ABSTRACT
INTRODUCTION: Epilepsy affects millions of people and its geographical patterns are usually linked to etiological aspects. Our objective was to describe main etiologies of epilepsy in Mexico. PATIENTS AND METHODS: We selected patients from the Multicenter Epilepsy Registry carried out from 2021 to 2022 in 89 Mexican hospitals in 31 states, a sample predominantly of pediatric age. Only patients with electroencephalography and neuroimaging studies were included. RESULTS: We analyzed 6,653 patients with documented etiologies. Etiology frequency with confidence interval (95% CI) was: structural 46.1% (44.9-47.3), genetic 12.9% (12.1-13.7), infectious 2.9%. (2.5-3.3), metabolic 1.4% (1.1-1.7), immune 0.9% (0.8-1.3) and unknown 40.9% (39.8-42.2). The two main structural etiologies were malformations of cortical development and hypoxic-ischemic encephalopathy. Neurocysticercosis represented a minority with only 1%. Structural and genetic etiologies were associated with focal and generalized onset seizures respectively. Status epilepticus was identified, mostly with motor component, associated with immune and infectious etiologies. Comorbidities were found in 61.6%, mainly neurological development disorders. Drug-resistant epilepsy was more common in patients with immune, infectious and structural etiologies. CONCLUSIONS: The main etiology of epilepsy was structural. The frequency of genetic etiology was relatively lower than in other series, possibly due to the limited availability of genetic tests. Despite technological advances, a large fraction of epilepsies still has unknown origin.
TITLE: Etiología de la epilepsia en México: resultados del registro multicéntrico nacional.Introducción. La epilepsia afecta a millones de personas y sus patrones geográficos suelen estar vinculados a aspectos etiológicos. Nuestro objetivo fue describir las principales etiologías de epilepsia en México. Pacientes y métodos. Seleccionamos a pacientes del Registro Multicéntrico de Epilepsia realizado de 2021 a 2022 en 89 hospitales mexicanos de 31 estados, una muestra con predominio en edad pediátrica. Se incluyó a pacientes con estudios de electroencefalografía y neuroimagen. Resultados. Analizamos a 6.653 pacientes con etiologías documentadas. Las frecuencias de etiologías con intervalo de confianza al 95% fueron: estructural, 46,1% (44,9-47,3); genética, 12,9% (12,1-13,7); infecciosa, 2,9% (2,5-3,3); metabólica, 1,4% (1,1-1,7); inmunitaria, 0,9% (0,8-1,3); y desconocida, 40,9% (39,8-42,2). Las dos principales etiologías estructurales fueron las malformaciones del desarrollo cortical y la encefalopatía hipóxico-isquémica. La neurocisticercosis representó una minoría, con sólo el 1%. Las etiologías estructurales y genéticas se relacionaron con crisis de inicio focal y generalizado, respectivamente. Se identificó estado epiléptico, en su mayoría con componente motor, asociado a etiologías inmunitarias e infecciosas. Se encontraron comorbilidades en el 61,6%, principalmente trastornos del desarrollo neurológico. La epilepsia farmacorresistente fue más frecuente en pacientes con etiologías inmunitaria, infecciosa y estructural. Conclusiones. La principal etiología de la epilepsia fue estructural. La frecuencia de etiología genética fue menor que en otras series por la limitada disponibilidad de pruebas genéticas. A pesar de los avances tecnológicos, una gran parte de las epilepsias aún tiene un origen desconocido.
Subject(s)
Epilepsy , Registries , Humans , Mexico/epidemiology , Epilepsy/etiology , Epilepsy/epidemiology , Male , Female , Child , Adolescent , Child, Preschool , Adult , Infant , Young Adult , Middle AgedABSTRACT
Breast and gynecological cancers are major health concerns due to their increasing incidence rates, and in some cases, their low survival probability. In recent years, multiple compounds of natural origin have been analyzed as alternative treatments for this disease. For instance, Acetogenins are plant secondary metabolites from the Annonaceae family, and its potential anticancer activity has been reported against a wide range of cancer cells both in vitro and in vivo. Several studies have demonstrated promising results of Acetogenins' antitumor capacity, given their selective activity of cellular inhibition at low concentrations. This review outlines the origin, structure, and antineoplastic activities in vitro and in vivo of Acetogenins from Annonaceae against breast cancer and gynecological cancers reported to date. Here, we also provide a systematic summary of the activity and possible mechanisms of action of Acetogenins against these types of cancer and provide references for developing future therapies based on Acetogenins and nanotechnologies.
