ABSTRACT
Parameters of systemic immunity, activity of cation proteins of neutrophilic granulocytes and individual blood serum proteins were studied in two groups of patients: with newly diagnosed (83) and chronic destructive pulmonary tuberculosis (105). Four levels of T-lymphocytes were established per their absolute content in 1 ul of the peripheral blood, which had different interconnection with cell response intensity to mitogenic PHA stimulation and the values of the lysosomal cation++ test in both groups of patients. Indications for the prescription of immune active preparations based upon the T-cell level and, when necessary, supplemented by information related to the values of BTR with PHA and BTR with PPD were developed for both groups of patients independently of hereditary consolidated serum proteins.
Subject(s)
Tuberculosis, Pulmonary/immunology , Adult , Female , Haptoglobins/analysis , Humans , Leukocyte Count , Lymphocyte Activation , Male , Middle Aged , Neutrophils/immunology , Phytohemagglutinins , Rosette Formation , T-Lymphocytes/immunology , T-Lymphocytes/pathology , Tuberculosis, Pulmonary/bloodABSTRACT
Functional activity of T-lymphocyte suppressors (spontaneous and Con-A induced) has been studied in 17 patients with destructive pulmonary tuberculosis. Patients with ++fibrous-cavernous pulmonary tuberculosis were found to have characteristic disturbances of the regulatory lymphocyte function and a high index of theophylline-resistant E-RFC/theophylline-sensitive E-RFC in the presence of a general reduction of the immunity T-system indices. A higher balance of the regulatory lymphocytes was seen in patients with infiltrative tuberculosis in various disorders of the immunologic parameters.
Subject(s)
Lymphopenia/etiology , T-Lymphocytes/immunology , Tuberculosis, Pulmonary/immunology , Adult , Concanavalin A/pharmacology , Female , Humans , In Vitro Techniques , Leukocyte Count , Lymphocyte Activation/drug effects , Lymphocyte Activation/immunology , Male , Middle Aged , Rosette Formation , T-Lymphocytes/pathology , Tuberculosis, Pulmonary/complicationsABSTRACT
Systemic immunity and nonspecific resistance were studied in 127 new cases of pulmonary tuberculosis with the lysosomal cationic test (LCT). 4 types of immunograms based on the absolute count of T-lymphocytes in peripheral blood were revealed. It was shown that the immunogram types corresponded to the disease clinicoroentgenological picture which made it possible to perform individual pathogenetic therapy with thymus immunoactive preparations. A normalizing effect of T-activin on the lowered indices of the LCT was observed.
