brunauer-Emmett-Teller (BET) and ultraviolet-visible (UV-vis) absorption spectroscopy. FESEM results show that four morphologies of CuS (flower-like nanospheres, cross-linked nanodisks, cross-linked nanoplates and nanosheets) were prepared simply by changing the hydrothermal solvent. According to the XPS, XRD and HRTEM results the synthesized nano-sized structures are highly crystallized pure hexagonal covellite CuS. UV-vis spectra results show intense absorption peaks in the visible region, confirming that the resultant CuS has potential application in the field of solar cells. The catalytic activities of resultant CuS on model pollutant methylene blue (MB) in the dark were also investigated in detail. The small and flat crystallites show rapid degradation rate on MB, which is attributed to the numerous active sites on their large specific surface area. The as-synthesized CuS nanosheets took the shortest time (only 15 min) to degrade MB completely compared with the other nanostructural CuS in this work as well as previously reported ones. Total organic carbon removal of the samples approved mineralization of the MB pollutant. Thus, CuS is an excellent catalyst for degrading organic pollutants, which does not require light energy for its catalytic activities.

Cholera Outbreak in Dadaab Refugee Camp, Kenya - November 2015-June 2016.

Dadaab Refugee camp in Garissa County, Kenya, hosts nearly 340,000 refugees in five subcamps (Dagahaley, Hagadera, Ifo, Ifo2, and Kambioos) (1). On November 18 and 19, 2015, during an ongoing national cholera outbreak (2), two camp residents were evaluated for acute watery diarrhea (three or more stools in ≤24 hours); Vibrio cholerae serogroup O1 serotype Ogawa was isolated from stool specimens collected from both patients. Within 1 week of the report of index cases, an additional 45 cases of acute watery diarrhea were reported. The United Nations High Commissioner for Refugees and their health-sector partners coordinated the cholera response, community outreach and water, sanitation, and hygiene (WASH) activities; Médecins Sans Frontiéres and the International Rescue Committee were involved in management of cholera treatment centers; CDC performed laboratory confirmation of cases and undertook GIS mapping and postoutbreak response assessment; and the Garissa County Government and the Kenya Ministry of Health conducted a case-control study. To prevent future cholera outbreaks, improvements to WASH and enhanced disease surveillance systems in Dadaab camp and the surrounding area are needed.

Synthesis of Au nanoparticle-decorated carbon nitride nanorods with plasmon-enhanced photoabsorption and photocatalytic activity for removing various pollutants from water.

Herein we have developed Au nanoparticle-decorated carbon nitride (Au-CN) nanorods as novel and efficient photocatalysts. Au-CN with different Au/CN precursor molar ratios (0.5%, 1% and 2%) have been prepared by a solvothermal-hydrothermal two-step method, where CN nanorods have diameters of 20-30nm and length of 0.5-1µm while Au nanoparticle have diameter of ∼13nm. Au-CN nanorods exhibit a broad photoabsorption from ultraviolet to near-infrared with edge at ∼790nm, revealing an obvious red-shift compared with g-C3N4 bulk (∼460nm), CN nanorods (∼715nm). Under visible-light irradiation, 1%Au-CN nanorods exhibit the highest photocatalytic activity, and they can degrade 98.2% rhodamine B (RhB), 77.2% 4-chlorophenol (4-CP), 83.9% tetracycline (TC) and reduce 43.6% hexavalent chromium (Cr(VI)) in 120min, higher than those by pure CN nanorods (70.3% RhB, 36.6% 4-CP, 54.6% TC, 23.1% Cr(VI)) and g-C3N4 bulk (31.5% RhB, 17.2% 4-CP, 36.9% TC, 11.8% Cr(VI)). Compared with CN nanorods, the obvious improvement of photocatalytic activity of 1%Au-CN nanorods should be attributed to the plasmon-enhanced photoabsorption and efficient separation of hole-electron pairs due to the introduction of Au nanoparticles.

PEGylated (NH4)xWO3 nanorods as efficient and stable multifunctional nanoagents for simultaneous CT imaging and photothermal therapy of tumor.

The simultaneous imaging and photothermal therapy of tumors have attracted much attention, and a prerequisite is to obtain multifunctional nanomaterials. Ideally, one kind of nanoparticles with single component can be used as both imaging agent and photothermal agent. Herein, we have developed the PEGylated (NH4)xWO3 (denoted as (NH4)xWO3-PEG) nanorods as multifunctional nanoparticles with single semiconductor component. (NH4)xWO3-PEG nanorods with about 30nm diameter and length of several hundred nanometers have been obtained through a solvothermal synthesis-PEGylation two-step route. Under the irradiation of 980-nm laser with intensity of 0.72Wcm-2, aqueous dispersion of (NH4)xWO3-PEG nanorods (0.67-5.44mmol/L) displays high elevation (17.6-34.5°C) of temperature in 400s, accompanied by an excellent long-term photothermal stability. Furthermore, (NH4)xWO3-PEG nanorods exhibit as high as 6 times X-ray attenuation ability compared to that of the clinically used iodine-based X-ray computed tomography (CT) contrast agent (Iopromide). More importantly, after PBS solution of (NH4)xWO3-PEG nanorods is injected into the tumor of mice, the tumor can be effectively detected by CT imaging. Moreover, cancer cells in vivo can be further destroyed by the photothermal effects of (NH4)xWO3-PEG nanorods, under the irradiation of 980-nm laser with the safe intensity of 0.72Wcm-2 for 10min. Therefore, (NH4)xWO3-PEG nanorods can be used as a new kind of stable and efficient multifunctional nanoagent with single component for simultaneous CT imaging and photothermal therapy of tumor.