Subject(s)
Acetogenins , Annonaceae , Antineoplastic Agents, Phytogenic , Breast Neoplasms , Genital Neoplasms, Female , Acetogenins/pharmacology , Acetogenins/chemistry , Acetogenins/isolation & purification , Humans , Breast Neoplasms/drug therapy , Female , Antineoplastic Agents, Phytogenic/pharmacology , Antineoplastic Agents, Phytogenic/isolation & purification , Antineoplastic Agents, Phytogenic/therapeutic use , Genital Neoplasms, Female/drug therapy , Annonaceae/chemistry , Molecular Structure , Phytochemicals/pharmacology , Phytochemicals/isolation & purification , AnimalsABSTRACT
BACKGROUND: Fluoride is an inorganic element, which can be found in high concentrations in groundwater. Its consumption and exposure have consequences on human health. The objective of this study was to evaluate fluoride exposure and develop a health risk assessment in children from an urban area with hydrofluorosis in Mexico. METHODS: Water fluoride levels in active wells were provided by the Water State Agency and divided into three zones: agriculture zone (Zone A), metallurgical zone (Zone B), and industrial zone (Zone C). Urinary fluoride levels were determined by potentiometric method using an ion-selective electrode. Health risk assessment was performed through Monte Carlo model analysis and hazard quotient was calculated. RESULTS: According to fluoride well concentration, all zones have high concentration especially Zone B (2.55 ± 0.98 mg/L). Urinary fluoride concentrations were highest in children in Zone B (1.42 ± 0.8 mg/L). The estimated median daily intake dose of fluoride was 0.084 mg/Kg-day for the children living in zone B. The highest mean HQ value was to Zone B (1.400 ± 0.980), followed by Zone C (0.626 ± 0.443). CONCLUSION: The levels of fluoride exposure registered are a potential risk to generate adverse health effects in children in the San Luis Potosi metropolitan area.
Subject(s)
Fluorides , Fluorosis, Dental/epidemiology , Groundwater , Child , Fluorides/analysis , Humans , Mexico/epidemiology , Risk Assessment , WaterABSTRACT
PURPOSE: Autophagy has lately emerged as an important biological process with implications in several hematological pathologies. Recently, a growing body of evidence supports a putative role of autophagy in chronic lymphocytic leukemia; however, no definitive clue has been established so far. To elucidate this issue, we have developed a pilot study to measure autophagic flux in peripheral blood mononuclear cells from chronic lymphocytic leukemia patients, and explored its correlation with classical clinical/analytical parameters. METHODS/PATIENTS: Thirty-three chronic lymphocytic leukemia patients participated in the study. Autophagic flux in peripheral blood mononuclear cells was determined by western blot measuring the levels of the proteins p62 and lipidated LC3. Moreover, p62 mRNA levels were analyzed by RT-qPCR. RESULTS: Lymphocytosis and the percentage of tumoral lymphocytes in chronic lymphocytic leukemia patients statistically correlate with a blocked autophagic flux. CONCLUSION: Alterations in autophagic flux could play an important role in the physiopathology of chronic lymphocytic leukemia.
Subject(s)
Autophagy , Biomarkers, Tumor/metabolism , Leukemia, Lymphocytic, Chronic, B-Cell/pathology , Leukocytes, Mononuclear/pathology , Lymphocytosis/pathology , Aged , Aged, 80 and over , Female , Follow-Up Studies , Humans , Leukemia, Lymphocytic, Chronic, B-Cell/metabolism , Leukocytes, Mononuclear/metabolism , Lymphocytosis/metabolism , Male , Middle Aged , Pilot Projects , PrognosisABSTRACT
TITLE: Mutacion del gen TK2 y miopatia de inicio tardio: descripcion del primer caso mexicano.
