[Increase of pathogenicity of Staphylococcus aureus strains caused by lysogenic conversion by phages of serologic group F]. / Wzrost patogennosci szczepów gronkowca zlocistego spowodowany konwersja lizogenna fagami grupy serologicznej F.

The substantial influence of presence of the double converting prophages of the serological group F on the decrease of intensity of human leukocytes stimulation with lysogenic cells of S. aureus was determined. The end values of chemiluminescence in the six experimental systems containing lysogenic bacteria were only from 15.4 to 37.2% of the value in the control sample. The end values of the intercellular killing of the two lysogenic variants were twofold lower than in controls. Third of the investigated variants was completely resistant to intracellular killing in the applied system, and revealed 27% of growth stimulation.

[Bacteriophage conversion as a factor modifying the intensity of phagocytosis of Staphylococcus aureus by human leukocytes]. / Konwersja fagowa jako czynnik modyfikujacy intensywnosc fagocytozy Staphylococcus aureus przez leukocyty ludzkie.

Staphylococcus aureus NCTC 8325-4 and its eight variants lysogenized with phages responsible for the synthesis of staphylococcal staphylokinase were used for the study. Influence of phage conversion of S. aureus on its interaction with human leucocytes and influence of prophage on strain susceptibility to intracellular killing by human granulocytes without opsonins were evaluated. It was found that lysogenization of the strain with the bacteriophages decreased in each case reactivity of human leucocytes for staphylococcal strain what was expressed by lower bioluminescence values and by lower percentage of intracellular killing of bacterial cells carrying prophage.