Subject(s)
Muscular Diseases/genetics , Mutation , Thymidine Kinase/genetics , Age of Onset , Female , Humans , Mexico , Young AdultABSTRACT
Case Report. A nine-year-old patient with a diagnosis of tuberous sclerosis (with no pathological record) that showed calcifications at the brain level. Besides, the case showed the Vogt triad (epilepsy, mental retardation, and sebaceous adenoma). The patient clinically showed a volume increase of hard consistency, without suppuration and no sessile that included the following teeth 73, 74, and 75. Cone beam computed tomography (CBCT) was obtained, and it displayed a delimited unilocular lesion. After surgical excision, the histopathological report was desmoplastic fibroma (DF). It was observed that the patient had an aggressive recurrence of DF at four months after surgery treatment. Due to these clinical findings, resective osseous surgery and curettage were carried out. It is uncommon to find these two pathologies together (DF and tuberous sclerosis). Since DF is a benign pathology but very invasive and destructive, it is necessary a constant follow-up examination due to a high recurrence frequency.
ABSTRACT
Melipona colimana Ayala is an endemic species inhabiting temperate forests of pine and oak of south of Jalisco in Mexico. During a year, it was recorded every 15 days foraging activity, environmental parameters and the development of colonies of M. colimana in its wild habitat. For five minutes every hour from 7:00 to 21:00, the bees that entered and left the hive and bringing pollen and resin were registered. Every hour the relative humidity, temperature, wind speed and light intensity was recorded and related to foraging activity. Additionally, the weight of the colonies recently transferred to wooden boxes, the number of brood combs, honey pots and pollen were registered. The time of beginning and ending of the foraging activity differs from the reports of stingless bees of tropical weather and the same happens with the pollen collection. The environmental parameters that affect other tropical stingless bees in the foraging activity also affect M. colimana in temperate climate. It was determined that the major activity season and the presence of more pollen pots in the colony is from November through February, for what it could be the best time of the year for the division and obtainance of new colonies, while the critical period of minor activity and pollen flow was during rainy season. These data may be useful for the future sustainable use of this species in temperate climate.(AU)
Melipona colimana Ayala é uma espécie endémica de clima temperado que habita nas florestas de pinho e de azinheira do sul de Jalisco, no México. Registrou-se durante um ano, todos os quinze dias, a atividade de forragem, os parâmetros ambientais e o desenvolvimento de colônias de M. colimana no seu habitat silvestre. Registrou-se durante cinco minutos, cada hora das 7:00 às 21:00, as abelhas que entraram e saíram da colmeia e as que traziam pólen e resinas. Registrou-se toda hora, a humidade relativa, temperatura, velocidade do vento e intensidade da luz e relacionaram-se à atividade de forragem. Além do mais, registrou-se o peso de colônias recém transferidas a gavetas de madeira e contabilizou-se o número de panais, potes de mel e pólen. A hora de início e de fim da atividade de forragem difere com os reportes das abelhas sem ferrão de clima tropical e o mesmo acontece com a recolecção de pólen. Os parâmetros ambientais que afetam outros meliponinos de clima tropical na forragem também afetam a M. colimana em clima temperado. Determinou-se que a temporada de maior atividade e a presença de mais potes de pólen na colônia é de Novembro a Fevereiro, razão pela qual pode ser a melhor temporada do ano para a divisão e obtenção de novas colônias, enquanto que o período crítico de menor atividade e fluxo de pólen foi durante a temporada de chuvas. Esses dados podem ser úteis para o futuro aproveitamento sustentável de esta espécie em clima temperado.(AU)
Subject(s)
Animals , Bees , Appetitive Behavior , Activity Cycles , Environmental Models , Population Dynamics , Temperate Zone , MexicoABSTRACT
Abstract Melipona colimana Ayala is an endemic species inhabiting temperate forests of pine and oak of south of Jalisco in Mexico. During a year, it was recorded every 15 days foraging activity, environmental parameters and the development of colonies of M. colimana in its wild habitat. For five minutes every hour from 7:00 to 21:00, the bees that entered and left the hive and bringing pollen and resin were registered. Every hour the relative humidity, temperature, wind speed and light intensity was recorded and related to foraging activity. Additionally, the weight of the colonies recently transferred to wooden boxes, the number of brood combs, honey pots and pollen were registered. The time of beginning and ending of the foraging activity differs from the reports of stingless bees of tropical weather and the same happens with the pollen collection. The environmental parameters that affect other tropical stingless bees in the foraging activity also affect M. colimana in temperate climate. It was determined that the major activity season and the presence of more pollen pots in the colony is from November through February, for what it could be the best time of the year for the division and obtainance of new colonies, while the critical period of minor activity and pollen flow was during rainy season. These data may be useful for the future sustainable use of this species in temperate climate.
Resumo Melipona colimana Ayala é uma espécie endémica de clima temperado que habita nas florestas de pinho e de azinheira do sul de Jalisco, no México. Registrou-se durante um ano, todos os quinze dias, a atividade de forragem, os parâmetros ambientais e o desenvolvimento de colônias de M. colimana no seu habitat silvestre. Registrou-se durante cinco minutos, cada hora das 7:00 às 21:00, as abelhas que entraram e saíram da colmeia e as que traziam pólen e resinas. Registrou-se toda hora, a humidade relativa, temperatura, velocidade do vento e intensidade da luz e relacionaram-se à atividade de forragem. Além do mais, registrou-se o peso de colônias recém transferidas a gavetas de madeira e contabilizou-se o número de panais, potes de mel e pólen. A hora de início e de fim da atividade de forragem difere com os reportes das abelhas sem ferrão de clima tropical e o mesmo acontece com a recolecção de pólen. Os parâmetros ambientais que afetam outros meliponinos de clima tropical na forragem também afetam a M. colimana em clima temperado. Determinou-se que a temporada de maior atividade e a presença de mais potes de pólen na colônia é de Novembro a Fevereiro, razão pela qual pode ser a melhor temporada do ano para a divisão e obtenção de novas colônias, enquanto que o período crítico de menor atividade e fluxo de pólen foi durante a temporada de chuvas. Esses dados podem ser úteis para o futuro aproveitamento sustentável de esta espécie em clima temperado.
Subject(s)
Animals , Bees/physiology , Environment , Nesting Behavior , Seasons , Feeding Behavior , MexicoABSTRACT
BACKGROUND/AIM: First-line bevacizumab-based therapies have been shown to improve clinical outcomes in patients with non-squamous non-small-cell lung cancer (NSCLC). We aimed to descriptively analyse patients with non-squamous NSCLC who received a long-term period of maintenance bevacizumab. PATIENTS AND METHODS: This retrospective study included 104 patients who had already reached a progression-free survival (PFS) of at least 9 months. RESULTS: Median overall survival and PFS were 30.7 and 15.1 months, respectively. The overall response rate was 83 %. Weight loss ≤5 %, ECOG PS = 0, or low number of metastatic sites seem to be predictive factors of good evolution. The incidence of bevacizumab-related adverse events appeared to be similar as the previous studies. CONCLUSION: Our findings show that there is a long-term survivor group whom the administration of bevacizumab resulted in a relevant prolongation of response without new safety signals. Due to the population heterogeneity, it was not possible to identify the standardised predictive factors.
Subject(s)
Adenocarcinoma/mortality , Angiogenesis Inhibitors/therapeutic use , Bevacizumab/therapeutic use , Carcinoma, Large Cell/mortality , Carcinoma, Non-Small-Cell Lung/mortality , Lung Neoplasms/mortality , Adenocarcinoma/drug therapy , Adenocarcinoma/pathology , Aged , Carcinoma, Large Cell/drug therapy , Carcinoma, Large Cell/pathology , Carcinoma, Non-Small-Cell Lung/drug therapy , Carcinoma, Non-Small-Cell Lung/pathology , Female , Follow-Up Studies , Humans , Lung Neoplasms/drug therapy , Lung Neoplasms/pathology , Male , Middle Aged , Neoplasm Invasiveness , Neoplasm Metastasis , Neoplasm Staging , Prognosis , Retrospective Studies , Survival Rate , SurvivorsABSTRACT
Melipona colimana Ayala is an endemic species inhabiting temperate forests of pine and oak of south of Jalisco in Mexico. During a year, it was recorded every 15 days foraging activity, environmental parameters and the development of colonies of M. colimana in its wild habitat. For five minutes every hour from 7:00 to 21:00, the bees that entered and left the hive and bringing pollen and resin were registered. Every hour the relative humidity, temperature, wind speed and light intensity was recorded and related to foraging activity. Additionally, the weight of the colonies recently transferred to wooden boxes, the number of brood combs, honey pots and pollen were registered. The time of beginning and ending of the foraging activity differs from the reports of stingless bees of tropical weather and the same happens with the pollen collection. The environmental parameters that affect other tropical stingless bees in the foraging activity also affect M. colimana in temperate climate. It was determined that the major activity season and the presence of more pollen pots in the colony is from November through February, for what it could be the best time of the year for the division and obtainance of new colonies, while the critical period of minor activity and pollen flow was during rainy season. These data may be useful for the future sustainable use of this species in temperate climate.
Subject(s)
Bees/physiology , Environment , Nesting Behavior , Animals , Feeding Behavior , Mexico , SeasonsABSTRACT
Photoreflectance-difference (PR/PRD) and reflectance-difference (RD) spectroscopies employ synchronic detection usually with lock-in amplifiers operating at moderate (200-1000 Hz) and high (50-100 KHz) modulation frequencies, respectively. Here, we report a measurement system for these spectroscopies based on a multichannel CCD spectrometer without a lock-in amplifier. In the proposed scheme, a typical PRD or RD spectrum consists of numerical subtractions between a thousand CCD captures recorded, while a photoelastic modulator is either operating or inhibited. This is advantageous and fits the slow response of CCD detectors to high modulation frequencies. The resulting spectra are processed with Savitzky-Golay filtering and compared well with those measured with conventional scanning systems based on lock-in amplifiers.
ABSTRACT
In a 1-year survey at a university hospital we found that 20·6% (81/392) of patients with antibiotic associated diarrohea where positive for C. difficile. The most common PCR ribotypes were 012 (14·8%), 027 (12·3%), 046 (12·3%) and 014/020 (9·9). The incidence rate was 2·6 cases of C. difficile infection for every 1000 outpatients.
Subject(s)
Clostridioides difficile/genetics , Cross Infection/epidemiology , Enterocolitis, Pseudomembranous/epidemiology , Hospitals, University , Tertiary Care Centers , Anti-Bacterial Agents/pharmacology , Anti-Bacterial Agents/therapeutic use , Chile/epidemiology , Clostridioides difficile/drug effects , Clostridioides difficile/isolation & purification , Cross Infection/drug therapy , Cross Infection/microbiology , Enterocolitis, Pseudomembranous/drug therapy , Enterocolitis, Pseudomembranous/microbiology , Humans , Incidence , Middle Aged , Polymerase Chain Reaction , RibotypingABSTRACT
We report on the experimental observation of spatially modulated kinks in a shallow one-dimensional fluidized granular layer subjected to a periodic air flow. We show the appearance of these solutions as the layer undergoes a parametric instability. Due to the inherent fluctuations of the granular layer, the kink profile exhibits an effective wavelength, a precursor, which modulates spatially the homogeneous states and drastically modifies the kink dynamics. We characterize the average and fluctuating properties of this solution. Finally, we show that the temporal evolution of these kinks is dominated by a hopping dynamics, related directly to the underlying spatial structure.
ABSTRACT
UNLABELLED: Fibrodysplasia ossificans gressiva (FOP) syndrome is a very rare connective tissue disease characterized clinically by the progressive ossification of the soft tissues, usually with hallux malformation. MATERIAL AND METHODS: Three patients diagnosed with FOP during 2006 were clinically, radiographically and tomographically assessed. RESULTS: Three female patients ages 4, 6 and 12 years old with hallux deformity and indurated tumors of the trunk, neck and shoulders. CONCLUSION: FOP is a rare autosomal dominant genetic disease that manifests itself with ossification of the soft tissues, which progressively limits joint and trunk mobility.
Subject(s)
Myositis Ossificans , Child , Child, Preschool , Female , Humans , Myositis Ossificans/diagnosis , SyndromeABSTRACT
Contexto: El desarrollo de la Angiotomografía (AngioTC) pulmonar ha mejorado significativamente la detecciónde embolismos pulmonares, por lo cual podría transformarse en la prueba diagnóstica de elección.Objetivo: Determinar la frecuencia de casos positivos para TEP identificados mediante AngioTC y la relación entrelos hallazgos radiológicos y el grado de sospecha clínica.Diseño: Estudio transversal.Lugar y sujetos: Pacientes que acudieron consecutivamente al Servicio de Imagen del Hospital de ClínicasPichincha y al instituto Radiólogos Asociados, de la ciudad de Quito, para someterse a AngioTC por un diagnósticosospechoso de TEP.Mediciones principales: Probabilidad clínica de embolismo pulmonar valorada mediante la Escala de Wells, Estudios de AngioTC realizados con Tomógrafo Phillips brillante de 16 detectores. Los criterios diagnósticos incluyeron identificación de oclusión arterial, defectos de llenado parcial y defectos dellenado intraluminales periféricos.Resultados: De un total de 76 pacientes investigados se encontraron 21 casos positivos (27.6 por ciento) para TEP, siendola mayoría del género femenino (57.1 por ciento). La edad de presentación estuvo entre 61-80 años (47.6 por ciento). Los hallazgos tomográficos evidenciaron 7 casos de embolismo pulmonar masivo (33.3 por ciento), 4 (19.0 por ciento) en arterias pulmonares principales, 4 (19.0 por ciento) tanto en arterias pulmonares principales y segmentarias; sólo existió un caso en arterias subsegmentarias. En el 61.9 por ciento de las veces la TEP estuvo asociada con infarto pulmonar. En los casos con probabilidad clínica alta, donde la AngioTC tuvo una sensibilidad del 38 por ciento, VPP de 80 por ciento y LR + de 10.5; para la probabilidad clínica intermedia se observó variación en estos indicadores (61.9 por ciento, 38.2 por ciento y 1.62, respectivamente)...
Subject(s)
Pulmonary Embolism/diagnosis , TomographyABSTRACT
INTRODUCTION: Chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) is a chronic, but potentially treatable, acquired autoimmune neuropathy. A review of the literature shows that few studies have been conducted on its epidemiology, presenting symptoms and long-term functional prognosis. AIM: To describe the clinical and neurophysiological forms of patients with CIDP at the outset and their follow-up at one year. PATIENTS AND METHODS: We conducted a descriptive, retrospective study of patients who were hospitalised in our unit between 1995 and 2005. The cases were defined in accordance with Inflammatory Neuropathy Cause and Treatment (INCAT) group criteria. Data gathered included demographic characteristics, forms of clinical presentation, neurophysiological findings, cerebrospinal fluid and functional prognosis at one year. A statistical descriptive analysis was performed. RESULTS: The sample consisted of 26 patients--12 males (46.15%) and 14 females (53.84%)--between 15 and 71 years of age (40.17 +/- 15.7 years). CIDP was associated with other autoimmune diseases in 20.8% of the patients. The predominant features at the outset of the disease were paresis and distal symmetrical paresthesias in the four limbs, high protein levels in cerebrospinal fluid and demyelination with axonal degeneration. Prednisone was administered in 43% of the cases. At one year, five patients remained asymptomatic (22.72%), there was a partial improvement in 13 (59.09%) and no improvement was seen in four cases (18.18%). CONCLUSIONS: The most frequent initial form of clinical presentation of CIDP in our population is quadriparesis and distal symmetrical paresthesias, high protein levels in cerebrospinal fluid and demyelination with axonal degeneration, which are related to a good functional prognosis at one year.
Subject(s)
Polyradiculoneuropathy, Chronic Inflammatory Demyelinating/diagnosis , Adolescent , Adult , Aged , Cross-Sectional Studies , Female , Humans , Male , Mexico , Middle Aged , Retrospective StudiesABSTRACT
INTRODUCTION: Brachial diplegia refers to an atypical clinical variant of amyotrophic lateral sclerosis (ALS), which is defined as a lower motor neuron disease in the upper limbs, with no significant functional complications in other regions. CASE REPORT: A 65-year-old female who presented a clinical picture of brachial diplegia that slowly progressed over a period of 72 months. Neurophysiology studies revealed a chronic denervation process. Throughout a follow-up lasting one year the clinical course remained stable. CONCLUSIONS: Brachial diplegia in females is a rare form of presentation of ALS and they probably have a higher survival rate than males.